2,3-diformyl-1,4-naphthoquinol | 73861-61-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2,3-diformyl-1,4-naphthoquinol
• 英文别名: 1,4-Dihydroxynaphthalene-2,3-dicarbaldehyde
• CAS: 73861-61-7
• 化学式: C₁₂H₈O₄
• 分子量: 216.193
• InChiKey: LOUSIFBWSKPXFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,3-bis-piperidin-1-ylmethyl-naphthalene-1,4-diol 在 chromium(VI) oxide 、 溶剂黄146 作用下， 反应 0.17h， 以16%的产率得到2,3-diformyl-1,4-naphthoquinol
  参考文献：
  名称：

  Synthesis and antineoplastic activity of hydroquinone dialdehydes

  摘要：

  A number of hydroquinone dialdehydes and structurally related compounds were synthesized and tested for antineoplastic efficacy against transplanted murine tumors. 3,6-Dihydroxy-4,5-dimethylphthalaldehyde,3,6-dihydroxy-4,5-dipropylphthalaldehyde, and 3,6-dihydroxy-4,5-dimethylphthalaldehyde hemialdal tetraacetate significantly prolonged the survival time of mice bearing either Sarcoma 180, Ehrlich carcinoma, or adenocarcinoma 755 ascites tumors. In addition, these agents were cytotoxic to Sarcoma 180 cells in culture at concentrations in the range of 25-30 microM.

  DOI：

  10.1021/jm00180a009

文献信息

• BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS
  申请人：Billinton Andrew

  公开号：US20110201663A1

  公开（公告）日：2011-08-18

  A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R 1 R 2 R 3 , R 4 , R 5 , R 6 , X and Y are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.

  公式（I）的化合物或其药学上可接受的衍生物，其中，R1R2R3、R4、R5、R6、X和Y如规范中所定义；制备这种化合物的过程；包含这种化合物的制药组合物；以及这种化合物在医学上的应用。
• Thomson, Ronald H.; Worthington, Roger D., Journal of the Chemical Society. Perkin transactions I, 1980, p. 282 - 288
  作者：Thomson, Ronald H.、Worthington, Roger D.

  DOI：——

  日期：——
• THOMSON R. H.; WORTHINGTON R. D., J. CHEM. SOC. PERKIN TRANS., PART 1, 1980, NO 1, 282-288
  作者：THOMSON R. H.、 WORTHINGTON R. D.

  DOI：——

  日期：——
• NEWMAN E. M.; LIN AI JENG; SARTORELLI A. C., J. MED. CHEM., 1980, 23, NO 6, 627-631
  作者：NEWMAN E. M.、 LIN AI JENG、 SARTORELLI A. C.

  DOI：——

  日期：——