N-propylcyclooctanamine | 39099-12-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-propylcyclooctanamine
• CAS: 39099-12-2
• 化学式: C₁₁H₂₃N
• mdl: MFCD11127804
• 分子量: 169.31
• InChiKey: ODBVEGWTXOEBIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-propylcyclooctanamine 、 bis(methoxycarbonyl)(phenyliodinio)methanide 以 1,4-二氧六环 、 甲苯 为溶剂， 反应 0.33h， 以42%的产率得到
  参考文献：
  名称：

  Direct Use of Unprotected Aliphatic Amines to Generate N-Heterocycles via β-C–H Malonylation with Iodonium Ylide

  摘要：

  An unprecedented method that enables the direct transformation of unprotected secondary aliphatic amines into functionalized N-heterocycles in the absence of transition metals was developed. The activation of these NH-free amines by the iodonium ylide induces a site-selective beta-C-H malonylation process, allowing the construction of three sigma-bonds and one pi-bond in a simple operation.

  DOI：

  10.1021/acs.orglett.9b04213

文献信息

• METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE BY MEANS OF COUPLING METHOD USING PALLADIUM COMPOUND
  申请人：Komiyama Masato

  公开号：US20130158272A1

  公开（公告）日：2013-06-20

  The present invention provides a method for producing a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or intermediates of the same, said method being efficient and using a short process. The present invention is a novel coupling method for obtaining a compound represented by formula (3) by bringing about a coupling reaction between a compound represented by formula (1) and a compound represented by formula (2), in the presence of a palladium compound, a ligand capable of coordinating to the palladium compound, a base, a C 1 -C 40 carboxylic acid, and at least one kind of additive.

  本发明提供了一种生产黄嘌呤氧化酶抑制剂的方法，该抑制剂是治疗高尿酸血症的药物，或者其中间体，该方法高效且使用流程简短。本发明是一种新型耦合方法，通过在钯化合物、能够配位到钯化合物的配体、碱、C1-C40羧酸和至少一种添加剂的存在下，在式（1）所代表的化合物和式（2）所代表的化合物之间引发耦合反应，从而获得式（3）所代表的化合物。
• Highly Active Mononuclear NAC-Gold(I) Catalysts
  作者：Maria Camila Blanco Jaimes、Constantin R. N. Böhling、Juan Manuel Serrano-Becerra、A. Stephen K. Hashmi

  DOI：10.1002/anie.201210351

  日期：2013.7.29

  One gold is enough: Mononuclear, homogeneous gold catalysts displayed excellent catalytic activity on the order of that previously reported for gold nanoparticle catalysts and surface‐bound gold complexes. In the model synthesis of spiro compounds (see picture) extremely high turnover numbers were achieved with only 0.000001 mol % of a silsesquioxane‐substituted catalyst.

  一金就足够了：单核均质金催化剂显示出优异的催化活性，其活性与先前报道的金纳米颗粒催化剂和表面结合金络合物的数量级相当。在螺环化合物的模型合成中（参见图片），仅用0.000001 mol％的倍半硅氧烷取代的催化剂即可实现极高的周转率。
• Aqueous ink composition for use in an ink-jet printer
  申请人：SEIKO EPSON CORPORATION

  公开号：EP0838508A2

  公开（公告）日：1998-04-29

  An aqueous ink composition for ink jet printers, which gives reliable printing performance and yields printed images which have excellent print quality and which dry rapidly is disclosed. The ink compositions are suitable for printing on plain paper. The ink comprises water as the principal solvent, an anionic colorant, pectic acid, a base, and at least one of a penetrable solvent and/or a penetrability-imparting surfactant. The pectic acid is composed primarily of α-1,4 linked polygalacturonic acid having a degree of esterification not more than 5% where the degree of esterification is defined as the percentage of the total number of galacturonic acid units in the pectic acid which are esterified.

  本发明公开了一种用于喷墨打印机的水性油墨组合物，该组合物具有可靠的打印性能，可打印出打印质量极佳且干燥迅速的图像。这种油墨组合物适用于在普通纸上打印。油墨包括作为主溶剂的水、阴离子着色剂、果胶酸、碱和至少一种可渗透溶剂和/或渗透性促进表面活性剂。果胶酸主要由α-1,4 连接的聚半乳糖醛酸组成，其酯化程度不超过 5%，其中酯化程度定义为果胶酸中酯化的半乳糖醛酸单位总数的百分比。
• METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE BY MEANS OF COUPLING METHOD USING A PALLADIUM COMPOUND
  申请人：Teijin Pharma Limited

  公开号：EP2610248A1

  公开（公告）日：2013-07-03

  The present invention provides a method for producing a xanthine oxidase inhibitor, which is a therapeutic agent for hyperuricemia, or intermediates of the same, said method being efficient and using a short process. The present invention is a novel coupling method for obtaining a compound represented by formula (3) by bringing about a coupling reaction between a compound represented by formula (1) and a compound represented by formula (2), in the presence of a palladium compound, a ligand capable of coordinating to the palladium compound, a base, a C1-C40 carboxylic acid, and at least one kind of additive.

  本发明提供了一种生产作为高尿酸血症治疗药物的黄嘌呤氧化酶抑制剂或其中间体的方法，所述方法高效且工艺流程短。本发明是一种新颖的偶联方法，通过在钯化合物、能与钯化合物配位的配体、碱、C1-C40 羧酸和至少一种添加剂存在下，使式（1）代表的化合物与式（2）代表的化合物发生偶联反应，得到式（3）代表的化合物。
• Hydrogen sulfide imaging system
  申请人：REBELLION PHOTONICS, INC.

  公开号：US10648960B2

  公开（公告）日：2020-05-12

  Various embodiments disclosed herein describe an infrared (IR) imaging system for detecting a gas. The imaging system can include an optical filter that selectively passes light having a wavelength in a range of 1585 nm to 1595 nm while attenuating light at wavelengths above 1600 nm and below 1580 nm. The system can include an optical detector array sensitive to light having a wavelength of 1590 that is positioned rear of the optical filter.

  本文公开的各种实施例描述了一种用于检测气体的红外（IR）成像系统。该成像系统可包括一个光学滤光器，该滤光器可选择性地通过波长在 1585 纳米到 1595 纳米范围内的光，同时衰减波长高于 1600 纳米和低于 1580 纳米的光。该系统可包括一个对波长为 1590 的光敏感的光学检测器阵列，该阵列位于光学滤波器的后方。