甲基[4-[(1-氨基-9,10-二氢-4-羟基-9,10-二羰基-2-蒽基)氧代]苯氧基]乙酸酯 | 52455-32-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 甲基[4-[(1-氨基-9,10-二氢-4-羟基-9,10-二羰基-2-蒽基)氧代]苯氧基]乙酸酯
• 英文名称: Adrenaline sulfate
• 英文别名: 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol;sulfuric acid
• CAS: 52455-32-0
• 化学式: C9H15NO7S
• 分子量: 281.29
• InChiKey: NDOXJVMFOWUYBP-FVGYRXGTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  156
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• Method of administration and treatment
  申请人：AMPERSAND BIOPHARMACEUTICALS, INC.

  公开号：US10632146B2

  公开（公告）日：2020-04-28

  Provided herein are formulations for topical and/or transdermal administration, and methods of using these formulations for the treatment of proliferative diseases related to cancer such as cancers and related conditions, and solid tumors. Also provided are formulations for topical and/or transdermal administration, and methods of using these formulations for melasma, gout, skin disorders, and other diseases and disorders described herein as well as methods for modulating the pH (e.g. raising) of a tissue or microenvironment proximal to a tumor, modulating pH, or improving the effectiveness of know chemotherapeutic agents, immunotherapy and the like for the prevention, treatment of cancers and related conditions described herein.

  本文提供了用于局部和/或透皮给药的制剂，以及使用这些制剂治疗与癌症有关的增殖性疾病（如癌症和相关疾病以及实体瘤）的方法。还提供了用于局部和/或透皮给药的制剂，以及使用这些制剂治疗黄褐斑、痛风、皮肤病和本文所述的其他疾病和失调的方法，以及用于调节肿瘤近端组织或微环境的 pH 值（例如升高）、调节 pH 值或提高已知化疗药物、免疫疗法等的有效性以预防、治疗本文所述的癌症和相关疾病的方法。
• Transdermal carrier
  申请人：Ampersand Biopharmaceuticals, Inc.

  公开号：US10814003B2

  公开（公告）日：2020-10-27

  Improved formulations for topical treatment that ensure at least localized transdermal or systemic delivery of an active agent through skin, nails or hair follicles are disclosed.

  本发明公开了用于局部治疗的改进配方，可确保至少通过皮肤、指甲或毛囊局部透皮或全身输送活性剂。
• Transdermal penetrant formulations containing cannabidiol
  申请人：AMPERSAND BIOPHARMACEUTICALS, INC.

  公开号：US10842758B1

  公开（公告）日：2020-11-24

  Disclosed herein is a transdermal delivery formulation for transdermal delivery of a Cannabidiol, with or without one or more additional active agents through the dermis, including the skin, nail or hair follicle of a subject, wherein the formulation comprises a) a transdermal delivery formulation in an amount less than about 60% w/w, comprising i. one or more phosphatides, ii. glucose, and iii. one or more fatty acids; b) water in an amount less than about 50% w/w, a Cannabidiol with or within one or more additional active agents.

  本文公开了一种透皮给药配方，用于通过真皮（包括受试者的皮肤、指甲或毛囊）透皮给药大麻二酚（含或不含一种或多种额外活性剂），其中该配方包括 a) 含量小于约 60% w/w 的透皮给药配方，包含 i. 一种或多种磷脂，ii. 葡萄糖，iii. 一种或多种脂肪酸；b) 含量小于约 50% w/w 的水，大麻二酚（含或不含一种或多种额外活性剂）。
• Stable aqueous injectable solution of epinephrine
  申请人：SUN PHARMACEUTICAL INDUSTRIES LIMITED

  公开号：US11234925B2

  公开（公告）日：2022-02-01

  The present invention provides a stable, aqueous injectable solution comprising epinephrine or its pharmaceutically acceptable salt, a sulfite antioxidant, butylated hydroxyl anisole, an organic acid and a chelating agent, wherein the solution is free of an inorganic acid and an inorganic base. The invention also provides a method of treating the septic shock by intravenous administration of stable aqueous injectable solution comprising epinephrine or its pharmaceutically acceptable salt, a sulfite antioxidant, butylated hydroxyl anisole, an organic acid and a chelating agent, wherein the solution is free of an inorganic acid and an inorganic base.

  本发明提供了一种稳定的可注射水溶液，包含肾上腺素或其药学上可接受的盐、亚硫酸盐抗氧化剂、丁基化羟基苯甲醚、有机酸和螯合剂，其中该溶液不含无机酸和无机碱。本发明还提供了一种治疗脓毒性休克的方法，通过静脉注射稳定的可注射水溶液，该溶液包含肾上腺素或其药学上可接受的盐、亚硫酸盐抗氧化剂、丁基化羟基苯甲醚、有机酸和螯合剂，其中溶液不含无机酸和无机碱。
• METHODS AND FORMULATIONS FOR TRANSDERMAL ADMINISTRATION
  申请人：Intellectual Property Associates, LLC

  公开号：EP3236903B1

  公开（公告）日：2021-04-21