(E)-3-((2-hydroxynaphthalen-1-yl)methyleneamino)-2-methylquinazoline-4(3H)-one | 1613228-58-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (E)-3-((2-hydroxynaphthalen-1-yl)methyleneamino)-2-methylquinazoline-4(3H)-one
• 英文别名: 3-{[(E)-(2-hydroxynaphthalen-1-yl)methylidene]amino}-2-methylquinazolin-4(3H)-one；3-[(E)-(2-hydroxynaphthalen-1-yl)methylideneamino]-2-methylquinazolin-4-one
• CAS: 1613228-58-2
• 化学式: C₂₀H₁₅N₃O₂
• 分子量: 329.358
• InChiKey: JGLXBMHDKKBLJV-CIAFOILYSA-N

物化性质

• 沸点：
  559.5±52.0 °C(Predicted)
• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  65.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  lanthanum(III) chloride 、 (E)-3-((2-hydroxynaphthalen-1-yl)methyleneamino)-2-methylquinazoline-4(3H)-one 、 水 以 甲醇 为溶剂， 反应 3.0h， 以78%的产率得到
  参考文献：
  名称：

  La(III) complex involving the O,N-donor environment of quinazoline-4(3H)-one Schiff’s base and their antimicrobial attributes against methicillin-resistant Staphylococcus aureus (MRSA)

  摘要：

  The incidence of methicillin-resistant Staphylococcus aureus increased during the past few decades, so there is an urgent need of new antimicrobial agents if public health is concerned. Though the Schiffs bases and La(III) complex have enormous biological activity, but less attention was given in their synthesis. In the present investigation, we synthesized a new (E)-3-((2-hydroxynaphthalen-1-yl) methyleneamino)-2-methylquinazoline-4(3H)-one HNMAMQ Schiffs base by the condensation of 3-(2-aminophenyl) quinazolin-2-methyl-4(3H)-one and 2-hydroxy-1-naphthaldehyde. The Schiffs base HNMAMQ and its La(III) complex were characterized by elemental analyses, IR, NMR, mass spectra, and thermal studies. The newly synthesized Schiffs base HNMAMQ and its La(III) complex were evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from the Gulbarga region in India. The Schiffs base HNMAMQ and its La(III) complex showed good antimicrobial activity and thus represents a potential new drug of choice. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2014.03.115
• 作为产物：
  描述：

  邻氨基苯甲酸甲酯 在 一水合肼 作用下， 以 甲醇 为溶剂， 生成 (E)-3-((2-hydroxynaphthalen-1-yl)methyleneamino)-2-methylquinazoline-4(3H)-one
  参考文献：
  名称：

  La(III) complex involving the O,N-donor environment of quinazoline-4(3H)-one Schiff’s base and their antimicrobial attributes against methicillin-resistant Staphylococcus aureus (MRSA)

  摘要：

  The incidence of methicillin-resistant Staphylococcus aureus increased during the past few decades, so there is an urgent need of new antimicrobial agents if public health is concerned. Though the Schiffs bases and La(III) complex have enormous biological activity, but less attention was given in their synthesis. In the present investigation, we synthesized a new (E)-3-((2-hydroxynaphthalen-1-yl) methyleneamino)-2-methylquinazoline-4(3H)-one HNMAMQ Schiffs base by the condensation of 3-(2-aminophenyl) quinazolin-2-methyl-4(3H)-one and 2-hydroxy-1-naphthaldehyde. The Schiffs base HNMAMQ and its La(III) complex were characterized by elemental analyses, IR, NMR, mass spectra, and thermal studies. The newly synthesized Schiffs base HNMAMQ and its La(III) complex were evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from the Gulbarga region in India. The Schiffs base HNMAMQ and its La(III) complex showed good antimicrobial activity and thus represents a potential new drug of choice. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2014.03.115

文献信息

• DRUGS TO PREVENT HPV INFECTION
  申请人：Lambert Paul F.

  公开号：US20110165220A1

  公开（公告）日：2011-07-07

  A method of inhibiting HPV virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of a compound selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14. In another embodiment, the method involves administering an inhibitor selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14 to a susceptible tissue or cell.
• US9066951B2
  申请人：——

  公开号：US9066951B2

  公开（公告）日：2015-06-30
• US9949980B2
  申请人：——

  公开号：US9949980B2

  公开（公告）日：2018-04-24
• La(III) complex involving the O,N-donor environment of quinazoline-4(3H)-one Schiff’s base and their antimicrobial attributes against methicillin-resistant Staphylococcus aureus (MRSA)
  作者：K. Siddappa、Sunilkumar B. Mane、Deene Manikprabhu

  DOI：10.1016/j.saa.2014.03.115

  日期：2014.9

  The incidence of methicillin-resistant Staphylococcus aureus increased during the past few decades, so there is an urgent need of new antimicrobial agents if public health is concerned. Though the Schiffs bases and La(III) complex have enormous biological activity, but less attention was given in their synthesis. In the present investigation, we synthesized a new (E)-3-((2-hydroxynaphthalen-1-yl) methyleneamino)-2-methylquinazoline-4(3H)-one HNMAMQ Schiffs base by the condensation of 3-(2-aminophenyl) quinazolin-2-methyl-4(3H)-one and 2-hydroxy-1-naphthaldehyde. The Schiffs base HNMAMQ and its La(III) complex were characterized by elemental analyses, IR, NMR, mass spectra, and thermal studies. The newly synthesized Schiffs base HNMAMQ and its La(III) complex were evaluated for their antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from the Gulbarga region in India. The Schiffs base HNMAMQ and its La(III) complex showed good antimicrobial activity and thus represents a potential new drug of choice. (C) 2014 Elsevier B.V. All rights reserved.