3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)propan-1-ol | 1446492-22-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)propan-1-ol
• CAS: 1446492-22-3
• 化学式: C₁₅H₂₀ClNO₂
• 分子量: 281.782
• InChiKey: UZGCUUWGFQJXGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)propan-1-ol 在 水 、 三苯基膦 、 N,N'-羰基二咪唑 、 sodium hydroxide 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 40.0h， 生成 methyl 1-[2-[3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)propoxy]-4-fluorobenzoyl]-4,4-dimethylpyrrolidine-3-carboxylate
  参考文献：
  名称：

  Design, synthesis and structure–activity relationships of zwitterionic spirocyclic compounds as potent CCR1 antagonists

  摘要：

  A series of zwitterionic spirocyclic compounds were synthesised. In vitro data revealed that these compounds were potent CCR1 antagonists. In particular, 2, 4, 11 and 20 inhibited CCR1 mediated chemotaxis of THP-1 cells in a functional assay. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.05.087
• 作为产物：
  描述：

  5-氯螺[3H-苯并呋喃-2,4'-哌啶] 、 3-溴-1-丙醇 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 48.0h， 以79%的产率得到3-(5-chlorospiro[3H-1-benzofuran-2,4'-piperidine]-1'-yl)propan-1-ol
  参考文献：
  名称：

  Design, synthesis and structure–activity relationships of zwitterionic spirocyclic compounds as potent CCR1 antagonists

  摘要：

  A series of zwitterionic spirocyclic compounds were synthesised. In vitro data revealed that these compounds were potent CCR1 antagonists. In particular, 2, 4, 11 and 20 inhibited CCR1 mediated chemotaxis of THP-1 cells in a functional assay. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.05.087

文献信息

• Design, synthesis and structure–activity relationships of zwitterionic spirocyclic compounds as potent CCR1 antagonists
  作者：Nafizal Hossain、Svetlana Ivanova、Åsa Sjöholm Timén、Jonas Bergare、Tesfaledet Mussie、Lena Bergström

  DOI：10.1016/j.bmcl.2013.05.087

  日期：2013.7

  A series of zwitterionic spirocyclic compounds were synthesised. In vitro data revealed that these compounds were potent CCR1 antagonists. In particular, 2, 4, 11 and 20 inhibited CCR1 mediated chemotaxis of THP-1 cells in a functional assay. (C) 2013 Elsevier Ltd. All rights reserved.