4-(5-methoxy-8-hydroxynaphthalen-1-yloxy)naphth-1-ol | 521285-24-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(5-methoxy-8-hydroxynaphthalen-1-yloxy)naphth-1-ol
• 英文别名: 8-(4-Hydroxynaphthalen-1-yl)oxy-4-methoxynaphthalen-1-ol
• CAS: 521285-24-5
• 化学式: C₂₁H₁₆O₄
• 分子量: 332.356
• InChiKey: FTLRHGBJMZKBEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(5-methoxy-8-hydroxynaphthalen-1-yloxy)naphth-1-ol 在 碘苯二乙酸 作用下， 以 乙腈 为溶剂， 反应 0.5h， 以55%的产率得到1-oxo-1,4-dihydronaphthalene-4-spiro-2'-naphtho[4''-methoxy-[1'',8''-de][1',3']]dioxin
  参考文献：
  名称：

  Synthesis of Highly Oxygenated Dinaphthyl Ethers via S_NAr Reactions Promoted by Barton's Base

  摘要：

  [GRAPHIC]Electron-rich dinaphthyl ethers were synthesized by SNAr reactions between naphthols and activated fluoronaphthalenes. 2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton's base) was found to be an excellent, mild alternative to traditional inorganic bases for promoting the coupling reaction.

  DOI：

  10.1021/ol034286z
• 作为产物：
  描述：

  4-氟-1-萘醛 在 2-叔丁基-1,1,3,3-四甲基胍 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 18.25h， 生成 4-(5-methoxy-8-hydroxynaphthalen-1-yloxy)naphth-1-ol
  参考文献：
  名称：

  Synthesis of Highly Oxygenated Dinaphthyl Ethers via S_NAr Reactions Promoted by Barton's Base

  摘要：

  [GRAPHIC]Electron-rich dinaphthyl ethers were synthesized by SNAr reactions between naphthols and activated fluoronaphthalenes. 2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton's base) was found to be an excellent, mild alternative to traditional inorganic bases for promoting the coupling reaction.

  DOI：

  10.1021/ol034286z

文献信息

• Synthesis of Highly Oxygenated Dinaphthyl Ethers via S_NAr Reactions Promoted by Barton's Base
  作者：Peter Wipf、Stephen M. Lynch

  DOI：10.1021/ol034286z

  日期：2003.4.1

  [GRAPHIC]Electron-rich dinaphthyl ethers were synthesized by SNAr reactions between naphthols and activated fluoronaphthalenes. 2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton's base) was found to be an excellent, mild alternative to traditional inorganic bases for promoting the coupling reaction.