1,7-Dimethyl-1,2,3,4-tetrahydro-1,8-naphthyrid-5-one | 60316-25-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1,7-Dimethyl-1,2,3,4-tetrahydro-1,8-naphthyrid-5-one
• 英文别名: 1,7-Dimethyl-5-oxo-1,2,3,4,5,8-hexahydro-1,8-naphthyridin；1,7-Dimethyl-1,2,3,4,5,8-hexahydro-naphthyrid-5-on；2,8-dimethyl-5,6,7,8-tetrahydro-1H-[1,8]naphthyridin-4-one；2,8-Dimethyl-1,5,6,7-tetrahydro-1,8-naphthyridin-4-one
• CAS: 60316-25-8
• 化学式: C₁₀H₁₄N₂O
• 分子量: 178.234
• InChiKey: IPVSUSPLIHILIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Pyridine derivatives as angiotensin II antagonists, processes for their preparation and pharmaceutical compositions containing them
  申请人：ZENECA LIMITED

  公开号：EP0499414A2

  公开（公告）日：1992-08-19

  The invention concerns pharmaceutically useful compounds of the formula I, in which R1, R2, R3, R4, n, m, X, Y and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.

  本发明涉及式 I 的药用化合物（其中 R1、R2、R3、R4、n、m、X、Y 和 Z 具有本文所定义的各种含义）及其无毒盐和含有它们的药物组合物。这些新型化合物具有治疗高血压和充血性心力衰竭等疾病的价值。本发明还涉及新型化合物的生产工艺以及这些化合物在医疗中的应用。
• US5198434A
  申请人：——

  公开号：US5198434A

  公开（公告）日：1993-03-30