Naphthalene-trisulphonic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Naphthalene-trisulphonic acid
• 英文别名: naphthalene-1,2,3-trisulfonic acid
• 化学式: C₁₀H₈O₉S₃
• 分子量: 368.4
• InChiKey: GPUMPJNVOBTUFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  188
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  1-氨基-8-萘酚-3,6-二磺酸 、 萘 、 水合硫酸 、 发烟硫酸 生成 Naphthalene-trisulphonic acid
  参考文献：
  名称：

  Process for the preparation of 1-amino-8-naphthol-3,6-disulphonic acid

  摘要：

  本发明涉及一种从萘胺三磺酸异构物混合物中通过高压碱性水解制备1-氨基-8-萘酚-3,6-二磺酸（H-酸）的单碱金属盐的过程。利用含有萘烷和/或硝基萘烷和/或萘胺和/或萘酚和/或氨基萘酚单磺酸、二磺酸和/或三磺酸的硫酸水溶液分离H-酸。

  公开号：

  US04325889A1

文献信息

• TUMOR TARGETED DRUG COMBRETASTATIN A4 DERIVATIVE
  申请人：Wang Yong

  公开号：US20140128384A1

  公开（公告）日：2014-05-08

  The present invention relates to imidazole, oxazole and thiazole derivatives of tumor-targeted drug combretastatin A4, and phosphate esters, sulfonate esters or pharmaceutically acceptable salts, glycoside derivatives, solvates thereof, wherein the A-ring comprises a 3,5-dimethoxyphenyl group having a substituent at the 4-position. The pharmacological activity assays have demonstrated that the compounds of the present invention have good in vitro anti-tumor activity and excellent tubulin inhibitory effect.

  本发明涉及肿瘤靶向药物康柏他丁A4的咪唑、噁唑和噻唑衍生物，以及磷酸酯、磺酸酯或药用可接受的盐、糖苷衍生物、其溶剂合物，其中A环包括在4位有取代基的3,5-二甲氧基苯基基团。药理活性测定表明，本发明的化合物在体外具有良好的抗肿瘤活性和优秀的微管抑制作用。
• [EN] PROCESS FOR MAKING BUTENYL ESTERS FROM BUTADIENE<br/>[FR] PROCEDE DE FABRICATION D'ESTERS A PARTIR DE BUTADIENE
  申请人：BP CHEM INT LTD

  公开号：WO2003082796A1

  公开（公告）日：2003-10-09

  A process for making a butenyl ester from butadiene by reacting butadiene or a hydrocarbon fraction containing butadiene with a saturated aliphatic monocarboxylic acid, wherein the catalyst is rhenium (VII) oxide or an organic sulphonic acid containing at least (2) sulphonic acid groups per molecule wherein the ratio of the number of carbon atoms to the number of sulphonic acid groups in the organic sulphonic acid is in the range 1 : 1 to 1 : 0.15. Preferred catalysts are organic disulphonic acids for example ethane-1,2-disulphonic acid. The process can be used for making unsaturated esters, or, by hydrogenation of the product, for making saturated esters such as for example butyl acetate. Catalyst can be purified and recycled to the reactor.

  一种从丁二烯中制备丁烯酸酯的方法，包括将丁二烯或含有丁二烯的碳氢化合物与饱和脂肪族一元羧酸反应，其中催化剂为铼（VII）氧化物或含有每个分子至少（2）磺酸基团的有机磺酸，有机磺酸中碳原子数与磺酸基团数的比值在1：1至1：0.15范围内。优选的催化剂是有机二磺酸，例如乙烷-1,2-二磺酸。该方法可用于制备不饱和酯，或通过产物的加氢，用于制备饱和酯，例如醋酸丁酯。催化剂可以被净化并回收到反应器中。
• Polycarbonate resin compositon and molded article
  申请人：Mitsuhashi Kenichi

