N-(1-benzylpiperidin-4-yl)-3-chloro-4-(1-(4-methoxybenzyl)piperidin-4-yloxy)benzamide | 1037490-26-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(1-benzylpiperidin-4-yl)-3-chloro-4-(1-(4-methoxybenzyl)piperidin-4-yloxy)benzamide
• 英文别名: N-(1-benzylpiperidin-4-yl)-3-chloro-4-(1-(4-methoxybenzyl)-piperidin-4-yloxy)-benzamide；N-(1-benzylpiperidin-4-yl)-3-chloro-4-[1-[(4-methoxyphenyl)methyl]piperidin-4-yl]oxybenzamide
• CAS: 1037490-26-8
• 化学式: C₃₂H₃₈ClN₃O₃
• 分子量: 548.125
• InChiKey: OPZIJNBWFXUVDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  54
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-氨基-1-苄基哌啶 、 3-chloro-4-(1-(4-methoxybenzyl)piperidin-4-yloxy)benzoic acid 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以18%的产率得到N-(1-benzylpiperidin-4-yl)-3-chloro-4-(1-(4-methoxybenzyl)piperidin-4-yloxy)benzamide
  参考文献：
  名称：

  WO2008/83124

  摘要：

  公开号：

文献信息

• N-Substituted-Heterocycloalkyloxybenzamide Compounds and Methods of Use
  申请人：Singh Rajinder

  公开号：US20110306767A1

  公开（公告）日：2011-12-15

  The present invention provides N-substituted-heterocycloalkyloxybenzamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment of the invention is a compound having the structure in which R 1 , R 2 , R 3 , R 4 , T, n, w and x are as described herein. In certain embodiments of the invention, a compound of the present invention activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

  本发明提供了N-取代-杂环烷氧基苯甲酰胺化合物，以及其制备的药物组合物和使用方法。本发明的一个实施例是一种具有以下结构的化合物，在该结构中，R1、R2、R3、R4、T、n、w和x如本文所述。在本发明的某些实施例中，本发明的化合物可以激活AMPK通路，并可用于治疗代谢相关的疾病和病状。
• N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US08012955B2

  公开（公告）日：2011-09-06

  The present invention provides N-substituted-heterocycloalkyloxybenzamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment of the invention is a compound having the structure in which R1, R2, R3, R4, T, n, w and x are as described herein. In certain embodiments of the invention, a compound of the present invention activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

  本发明提供了N-取代-杂环烷基氧基苯甲酰胺化合物，以及其药物组合物和使用方法。本发明的一种实施方式是具有以下结构的化合物，其中R1、R2、R3、R4、T、n、w和x如本文所述。在本发明的某些实施方式中，本发明的化合物可以激活AMPK途径，并可用于治疗与代谢相关的疾病和病况。
• Carboxamide, Sulfonamide and Amine Compounds and Methods for Using Them
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US20140378429A1

  公开（公告）日：2014-12-25

  The disclosure relates particularly to certain carboxamide, sulfonamide and amine compounds and pharmaceutical compositions thereof, and to methods of treating and ameliorating disorders and conditions related to the adiponectin pathway, sphingolipid metabolism, oxidative stress, mitochondrial dysfunction, free radical damage and metabolic inefficiency, among others. In certain embodiments, the compounds have the structures (I-1), (2-I) and (3-I) (The chemical formulas should be inserted here) in which the variables are as described herein.

  本公开涉及特定的羧酰胺、磺酰胺和胺化合物及其制药组合物，以及治疗和改善与脂联素途径、鞘脂代谢、氧化应激、线粒体功能障碍、自由基损伤和代谢效率等相关的疾病和病症的方法。在某些实施例中，化合物具有结构（I-1）、（2-I）和（3-I）（化学式应在此处插入），其中变量如本文所述。
• N-SUBSTITUTED-HETEROCYCLOALKYLOXYBENZAMIDE COMPOUNDS AND METHODS OF USE
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：EP2079694A1

  公开（公告）日：2009-07-22
• Methods for Using Carboxamide, Sulfonamide and Amine Compounds
  申请人：Payan Donald

  公开号：US20110245222A1

  公开（公告）日：2011-10-06

  Disclosed are uses of carboxamide, sulfonamide and amine compounds for the treatment and amelioration of disorders and conditions related to oxidative stress, mitochondrial dysfunction, free radical damage and metabolic inefficiency, among others. Also described are methods for increasing exercise endurance, exercise efficiency and aerobic workload using the compounds described herein.