Dexamethasone-tobramycin mixt. | 288392-57-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Dexamethasone-tobramycin mixt.
• 英文别名: (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol;(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
• CAS: 288392-57-4
• 化学式: C40H66FN5O14
• 分子量: 860.0
• InChiKey: DWLNMMCXGSKYEM-VQHMUFKESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.4
• 重原子数：
  60
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  363
• 氢给体数：
  13
• 氢受体数：
  20

文献信息

• Medical device for treatment of a sinus and/or an ear and methods of use thereof
  申请人：SINUSAFE MEDICAL LTD.

  公开号：US11083484B2

  公开（公告）日：2021-08-10

  There is provided herein, a device for treating and/or diagnosing a sinus or an ear condition, the device comprising a housing comprising or functionally connected to: a hollow cannula defining a lumen extending at least partially along the length thereof, the cannula is configured to be at least partially inserted through an ostium into a sinus cavity/ear of a subject; and a flexible grinding wire movable within the cannula's lumen and configured to be inserted into and retrieved out of the sinus cavity through the cannula's lumen, and to rotate along a longitudinal axis thereof and thereby grind, chop and/or stir material present in the sinus cavity and/or inside the hollow cannula, wherein the cannula is in fluid flow communication with an irrigation/aspiration source; and a wire handle functionally connected to the wire, allowing a user to advance and retrieve the wire within the cannula and into and out of the cannula lumen, wherein the device is handheld by a gripping handle.

  本文提供了一种用于治疗和/或诊断鼻窦或耳部疾病的装置，该装置包括一个壳体，该壳体由以下部分组成或在功能上与以下部分相连接：一个中空套管，该套管限定了一个至少部分沿其长度方向延伸的管腔，该套管被配置为至少部分通过骨膜插入受试者的窦腔/耳内；可在套管管腔内移动的柔性研磨丝，可通过套管管腔插入窦腔和从窦腔取出，并可沿其纵轴旋转，从而研磨、切碎和/或搅拌存在于窦腔和/或空心套管内的材料，其中套管与灌注/抽吸源进行流体流动通信；与金属丝功能性连接的金属丝手柄，允许用户在套管内推进和收回金属丝，并将金属丝放入和取出套管腔，其中，该装置通过抓握手柄手持。
• Compositions and methods for treating Leber's hereditary optic neuropathy
  申请人：WUHAN NEUROPHTH BIOTECHNOLOGY LIMITED COMPANY

  公开号：US11352645B2

  公开（公告）日：2022-06-07

  Disclosed herein is a recombinant nucleic acid, comprising: a mitochondrial targeting sequence; a mitochondrial protein coding sequence, wherein said mitochondrial protein coding sequence encodes a polypeptide comprising a mitochondrial protein; and a 3′UTR nucleic acid sequence. Also disclosed is a pharmaceutical composition comprising the recombinant nucleic acid and a method of treating Leber's hereditary optic neuropathy (LHON) using the pharmaceutical composition.

  本文公开了一种重组核酸，包括：线粒体靶向序列；线粒体蛋白编码序列，其中所述线粒体蛋白编码序列编码包含线粒体蛋白的多肽；以及3′UTR核酸序列。还公开了一种包含重组核酸的药物组合物和一种使用该药物组合物治疗勒伯遗传性视神经病变（LHON）的方法。
• MEDICAL DEVICE FOR TREATMENT OF A SINUS AND/OR AN EAR AND METHODS OF USE THEREOF
  申请人：Sinusafe Medical Ltd

  公开号：EP3478356A1

  公开（公告）日：2019-05-08
• METHODS AND COMPOSITIONS FOR ASSESSING AND TREATING INTRAOCULAR DISEASES AND DISORDERS
  申请人：Zhuhai Qiwei Bio-technology Ltd.

  公开号：EP3701048A1

  公开（公告）日：2020-09-02
• COMPOSITIONS AND METHODS FOR TREATING LEBER'S HEREDITARY OPTIC NEUROPATHY
  申请人：Wuhan Neurophth Biotechnology Limited Company

  公开号：EP3840785A1

  公开（公告）日：2021-06-30