butyl-(2-chloro-ethyl)-methyl-amine; hydrochloride | 115571-72-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: butyl-(2-chloro-ethyl)-methyl-amine; hydrochloride
• 英文别名: Butyl-(2-chlor-aethyl)-methyl-amin; Hydrochlorid；Butyl-(2-chlor-aethyl)-methyl-ammonium-chlorid；2-(N-Methyl-N-butylamino)ethyl chloride hydrochloride；N-(2-chloroethyl)-N-methylbutan-1-amine;hydrochloride
• CAS: 115571-72-7
• 化学式: C₇H₁₆ClN*ClH
• 分子量: 186.125
• InChiKey: OPNUBWBPOZDXDJ-UHFFFAOYSA-N

物化性质

• 熔点：
  119-120 °C

计算性质

• 辛醇/水分配系数(LogP)：
  2.38
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2921199090

反应信息

• 作为反应物：
  描述：

  butyl-(2-chloro-ethyl)-methyl-amine; hydrochloride 生成 1,1-Bis-[2-(n-butyl-methyl-amino)-ethyl]-hydrazin
  参考文献：
  名称：

  氨基烷基肼的合成及其生物学性质。1-（2-二乙基氨基乙基）-2-（1-苯基-2-丙基））嗪的独特氮-氮键合。

  摘要：

  DOI：

  10.1021/jm00334a021

文献信息

• Analogs of Indole-3-Carbinol and Their Use as Agents Against Infection
  申请人：Jong Ling

  公开号：US20100069355A1

  公开（公告）日：2010-03-18

  Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2′-diindolylmethane, 2′,3-diindolylmethane, and 3,3′-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.

  提供了作为抗菌剂有用的化合物。这些化合物是吲哚-3-甲醇的类似物，具有从二氢吲哚并[2,3-b]咔唑，2,2′-二吲哚甲烷，2′,3-二吲哚甲烷和3,3′-二吲哚甲烷中选择的骨架。这些化合物对哺乳动物的细菌感染的治疗和预防治疗有用。提供了合成这些化合物的方法，以及含有这些化合物的药物组合物。
• Novel 2-aryl-naphtho[1,2-d]oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities
  作者：Atul Kumar、Pervez Ahmad、Ram Awatar Maurya、A.B. Singh、Arvind K. Srivastava

  DOI：10.1016/j.ejmech.2008.03.009

  日期：2009.1

  A series of 2-aryl-naphtho[1,2-d]oxazole derivatives have been synthesized and evaluated for PTP-1B inhibitory activity. The compounds have been screened in vivo for antidiabetic activity under sucrose loaded model (SLM), sucrose-challenged streptozotocin-induced diabetic rat model (STZ-S) and db/db mice model. Compounds 8 and 12 have shown promising PTP-1B inhibitory activity, significant antidiabetic activity, moderate lipid and triglyceride lowering activity. (C) 2008 Elsevier Masson SAS. All rights reserved.
• Bis basic-substituted polycyclic aromatic compounds. New class of antiviral agents. 2. Tilorone and related bis-basic ethers of fluorenone, fluorenol, and fluorene
  作者：Edwin R. Andrews、Robert W. Fleming、J. Martin Grisar、James C. Kihm、David L. Wenstrup、Gerald D. Mayer

  DOI：10.1021/jm00254a020

  日期：1974.8
• ANALOGS OF INDOLE-3-CARBINOL AND THEIR USE AS AGENTS AGAINST INFECTION
  申请人：SRI International

  公开号：EP2326327A2

  公开（公告）日：2011-06-01
• US8278341B2
  申请人：——

  公开号：US8278341B2

  公开（公告）日：2012-10-02