1-Methyl-1-phenyl-2-<3-nitro-phenyl>-aethylen | 92552-84-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-Methyl-1-phenyl-2-<3-nitro-phenyl>-aethylen
• 英文别名: 1-Methyl-1-phenyl-2-(3-nitro-phenyl)-aethylen；1-(3-Nitrophenyl)-2-phenyl-1-propene；1-nitro-3-(2-phenylprop-1-enyl)benzene
• CAS: 92552-84-6
• 化学式: C₁₅H₁₃NO₂
• 分子量: 239.274
• InChiKey: FRFAOBRKNCPVTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Methyl-1-phenyl-2-<3-nitro-phenyl>-aethylen 在 盐酸 、 tin 作用下， 生成 1-Methyl-1-phenyl-2-(3-amino-phenyl)-aethylen
  参考文献：
  名称：

  Dombrovskii,A.V. et al., Journal of general chemistry of the USSR, 1962, vol. 32, p. 592 - 596

  摘要：

  DOI：
• 作为产物：
  描述：

  间硝基苯胺 、 2-苯基-1-丙烯 生成 1-Methyl-1-phenyl-2-<3-nitro-phenyl>-aethylen
  参考文献：
  名称：

  Dombrovskii,A.V. et al., Journal of general chemistry of the USSR, 1962, vol. 32, p. 592 - 596

  摘要：

  DOI：

文献信息

• Arylalkyl-amines having anticonvulsant and neuroprotective properties
  申请人：Astra AB

  公开号：US05605916A1

  公开（公告）日：1997-02-25

  There is provided a method of treatment of neurological disorders, such as epilepsy, stroke and cerebral ischaemia, which comprises the administration of a compound of Formula I: ##STR1## wherein, Ar.sub.1 and Ar.sub.2, which may be the same or different, independently represent phenyl or phenyl substituted by one or more of amino, nitro, halogen, hydroxy, C1 to 6 alkoxy, C1 to 6 alkyl or cyano; R.sub.1 represents hydrogen, C1 to 6 alkyl, C1 to 6 alkoxycarbonyl; R.sub.2 represents hydrogen or COCH.sub.2 NH.sub.2 ; R.sub.3 represents hydrogen or C1 to 6 alkyl; in addition, when R.sub.2 represents hydrogen either one or both of Ar.sub.1 and Ar.sub.2 may also represent 2-, 3- or 4-pyridinyl and R.sub.1 may also represent trihalomethyl; or a pharmaceutically acceptable salt thereof. Some of the compounds of formula I are novel, and these are also provided, together with pharmaceutical compositions containing the novel compounds.

  提供了一种治疗神经系统疾病（如癫痫、中风和脑缺血）的方法，其中包括给予化合物I的治疗：##STR1##其中，Ar.sub.1和Ar.sub.2可以相同或不同，独立地表示苯基或被氨基、硝基、卤素、羟基、C1到6烷氧基、C1到6烷基或氰基等取代的苯基；R.sub.1表示氢、C1到6烷基、C1到6烷氧基羰基；R.sub.2表示氢或COCH.sub.2 NH.sub.2；R.sub.3表示氢或C1到6烷基；此外，当R.sub.2表示氢时，Ar.sub.1和Ar.sub.2中的任意一个或两个也可以表示2-、3-或4-吡啶基，R.sub.1也可以表示三卤甲基；或其药学上可接受的盐。其中，化合物I中的一些是新型化合物，同时也提供这些新型化合物的制药组合物。
• Arylalkyl-amines and -amides having anticonvulsant and neuroprotective
  申请人：Fisons Corporation

  公开号：US05430044A1

  公开（公告）日：1995-07-04

  There is provided a method of treatment of neurological disorders, such as epilepsy, stroke and cerebral ischaemia, which comprises the administration of a compound of Formula I: ##STR1## wherein, Ar.sub.1 and Ar.sub.2, which may be the same or different, independently represent phenyl or phenyl substituted by one or more of amino, nitro, halogen, hydroxy, C1 to 6 alkoxy, C1 to 6 alkyl or cyano; R.sub.1 represents hydrogen, C1 to 6 alkyl, C1 to 6 alkoxycarbonyl; R.sub.2 represents hydrogen or COCH.sub.2 NH.sub.2 ; R.sub.3 represents hydrogen or C1 to 6 alkyl; in addition, when R.sub.2 represents hydrogen either one or both of Ar.sub.1 and Ar.sub.2 may also represent 2-, 3- or 4-pyridinyl and R.sub.1 may also represent trihalomethyl; or a pharmaceutically acceptable salt thereof. Some of the compounds of formula I are novel, and these are also provided, together with pharmaceutical compositions containing the novel compounds.

  提供了一种治疗神经系统疾病，如癫痫、中风和脑缺血的方法，该方法包括给予式I的化合物：##STR1## 其中，Ar.sub.1和Ar.sub.2可以相同或不同，独立地代表苯基或被一个或多个氨基，硝基，卤素，羟基，C1到6烷氧基，C1到6烷基或氰基取代的苯基；R.sub.1代表氢，C1到6烷基，C1到6烷氧羰基；R.sub.2代表氢或COCH.sub.2 NH.sub.2；R.sub.3代表氢或C1到6烷基；此外，当R.sub.2代表氢时，Ar.sub.1和Ar.sub.2中的任意一个或两个也可以代表2-，3-或4-吡啶基，而R.sub.1也可以代表三卤甲基；或其药学上可接受的盐。式I的某些化合物是新颖的，同时提供这些化合物以及含有新颖化合物的制药组合物。