hydroquinone; hydrochloride | 5864-41-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: hydroquinone; hydrochloride
• 英文别名: Hydrochinon; Hydrochlorid；Hydroquinone hydrogen chloride；benzene-1,4-diol;hydrochloride
• CAS: 5864-41-5；14342-96-2；60776-06-9
• 化学式: 3C₆H₆O₂*ClH
• 分子量: 366.798
• InChiKey: RTBFZNKEWQAVEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.52
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.5
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对苯二酚 在 盐酸 、 乙醚 作用下， 生成 hydroquinone; hydrochloride
  参考文献：
  名称：

  Schmidlin; Lang, Chemische Berichte, 1910, vol. 43, p. 2819

  摘要：

  DOI：

文献信息

• [EN] ANALOGS OF BENZOQUINONE-CONTAINING ANSAMYCINS FOR THE TREATMENT OF CANCER<br/>[FR] ANALOGUES D'ANSAMYCINES CONTENANT DE LA BENZOQUINONE POUR LE TRAITEMENT DU CANCER
  申请人：INFINITY PHARMACEUTICALS INC

  公开号：WO2005063714A1

  公开（公告）日：2005-07-14

  The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer ( formula (I) and (IV). The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting (17)-­ammonium hydroquinone ansamycin analog.

  本发明提供了含苯醌的ansamycins的类似物及其用于治疗和调节与过度增殖相关的疾病，如癌症（公式（I）和（IV））。本发明提供了含苯醌的ansamycins的类似物，其中苯醌被还原为氢醌，并通过与适当酸反应而被困，最好是增加所得（17）-氨基氢醌ansamycin类似物的溶解性和空气稳定性的酸。
• [EN] METHODS OF TREATING LIPOSARCOMA<br/>[FR] PROCÉDÉS DE TRAITEMENT DU LIPOSARCOME
  申请人：INFINITY PHARMACEUTICALS INC

  公开号：WO2010135426A1

  公开（公告）日：2010-11-25

  Provided herein are methods of treating liposarcoma in a subject, the method comprising administering to the subject a therapeutically effective amount of an Hsp90 inhibitor.

  本文提供了一种治疗脂肪肉瘤的方法，该方法包括向受试者施用治疗有效量的Hsp90抑制剂。
• Analogs of benzoquinone-containing ansamycins and methods of use thereof
  申请人：Adams Julian

  公开号：US20050288269A1

  公开（公告）日：2005-12-29

  The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

  本发明提供含苯醌的ansamycins的类似物及其用于治疗和调节与过度增殖有关的疾病，如癌症。本发明提供的含苯醌的ansamycins的类似物中，苯醌被还原为氢醌，并通过与适当酸的反应被固定，优选增加所得17-铵盐氢醌ansamycin类似物的溶解度和空气稳定性的酸。
• ANALOGS OF BENZOQUINONE-CONTAINING ANSAMYCINS AND METHODS OF USE THEREOF
  申请人：Adams Julian

  公开号：US20090253653A1

  公开（公告）日：2009-10-08

  The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

  本发明提供了苯醌含有的ansamycins的类似物及其用于治疗和调节与高增殖相关的疾病，如癌症。本发明提供了苯醌含有的ansamycins的类似物，其中苯醌被还原为氢醌，并通过与适当酸反应被固定，优选那些增加所得到的17-铵氢醌ansamycin类似物的溶解度和空气稳定性的酸。
• Analogs of Benzoquinone-Containing Ansamycins and Methods of Use Thereof
  申请人：Adams Julian

  公开号：US20090062250A1

  公开（公告）日：2009-03-05

  The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

  本发明提供了苯醌含量的ansamycins的类似物及其用于治疗和调节与过度增殖有关的疾病，如癌症。本发明提供了苯醌含量的ansamycins的类似物，其中苯醌被还原为一个氢醌，并通过与适当酸的反应被固定，优选增加所得到的17-铵盐氢醌ansamycin类似物的溶解性和空气稳定性的酸。