cis-1,1-Difluoro-2,3-diphenylcyclopropane | 114309-61-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: cis-1,1-Difluoro-2,3-diphenylcyclopropane
• 英文别名: 1,1-Difluoro-2alpha,3alpha-diphenylcyclopropane；[(1S,3R)-2,2-difluoro-3-phenylcyclopropyl]benzene
• CAS: 114309-61-4
• 化学式: C₁₅H₁₂F₂
• 分子量: 230.257
• InChiKey: RFAPWLIILBCXGW-OKILXGFUSA-N

物化性质

• 沸点：
  294.5±40.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  顺式-二苯乙烯 、 Bis(trifluormethyl)cadmium 以 氯仿 为溶剂， 生成 cis-1,1-Difluoro-2,3-diphenylcyclopropane
  参考文献：
  名称：

  Donor-free bis(trifluoromethyl) cadmium, (CF3)2Cd: a readily available low-temperature difluorocarbene source

  摘要：

  Donor-free bis(trifluoromethyl)cadmium, (CF3)(2)Cd, has been obtained at -40 degrees C from diethylcadmium and CF3I in a quantitative yield. The Raman spectrum of (CF3)(2)Cd is reported. In the presence of non-coordinating solvents the highly reactive compound eliminates CF2 even below -5 degrees C. Its feasibility as a low temperature difluorocarbene source has been demonstrated by difluorocyclo-propenation reactions with some alkenes and alkynes as well as by insertion into metal-chlorine bonds. The NMR spectra of some CF2Cl- and CF3-containing arsanes are reported.

  DOI：

  10.1016/0022-328x(95)05848-j

文献信息

• [EN] COMPOUNDS<br/>[FR] COMPOSÉS
  申请人：UNIV WARWICK

  公开号：WO2017216507A1

  公开（公告）日：2017-12-21

  The invention relates to difluorocyclopropane compounds, methods for their manufacture, and their uses for example as medicaments. According to one aspect, there is provided a compound of general formula (I): wherein X and Y are phenyl groups, one of which is substituted by an ethoxyamine basic side chain; R1 and R2 are independently selected from H or a C1-C6 alkyl group; and wherein one or each of X and Y, and the or each C1-C6 alkyl group, are optionally substituted or further substituted by one or more alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radicals of 1 to 20 carbon atoms, and/or by one or more fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyloraminodialkyl radicals.

  该发明涉及二氟环丙烷化合物，其制备方法以及它们作为药物的用途。根据一个方面，提供了一种通式(I)的化合物：其中X和Y是苯基，其中一个被乙氧胺基侧链取代；R1和R2分别选自H或C1-C6烷基；其中X和Y中的一个或每一个，以及每个C1-C6烷基，可以选择性地被一个或多个碳原子数为1到20的烷基、卤代烷基、烷氧基、卤代烷氧基、烯基、炔基或烷基氨基基团取代或进一步取代，和/或被一个或多个氟、氯、溴、碘、羟基、氧烷基、氨基、氨基烷基或氨基二烷基基团取代。
• JI, GUO-ZHEN;CHEN, GUO-FEI;WU, ZONG-MEI;JIANG, XI-KUI, ACTA CHIM. SIN., 45,(1987) N 9, 904-909
  作者：JI, GUO-ZHEN、CHEN, GUO-FEI、WU, ZONG-MEI、JIANG, XI-KUI

  DOI：——

  日期：——
• Donor-free bis(trifluoromethyl) cadmium, (CF3)2Cd: a readily available low-temperature difluorocarbene source
  作者：R. Eujen、B. Hoge

  DOI：10.1016/0022-328x(95)05848-j

  日期：1995.11

  Donor-free bis(trifluoromethyl)cadmium, (CF3)(2)Cd, has been obtained at -40 degrees C from diethylcadmium and CF3I in a quantitative yield. The Raman spectrum of (CF3)(2)Cd is reported. In the presence of non-coordinating solvents the highly reactive compound eliminates CF2 even below -5 degrees C. Its feasibility as a low temperature difluorocarbene source has been demonstrated by difluorocyclo-propenation reactions with some alkenes and alkynes as well as by insertion into metal-chlorine bonds. The NMR spectra of some CF2Cl- and CF3-containing arsanes are reported.