N,N-dimethyl-2-(1-adamantyl)ethylamine | 162005-33-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-dimethyl-2-(1-adamantyl)ethylamine
• 英文别名: 1-(1-Adamantyl)-2-N,N-dimethylaminoethan；(1-Adamantylethyl)dimethylamine；2-(1-adamantyl)-N,N-dimethylethanamine
• CAS: 162005-33-6
• 化学式: C₁₄H₂₅N
• 分子量: 207.359
• InChiKey: JJAHUWQWZKRQSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N,N-dimethyl-2-(1-adamantyl)ethylamine 在 双氧水 作用下， 以 甲醇 为溶剂， 反应 30.0h， 生成 1-(1-金刚烷基)乙烯
  参考文献：
  名称：

  Preparation of homochiral crown ether containing (S)-1-(1-adamantyl)ethane-1,2-diol as a chiral subunit and its enantioselective complexation with an organic ammonium cation

  摘要：

  Homochiral 1-(1-adamantyl)ethane-1,2-diol(5) was prepared and its absolute configuration was determined to be (S)-(+)-5 by enzymatic and H-1 n.m.r. spectroscopic methods. Using (S)-(+)-5 as a chiral subunit, the homochiral crown ether (+)-18 was synthesized and its enantioselectivity in complexation of methionine methyl ester perchlorate was also examined by the H-1 n.m.r. spectroscopic method.

  DOI：

  10.1016/0957-4166(94)80125-8
• 作为产物：
  描述：

  1-金刚烷乙酰氯 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 N,N-dimethyl-2-(1-adamantyl)ethylamine
  参考文献：
  名称：

  金刚烷烷胺类可能作为抗抑郁药和抗帕金森氏剂。

  摘要：

  DOI：

  10.1021/jm00252a007

文献信息

• Chemistry of adamantane. VII. Adamantanealkanamines as potential antidepressant and anti-Parkinson agents
  作者：Jiban K. Chakrabarti、Michael J. Foulis、Terrence M. Hotten、Stephen S. Szinai、Alec Todd

  DOI：10.1021/jm00252a007

  日期：1974.6
• [EN] ONE-POT SYNTHESIS OF METAL-EXCHANGED ZEOLITIC MATERIALS<br/>[FR] SYNTHÈSE MONOTOPE DE MATÉRIAUX ZÉOLITIQUES À ÉCHANGE DE MÉTAL
  申请人：BASF SE

  公开号：WO2020225419A1

  公开（公告）日：2020-11-12

  The present invention relates to a process for the preparation of a metal-exchanged zeolitic material comprising SiO2 and X2O3 in its framework structure, wherein X is a trivalent element, comprising (1) preparing a first mixture comprising one or more nonpolar organic solvents, one or more polar protic solvents, one or more organotemplates as structure directing agents, one or more bases, and optionally one or more emulsifiers; (2) emulsifying said mixture; (3) adding one or more sources of SiO2 to the emulsified mixture; (4) preparing a second mixture comprising one or more nonpolar organic solvents; (5) adding one or more sources of a metal M to the second mixture; (6) adding the second mixture to the first mixture; (7) heating the mixture obtained in (6) for crystallizing, and wherein the first mixture prepared in (1) and/or the second mixture prepared in (4) further comprises one or more sources of X2O3. Further, the present invention relates to a metal-exchanged zeolitic material and use thereof.
• Preparation of homochiral crown ether containing (S)-1-(1-adamantyl)ethane-1,2-diol as a chiral subunit and its enantioselective complexation with an organic ammonium cation
  作者：Koichiro Naemura、Takashi Mizo-oku、Kimiko Kamada、Keiji Hirose、Yoshito Tobe、Masami Sawada、Yoshio Takai

  DOI：10.1016/0957-4166(94)80125-8

  日期：1994.8

  Homochiral 1-(1-adamantyl)ethane-1,2-diol(5) was prepared and its absolute configuration was determined to be (S)-(+)-5 by enzymatic and H-1 n.m.r. spectroscopic methods. Using (S)-(+)-5 as a chiral subunit, the homochiral crown ether (+)-18 was synthesized and its enantioselectivity in complexation of methionine methyl ester perchlorate was also examined by the H-1 n.m.r. spectroscopic method.