Imidazo<4,5-h>isochinolin | 56623-95-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: Imidazo<4,5-h>isochinolin
• 英文别名: 1(3)H-imidazo[4,5-h]isoquinoline；1H-Imidazo[4,5-H]isoquinoline；3H-imidazo[4,5-h]isoquinoline
• CAS: 56623-95-1
• 化学式: C₁₀H₇N₃
• mdl: MFCD20617567
• 分子量: 169.186
• InChiKey: GQSHFYGCUBUDCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Imidazo<4,5-h>isochinolin 以85%的产率得到
  参考文献：
  名称：

  LEBENSTEDT E.; SCHUNACK W., ARCH. PHARM. , 1975, 308, NO 6, 413-417

  摘要：

  DOI：

文献信息

• [EN] DIHYDROIMIDAZOISOQUINOLINE DERIVATIVES USEFUL AS PDE10 INHIBITORS<br/>[FR] DÉRIVÉS DE DIHYDROIMIDAZOISOQUINOLÉINE UTILES EN TANT QU'INHIBITEURS DE PDE10
  申请人：SCHERING CORP

  公开号：WO2011008597A1

  公开（公告）日：2011-01-20

  The present invention relates to dihydroimidazoisoquinolines and derivatives thereof, the use of the compounds as phosphodiesterase 10 (PDE10) inhibitors for the treatment of PDE10-modulated disorders, to pharmaceutical compositions comprising the compounds.

  本发明涉及二氢咪唑异喹啉及其衍生物，所述化合物作为磷酸二酯酶10（PDE10）抑制剂用于治疗PDE10调节的疾病，以及包含该化合物的药物组合物。
• [EN] IMIDAZOISOQUINOLINE COMPOUNDS, COMPOSITIONS COMPRISING THE COMPOUNDS AND THEIR USE FOR CONTROLLING INVERTEBRATE PESTS<br/>[FR] COMPOSÉS IMIDAZOISOQUINOLÉINE, COMPOSITIONS COMPRENANT LES COMPOSÉS ET LEUR UTILISATION POUR LUTTER CONTRE DES ORGANISMES NUISIBLES INVERTÉBRÉS
  申请人：BASF SE

  公开号：WO2016113271A1

  公开（公告）日：2016-07-21

  The present invention relates to novel imidazoisoquinoline compounds of the formula I and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein A1 is N or C(R2), A2 is N or C(R3); A3 is N or C(R4); A4 is N or C(R5); A5 is N or C(R6); and where Ar, R, R1, R2, R3, R4,R5 and R6 are as defined in the claims. The compounds of formula (I), as well as the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof, are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.

  本发明涉及具有以下结构的新型咪唑异喹啉化合物及其N-氧化物、立体异构体、互变异构体和农业或兽医可接受的盐：其中A1为N或C(R2)，A2为N或C(R3)；A3为N或C(R4)；A4为N或C(R5)；A5为N或C(R6)；Ar、R、R1、R2、R3、R4、R5和R6的定义如索赔中所述。式(I)的化合物及其N-氧化物、立体异构体、互变异构体和农业或兽医可接受的盐，可用于对抗或控制无脊椎动物害虫，特别是节肢动物害虫和线虫。该发明还涉及一种利用这些化合物控制无脊椎动物害虫的方法，以及包含所述化合物的植物繁殖材料和农业和兽医组合物。
• Imidazoloisoquinolines
  申请人：Neurogen Corporation

  公开号：US20020019410A1

  公开（公告）日：2002-02-14

  Disclosed are compounds of the formula: 1 and the pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein n, R 1 , R 2 , R 3 , W, Q, and X are defined herein, which compounds bind with high selectivity and high affinity to the benzodiazepine site of the GABA A receptors and are therefore useful in the treatment of certain central nervous system (CNS) diseases and as probes for the localization of GABA A receptors in tissue samples.

  本发明公开了公式1的化合物及其药学上可接受的盐、前药和溶剂化物，其中n、R1、R2、R3、W、Q和X在此定义，这些化合物具有高选择性和高亲和力与GABA A受体的苯二氮平位点结合，因此在治疗某些中枢神经系统（CNS）疾病和作为探针用于组织样本中的GABA A受体的定位中有用。
• METAL COMPLEXES
  申请人：Stoessel Philipp

  公开号：US20130082209A1

  公开（公告）日：2013-04-04

  The present invention relates to metal complexes and to elec tronic devices, in particular organic electroluminescent devices, com-pris ing these metal complexes. M(L)n(L′)m (formula 1), where the compound of the gene ral formula (1) contains a moiety M(L)n of the formula (2).

  本发明涉及金属配合物和电子设备，特别是包含这些金属配合物的有机电致发光器件。其中，通式（1）的化合物包含式（2）的M(L)n基团。
• ORGANIC ELECTROLUMINESCENT DEVICE
  申请人：Parham Amir Hossain

  公开号：US20140088305A1

  公开（公告）日：2014-03-27

  The present invention relates to organic electroluminescent devices which comprise heteroaromatic compounds.

  本发明涉及包含杂环芳香化合物的有机电致发光器件。