  公开号：US20050261414A1

  公开（公告）日：2005-11-24

  Provided are a polycarbonate resin composition which does not contain halogen and phosphorus as a flame retardant component and which is excellent in a fluidity while maintaining a flame resistance, a heat resistance and an impact resistance and a molded article thereof. The polycarbonate resin composition comprises (A) 60 to 97 mass % of an aromatic polycarbonate resin composition and 3 to 40 mass % of (B) an acrylonitrile-styrene base resin having a melt flow rate (MFR) of 5 or more at 200° C. and a load of 5 kg, wherein it is blended with 0 to 37 mass parts of (C) an impact resistance-improving agent, 0 to 3 mass parts of (D) an organic alkali metal salt and/or an organic alkali earth metal salt, 0 to 3 mass parts of (E) a functional group-containing silicone compound, 0 to 55 mass parts of (F) an inorganic filler and 0 to 2 mass parts of (G) a polyfluoroolefin resin each per total 100 mass parts of (A) and (B).

  提供一种聚碳酸酯树脂组合物，不含卤素和磷作为阻燃组分，同时保持耐火性、耐热性和抗冲击性，以及其模制品。该聚碳酸酯树脂组合物包括(A) 60-97质量％的芳香族聚碳酸酯组合物和3-40质量％的(B) 丙烯腈-苯乙烯基树脂，其在200℃和5千克的负荷下具有熔融流动速率（MFR）为5或更高。其中，它与(C) 抗冲击性改进剂的0-37质量部分混合，以及每100质量部分(A)和(B)中的0-3质量部分(D) 有机碱金属盐和/或有机碱土金属盐，0-3质量部分(E) 含有功能基团的硅氧烷化合物，0-55质量部分(F) 无机填料和0-2质量部分(G) 聚氟烯烃树脂。
• POLYCARBONATE RESIN COMPOSITION AND MOLDED ARTICLE
  申请人：MITSUHASHI Kenichi

  公开号：US20080076866A1

  公开（公告）日：2008-03-27

  Provided are a polycarbonate resin composition which does not contain halogen and phosphorus as a flame retardant component and which is excellent in a fluidity while maintaining a flame resistance, a heat resistance and an impact resistance and a molded article thereof.

  提供了一种聚碳酸酯树脂组合物，该组合物不含卤素和磷作为阻燃组分，同时具有出色的流动性能，同时保持着耐火性、耐热性和抗冲击性，以及其成型品。
• Polycarbonate resin composition and molded article thereof
  申请人：Isozaki Toshio

  公开号：US20070179233A1

  公开（公告）日：2007-08-02

  A polycarbonate resin composition, which exhibits not only an excellent balance among fluidity, rigidity, heat resistance, and impact resistance while maintaining flame retardance but also an excellent performance of recycling efficiency and a molded article thereof are provided. The polycarbonate resin composition contains a resin mixture of component (A) which is composed of (A-1) 10 to 100 mass % of an aromatic polycarbonate resin wherein dihydroxybiphenyl is used in a part of a divalent phenol as the raw material thereof and (A-2) 90 to 0 mass % of an aromatic polycarbonate resin other than the aromatic polycarbonate resin of component (A-1), and an amorphous styrene resin (B), in a mass ratio of component (A) to component (B) of 50:50 to 95:5. The molded article is an injection-molded article made of the polycarbonate resin composition.

  提供了一种聚碳酸酯树脂组合物，它不仅在保持阻燃性的同时展现了流动性、刚度、耐热性和抗冲击性之间的优异平衡，而且具有出色的回收效率表现和由该聚碳酸酯树脂组合物制成的成型品。该聚碳酸酯树脂组合物包含组分(A)的树脂混合物，其中组分(A)由(A-1)芳香族聚碳酸酯树脂组成，其中二羟基联苯在部分二价酚原料中使用，并且(A-2)为除组分(A-1)芳香族聚碳酸酯树脂之外的芳香族聚碳酸酯树脂，以及非晶态苯乙烯树脂(B)，组分(A)与组分(B)的质量比为50:50至95:5。成型品是由该聚碳酸酯树脂组合物制成的注塑成型品。