Phenol, 2-methoxy-4-[(pentyloxy)methyl]- | 81995-40-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Phenol, 2-methoxy-4-[(pentyloxy)methyl]-
• 英文别名: 2-methoxy-4-(pentoxymethyl)phenol
• CAS: 81995-40-6
• 化学式: C₁₃H₂₀O₃
• 分子量: 224.3
• InChiKey: JRZRPDSRRGEVTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• METHYL MENTHOL DERIVATIVE AND COOLING AGENT COMPOSITION CONTAINING SAME
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20180057447A1

  公开（公告）日：2018-03-01

  The purpose of the present invention is to provide a cooling agent composition containing a novel methyl menthol derivative having no undesirable feeling of stimulation, malodor, bitterness, or the like, it being possible to use the cooling agent composition as a cooling agent or sensory stimulation agent having exceptional persistence of a sense of coolness and refreshing feeling. The present invention pertains to a cooling agent composition containing a methyl menthol derivative represented by general formula (1A) or general formula (1B).

  本发明的目的是提供一种冷却剂组合物，其中包含一种新型的甲基薄荷醇衍生物，不具有刺激感、恶臭、苦味等不良感觉，可以将该冷却剂组合物用作具有出色持久感觉的凉爽和清新感的冷却剂或感官刺激剂。本发明涉及一种含有由通式（1A）或通式（1B）表示的甲基薄荷醇衍生物的冷却剂组合物。
• COOL-SENSATION IMPARTER COMPOSITION CONTAINING 2,2,6-TRIMETHYLCYCLOHEXANECARBOXYLIC ACID DERIVATIVE
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20200297607A1

  公开（公告）日：2020-09-24

  A cooling agent composition contains a 2,2,6-trimethylcyclohexanecarboxylic acid derivative represented by the following general formula (1). The symbol * represents an asymmetric carbon atom. X represents NH, N(ZAr 2 ), O or S, Z represents a single bond or an alkylene group having 1 to 3 carbon atoms which may have a substituent, Ar 2 represents an aryl group having 6 to 20 carbon atoms which may have a substituent or an aromatic heterocyclic group having 2 to 15 carbon atoms which may have a substituent. Y each independently represents a methylene group which may have a substituent, and n represents an integer of 0 to 3. Ar 1 represents an aryl group having 6 to 20 carbon atoms which may have a substituent or an aromatic heterocyclic group having 2 to 15 carbon atoms which may have a substituent.

  一个制冷剂组合物包含一个由以下通用式（1）表示的2,2,6-三甲基环己烷羧酸衍生物。符号*代表一个不对称碳原子。X代表NH，N(ZAr2)，O或S，Z代表一个单键或一个具有1到3个碳原子的烷基基团，可以有一个取代基，Ar2代表一个具有6到20个碳原子的芳基基团，可以有一个取代基或一个具有2到15个碳原子的芳香杂环基团，可以有一个取代基。Y各自独立地表示一个可以有取代基的亚甲基基团，n表示0到3的整数。Ar1代表一个具有6到20个碳原子的芳基基团，可以有一个取代基或一个具有2到15个碳原子的芳香杂环基团，可以有一个取代基。
• Topically applied circulation enhancing agent and skin and hair cosmetic and bath agent containing the same
  申请人：Sagawa Koichiro

  公开号：US20060287390A1

  公开（公告）日：2006-12-21

  A topically applied circulation enhancing agent suited for application over the entire body which has good transdermal absorptivity and causes little irritation is provided. A topically applied circulation enhancing agent is provided which contains a fatty acid ester denoted by general formula (1):

  提供一种适用于全身涂抹的促进循环的药剂，具有良好的经皮吸收性且引起少量刺激。提供一种含有一种由通用公式(1)表示的脂肪酸酯的促进循环的局部应用药剂。
• SYNTHETIC SPILANTHOL AND USE THEREOF
  申请人：Lombardo Louis

  公开号：US20100184863A1

  公开（公告）日：2010-07-22

  The present application provides a synthetic spilanthol flavor composition that includes (2E,6Z,8E)-N-(2-methylpropyl)-2,6,8-decatrienamide. The synthetic spilanthol composition can also contain, and at least one of (2E, 6E, 8E)-N-(2-methylpropyl)-2,6,8-decatrienamide and (2E, 6Z, 8Z)-N-(2-methylpropyl)-2,6,8-decatrienamide, the (N-(2-methylpropyl)-2,6,8-decatrienamide being present in amounts effective to impart a salivating or tingle effect while reducing the perception of off notes, as compared to the off-notes perceived upon consumption of natural spilanthol (e.g. spilanthol obtained from jambu oleoresin). Methods of increasing salivation and/or providing a tingling sensation upon consuming an orally consumable product that include adding to the product a synthetic spilanthol flavor composition are also provided. Synthetic spilanthol flavor compositions can be added to orally consumed products, such as, but not limited to, foods, beverages, pharmaceuticals, nutraceuticals, or therapeutic compositions, oral personal care products, gums (e.g. chewing gum or bubble gum), candy or lozenges.

  本申请提供一种合成的牙齿花酚香味组合物，其中包括（2E，6Z，8E）-N-（2-甲基丙基）-2，6，8-癸烯酰胺。合成的牙齿花酚组合物还可以包含至少一种（2E，6E，8E）-N-（2-甲基丙基）-2，6，8-癸烯酰胺和（2E，6Z，8Z）-N-（2-甲基丙基）-2，6，8-癸烯酰胺，其中（N-（2-甲基丙基）-2，6，8-癸烯酰胺）的含量有效地赋予口腔产生流口水或刺痛的效果，同时减少了与天然牙齿花酚（例如从jambu oleoresin获得的牙齿花酚）消费时感知到的异味。还提供了通过向可口服产品中添加合成的牙齿花酚香味组合物来增加口腔分泌和/或提供刺痛感的方法。合成的牙齿花酚香味组合物可以添加到口服产品中，例如但不限于食品、饮料、药品、保健品或治疗组合物、口腔个人护理产品、口香糖（例如嚼口香糖或泡泡糖）、糖果或含片中。
• FLAVOR COMPOSITION CONTAINING FLAVONE GLYCOSIDES
  申请人：Bardsley Kathryn

  公开号：US20120251465A1

  公开（公告）日：2012-10-04

  The present invention has discovered that flavone glycosides represented by Formula I set forth below have unexpected and advantageous flavor enhancement and modification properties: wherein R 1 is selected from the group consisting of H and CH 3 , R 2 is selected from the group consisting of H and OH, and R 3 is a 7-O-glycoside. Thus, the flavone glycosides of the present invention can be used to enhance or modify the flavor of orally consumable compositions, such as foodstuff, chewing gums, dental and oral hygiene products, and medicinal products.

  本发明发现了以下公式I所表示的黄酮苷具有意外和优越的口味增强和修改特性：其中R1选择自H和CH3的群组，R2选择自H和OH的群组，R3是7-O-糖苷。因此，本发明的黄酮苷可用于增强或修改口服组合物的口味，如食品、口香糖、口腔卫生产品和药品。