6-nitro-7-(4-oxo-4H-pyridin-1-yl)-1,4-dihydroquinoxaline-2,3-dione | 172455-08-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 6-nitro-7-(4-oxo-4H-pyridin-1-yl)-1,4-dihydroquinoxaline-2,3-dione
• 英文别名: 6-nitro-7-(4-oxopyridin-1-yl)-1,4-dihydroquinoxaline-2,3-dione
• CAS: 172455-08-2
• 化学式: C₁₃H₈N₄O₅
• 分子量: 300.23
• InChiKey: MFWBPQYSXPQJNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  6-(4-oxo-4H-pyridin-1-yl)-1,4-dihydroquinoxaline-2,3-dione 在 sodium hydroxide 、 硫酸 、 potassium nitrate 作用下， 以 (2S)-N-methyl-1-phenylpropan-2-amine hydrate 为溶剂， 生成 6-nitro-7-(4-oxo-4H-pyridin-1-yl)-1,4-dihydroquinoxaline-2,3-dione
  参考文献：
  名称：

  Oxopyridinylquinoxaline derivative

  摘要：

  一种由以下化学式I表示的氧吡啶基喹喔啉衍生物或其药用盐：##STR1##其中R.sup.1为氢、卤素、硝基或三卤甲基；R.sup.2为氢、卤素、硝基、氰基、三卤甲基、氨基甲酰基、带有较低烷基取代的氨基甲酰基、磺胺基或带有较低烷基取代的磺胺基；R.sup.3为氢、硝基或卤素；R.sup.4为氢、较低烷基、取代的较低烷基、较低环烷基或取代的较低环烷基；R.sup.5'为从卤素、硝基、氰基、较低烷基、氨基甲酰基和带有较低烷基取代的氨基甲酰基组成的基团中独立选择的取代基；n为0到4的整数。该衍生物作为对NMDA受体和AMPA受体的拮抗剂，因此对由兴奋性氨基酸结合到受体引起的神经系统疾病具有治疗作用。

  公开号：

  US05677305A1

文献信息

• Oxopyridinylquinoxaline derivatives
  申请人：SHIONOGI & CO., LTD.

  公开号：EP0676397A1

  公开（公告）日：1995-10-11

  An oxopyridinylquinoxaline derivative represented by the following Formula I or pharmaceutically acceptable salts thereof: wherein R¹ is hydrogen, halogen, nitro, or trihalomethyl; R² is hydrogen, halogen, nitro, cyano, trihalomethyl, carbamoyl, carbamoyl substituted with lower alkyl, sulfamoyl, or sulfamoyl substituted with lower alkyl; R³ is hydrogen, nitro, or halogen; R⁴ is hydrogen, lower alkyl, substituted lower alkyl, lower cycloalkyl, or substituted lower cycloalkyl; R5's are substituents independently selected from the group consisting of halogen, nitro, cyano, lower alkyl, carbamoyl, and carbamoyl substituted with lower alkyl; and n is an integer of 0 to 4. The derivative works as an antagonistic agent against both the NMDA receptors and the AMPA receptors, so that it is effective as a therapeutic agent for neurological disorders caused by excitatory amino acids binding to the receptors.

  下式 I 所代表的氧吡啶基喹喔啉衍生物或其药学上可接受的盐类： 其中R¹是氢、卤素、硝基或三卤甲基；R²是氢、卤素、硝基、氰基、三卤甲基、氨基甲酰基、被低级烷基取代的氨基甲酰基、氨基磺酰基或被低级烷基取代的氨基磺酰基；R³是氢、硝基或卤素；R⁴ 是氢、低级烷基、取代的低级烷基、低级环烷基或取代的低级环烷基；R5 是独立选自卤素、硝基、氰基、低级烷基、氨基甲酰基和被低级烷基取代的氨基甲酰基组成的取代基；以及 n 是 0 至 4 的整数。该衍生物对 NMDA 受体和 AMPA 受体均有拮抗作用，因此可有效治疗由兴奋性氨基酸与受体结合引起的神经紊乱。
• GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE
  申请人：Morrell Craig Norman

  公开号：US20100196354A1

  公开（公告）日：2010-08-05

  The present invention relates to methods and compositions for modulating platelet activity by inhibiting or activating glutamate receptors. The invention further relates to preventing or treating thrombotic diseases.
• US5677305A
  申请人：——

  公开号：US5677305A

  公开（公告）日：1997-10-14
• [EN] GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE<br/>[FR] ANTAGONISTES DE RÉCEPTEUR DE GLUTAMATE ET PROCÉDÉS D'UTILISATION
  申请人：UNIV JOHNS HOPKINS

  公开号：WO2008088820A2

  公开（公告）日：2008-07-24

  [EN] The present invention relates to methods and compositions for modulating platelet activity by inhibiting or activating glutamate receptors. The invention further relates to preventing or treating thrombotic diseases.
  [FR] La présente invention concerne des procédés et des compositions pour moduler une activité de plaquette en inhibant ou en activant des récepteurs de glutamate. L'invention concerne en outre la prévention ou le traitement de maladies thrombotiques.
• Oxopyridinylquinoxaline derivative
  申请人：Shionogi & Co., Ltd.

  公开号：US05677305A1

  公开（公告）日：1997-10-14

  An oxopyridinylquinoxaline derivative represented by the following Formula I or pharmaceutically acceptable salts thereof: ##STR1## wherein R.sup.1 is hydrogen, halogen, nitro, or trihalomethyl; R.sup.2 is hydrogen, halogen, nitro, cyano, trihalomethyl, carbamoyl, carbamoyl substituted with lower alkyl, sulfamoyl, or sulfamoyl substituted with lower alkyl; R.sup.3 is hydrogen, nitro, or halogen; R.sup.4 is hydrogen, lower alkyl, substituted lower alkyl, lower cycloalkyl, or substituted lower cycloalkyl; R.sup.5 's are substituents independently selected from the group consisting of halogen, nitro, cyano, lower alkyl, carbamoyl, and carbamoyl substituted with lower alkyl; and n is an integer of 0 to 4. The derivative works as an antagonistic agent against both the NMDA receptors and the AMPA receptors, so that it is effective as a therapeutic agent for neurological disorders caused by excitatory amino acids binding to the receptors.

  一种由以下化学式I表示的氧吡啶基喹喔啉衍生物或其药用盐：##STR1##其中R.sup.1为氢、卤素、硝基或三卤甲基；R.sup.2为氢、卤素、硝基、氰基、三卤甲基、氨基甲酰基、带有较低烷基取代的氨基甲酰基、磺胺基或带有较低烷基取代的磺胺基；R.sup.3为氢、硝基或卤素；R.sup.4为氢、较低烷基、取代的较低烷基、较低环烷基或取代的较低环烷基；R.sup.5'为从卤素、硝基、氰基、较低烷基、氨基甲酰基和带有较低烷基取代的氨基甲酰基组成的基团中独立选择的取代基；n为0到4的整数。该衍生物作为对NMDA受体和AMPA受体的拮抗剂，因此对由兴奋性氨基酸结合到受体引起的神经系统疾病具有治疗作用。