3,5-二甲基-2-噻吩甲醛 | 85895-83-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 中文名称: 3,5-二甲基-2-噻吩甲醛
• 英文名称: 3,5-dimethylthiophene-2-carbaldehyde
• 英文别名: 3,5-dimethyl-2-thiophenecarboxaldehyde
• CAS: 85895-83-6
• 化学式: C₇H₈OS
• 分子量: 140.206
• InChiKey: NQWNJWZLWMCDOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  45.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  3,5-二甲基-2-噻吩甲醛 在 对甲苯磺酸 、 三乙胺 作用下， 以 二甲基亚砜 为溶剂， 反应 24.17h， 生成 diethyl <3-methyl-5-(4-hydroxybenzyl)-2-thienyl>-methyl-phosphonate
  参考文献：
  名称：

  酸性介质中噻吩基膦酰基甲醇的反应性：芳基-和烷氧基-噻吩基甲烷衍生物的合成

  摘要：

  摘要 2-噻吩基-膦酰基甲醇在酸性介质中与醇类和芳香族衍生物根据反应温度的不同得到两类新化合物。

  DOI：

  10.1080/00397919208019272
• 作为产物：
  描述：

  3-甲基噻吩 在 正丁基锂 、 乙醚 作用下， 生成 3,5-二甲基-2-噻吩甲醛
  参考文献：
  名称：

  SUBSTITUTED THENOIC ACIDS

  摘要：

  DOI：

  10.1021/jo01366a013

文献信息

• Synthesis and photochromic properties of tetrakis(3,5-dimethyl-2-thienyl)- and tetrakis(2,5-dimethyl-3-thienyl)ethylenes
  作者：L. I. Belen'kii、G. P. Gromova、A. V. Kolotaev、B. V. Nabatov、M. M. Krayushkin

  DOI：10.1007/s11172-005-0382-5

  日期：2005.5

  Tetrakis(3,5-dimethyl-2-thienyl)ethylene and tetrakis(2,5-dimethyl-3-thienyl)ethylene were obtained from the corresponding dithienyl ketones by the McMurry reaction. The photochromic properties of the compounds obtained were studied.

  四(3,5-二甲基-2-噻吩基)乙烯和四(2,5-二甲基-3-噻吩基)乙烯是通过McMurry反应从相应的二噻吩酮获得的。对所获得化合物的光致变色性质进行了研究。
• 1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：US20170044187A1

  公开（公告）日：2017-02-16

  Provided are 1-(3-aminopropyl) substituted cyclic amine compounds as represented by formula (I), pharmaceutically acceptable salts, enantiomers, diastereoisomers, racemates and mixtures thereof, and a method of synthesizing said 1-(3-aminopropyl) substituted cyclic amine compounds by using aromatic heterocyclic formaldehyde as raw material. Said compounds can be used as CCR 5 antagonist for the treatment of HIV infection.

  提供了以公式(I)表示的1-(3-氨基丙基)取代的环胺化合物，包括药用可接受的盐、对映体、非对映异构体、混合物和拉克酸盐，以及使用芳香杂环甲醛作为原料合成所述的1-(3-氨基丙基)取代的环胺化合物的方法。这些化合物可用作CCR 5受体拮抗剂，用于治疗HIV感染。
• Indolinone combinatorial libraries and related products and methods for the treatment of disease
  申请人：Tang Cho Peng

  公开号：US20050197382A1

  公开（公告）日：2005-09-08

  The present invention relates to organic molecules capable of modulating, regulating and/or inhibiting protein kinase signal transduction. Such compounds are useful for the treatment of diseases related to unregulated protein kinase signal transduction, including cell proliferative diseases such as cancer, atherosclerosis, arthritis and restenosis and metabolic diseases such as diabetes. The present invention features indolinone compounds that potently inhibit protein kinases and related products and methods. Inhibitors specific to the FLK protein kinase can be obtained by adding chemical substituents to the 3-[(indole-3-yl)methylene]-2-indolinone, in particular at the 1′ position of the indole ring. Indolinone compounds that specifically inhibit the FLK and platelet derived growth factor protein kinases can harbor a tetrahydroindole or cyclopentano-b-pyrrol moiety. Indolinone compounds that are modified with substituents, particularly at the 5 position of the oxindole ring, can effectively activate protein kinases. This invention also features novel hydrosoluble indolinone compounds that are tyrosine kinase inhibitors and related products and methods.

  本发明涉及有机分子，能够调节、调控和/或抑制蛋白激酶信号转导。这些化合物对于治疗与不受调节的蛋白激酶信号转导相关的疾病非常有用，包括细胞增殖性疾病，如癌症、动脉粥样硬化、关节炎、再狭窄和代谢性疾病，如糖尿病。本发明涉及具有强效抑制蛋白激酶和相关产品以及方法的吲哚酮化合物。特定于FLK蛋白激酶的抑制剂可以通过在吲哚环的1'位置添加化学取代基来获得3-[(吲哚-3-基)亚甲基]-2-吲哚酮。特异性抑制FLK和血小板衍生生长因子蛋白激酶的吲哚酮化合物可以具有四氢吲哚或环戊烯基-β-吡咯基。在氧吲哚环的5位取代基的修饰下，吲哚酮化合物可以有效激活蛋白激酶。本发明还涉及新型水溶性吲哚酮化合物，它们是酪氨酸激酶抑制剂和相关产品和方法。
• PGD2 receptor antagonists for the treatment of inflammatory diseases
  申请人：Ghosh Shomir

  公开号：US20090181966A1

  公开（公告）日：2009-07-16

  Disclosed herein are compounds represented by Structural Formula (I) and (I-A): Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply “CRTH2” for the treatment of inflammatory disorders. The variables in Structural Formula (I) and (I-A) are defined herein.

  本文公开了由结构式（I）和（I-A）表示的化合物： 同时，还公开了使用这些化合物抑制G蛋白偶联受体，称为趋化因子受体同源分子表达在Th2上，或简称为“CRTH2”治疗炎症性疾病的方法。结构式（I）和（I-A）中的变量在本文中有定义。
• E/Z isomerization of a thermally bistable photochromic dithienylethene
  作者：Michinori Takeshita、Takuya Hirowatari、Atsushi Takedomi

  DOI：10.1016/j.tetlet.2016.06.122

  日期：2016.8

  A simple photochromic dithienylethene compound undergoes thermally irreversible E–Z isomerization, representing the first example of a thermally bistable dithienylethene switching between E and Z isomers even at high temperatures.

  一种简单的光致变色二噻吩乙烯化合物经历了热不可逆的E - Z异构化反应，代表了即使在高温下，热双稳态二噻吩乙烯也可在E和Z异构体之间转换的第一个例子。