3-Cyclohexyloxyprop-2-ynyl ethyl carbonate | 290833-30-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: 3-Cyclohexyloxyprop-2-ynyl ethyl carbonate
• CAS: 290833-30-6
• 化学式: C₁₂H₁₈O₄
• 分子量: 226.273
• InChiKey: SPPDURWNSQCRST-UHFFFAOYSA-N

物化性质

• 沸点：
  304.8±21.0 °C(Predicted)
• 密度：
  1.08±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-Cyclohexyloxyprop-2-ynyl ethyl carbonate 在 盐酸 、 diisopropoxy(η2-propene) titanium(II) complex 、 异丙基氯化镁 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Preparation of Titanated Alkoxyallenes from 3-Alkoxy-2-propyn-1-yl Carbonates and (η²-Propene)Ti(O-i-Pr)₂ as an Efficient Ester Homoaldol Equivalent

  摘要：

  [GRAPHICS]3-Alkoxy-2-propyn-1-yl carbonates (2) react with a divalent titanium reagent (eta(2)-propene)Ti(O-i-Pr)(2) to afford titanated alkoxyallenes 1 which, in turn, react with aldehydes regiospecifically to provide the corresponding gamma-addition products in good to excellent yields, thus affording a convenient method for synthesizing gamma-hydroxy esters 3 and/or gamma-butyrolactones 4.

  DOI：

  10.1021/ol006142f
• 作为产物：
  描述：

  环己醇 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 生成 3-Cyclohexyloxyprop-2-ynyl ethyl carbonate
  参考文献：
  名称：

  Preparation of Titanated Alkoxyallenes from 3-Alkoxy-2-propyn-1-yl Carbonates and (η²-Propene)Ti(O-i-Pr)₂ as an Efficient Ester Homoaldol Equivalent

  摘要：

  [GRAPHICS]3-Alkoxy-2-propyn-1-yl carbonates (2) react with a divalent titanium reagent (eta(2)-propene)Ti(O-i-Pr)(2) to afford titanated alkoxyallenes 1 which, in turn, react with aldehydes regiospecifically to provide the corresponding gamma-addition products in good to excellent yields, thus affording a convenient method for synthesizing gamma-hydroxy esters 3 and/or gamma-butyrolactones 4.

  DOI：

  10.1021/ol006142f

文献信息

• Preparation of Titanated Alkoxyallenes from 3-Alkoxy-2-propyn-1-yl Carbonates and (η²-Propene)Ti(O-<i>i</i>-Pr)₂ as an Efficient Ester Homoaldol Equivalent
  作者：Takeshi Hanazawa、Sentaro Okamoto、Fumie Sato

  DOI：10.1021/ol006142f

  日期：2000.7.1

  [GRAPHICS]3-Alkoxy-2-propyn-1-yl carbonates (2) react with a divalent titanium reagent (eta(2)-propene)Ti(O-i-Pr)(2) to afford titanated alkoxyallenes 1 which, in turn, react with aldehydes regiospecifically to provide the corresponding gamma-addition products in good to excellent yields, thus affording a convenient method for synthesizing gamma-hydroxy esters 3 and/or gamma-butyrolactones 4.