3-(m,m-dibromo-p-hydroxyphenyl)-D,L-lactic acid | 875245-03-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-(m,m-dibromo-p-hydroxyphenyl)-D,L-lactic acid
• 英文别名: 3-(3,5-dibromo-4-hydroxy-phenyl)-2-hydroxy-propionic acid；3-(3,5-Dibrom-4-hydroxy-phenyl)-2-hydroxy-propionsaeure；3-(3,5-Dibromo-4-hydroxyphenyl)-2-hydroxypropanoic acid
• CAS: 875245-03-7
• 化学式: C₉H₈Br₂O₄
• 分子量: 339.968
• InChiKey: KXOPOMFBWDCGJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  DL-4-羟基苯乳酸 在 溴 、 溶剂黄146 作用下， 生成 3-(m,m-dibromo-p-hydroxyphenyl)-D,L-lactic acid
  参考文献：
  名称：

  Habild, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1950, vol. 285, p. 127,135

  摘要：

  DOI：

文献信息

• New CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
  申请人：Mueller Georg Stephan

  公开号：US20060252931A1

  公开（公告）日：2006-11-09

  The present invention relates to the CGRP-antagonists of general formula I wherein R 1 , R 2 , R 3 , R 4 and X are defined as in claim 1 , the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates, mixtures and salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, as well as those compounds of general formula I in which one or more hydrogen atoms are replaced by deuterium, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.

  本发明涉及一般式I的CGRP拮抗剂，其中R1、R2、R3、R4和X如权利要求1中所定义，其互变异构体、异构体、对映异构体、立体异构体、水合物、混合物和盐以及该盐的水合物，特别是与无机或有机酸或碱的生理可接受盐，以及其中一个或多个氢原子被氘取代的一般式I化合物，含有这些化合物的药物组合物，其使用和制备过程。
• Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
  申请人：Mueller Georg Stephan

  公开号：US20060252750A1

  公开（公告）日：2006-11-09

  The present invention relates to the CGRP antagonists of general formula wherein A, X, D, E, G, M, Q and R 1 to R 3 are defined as in claim 1, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.

  本发明涉及一般式为的CGRP拮抗剂，其中A、X、D、E、G、M、Q和R1至R3如权利要求1所定义，其互变异构体、异构体、对映异构体、对映体、水合物、混合物及其盐和盐的水合物，特别是与无机或有机酸形成的生理上可接受的盐及其盐的水合物，以及含有这些化合物的药物组合物，其用途和制备过程。
• SELECTED CGRP-ANTAGONISTS, PROCESS FOR PREPARING THEM AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
  申请人：MUELLER Stephan Georg

  公开号：US20100234361A1

  公开（公告）日：2010-09-16

  The present invention relates to the CGRP antagonists of general formula wherein A, X, D, E, G, M, Q and R 1 to R 3 are defined as in claim 1, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.

  本发明涉及一般式为的CGRP拮抗剂其中A，X，D，E，G，M，Q和R1至R3如权利要求1中所定义，其互变异构体，异构体，对映异构体，对映体，水合物，其混合物和其盐以及盐的水合物，特别是其与无机或有机酸的生理上可接受的盐，含有这些化合物的制药组合物，其用途以及其制备方法。
• CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
  申请人：MUELLER Stephan Georg

  公开号：US20090186881A1

  公开（公告）日：2009-07-23

  The present invention relates to the CGRP-antagonists of general formula I wherein R 1 , R 2 , R 3 , R 4 and X are defined as in claim 1 , the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates, mixtures and salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, as well as those compounds of general formula I in which one or more hydrogen atoms are replaced by deuterium, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.

  本发明涉及一般式I的CGRP拮抗剂，其中R1、R2、R3、R4和X的定义如权利要求书中所述，其互变异构体、异构体、对映体、单对映体、水合物、混合物和盐以及盐的水合物，特别是与无机或有机酸或碱的生理上可接受的盐，以及一种或多种氢原子被氘代替的一般式I的化合物，包括这些化合物的制药组合物、使用方法和制备方法。
• Spatial structure and variability of fields of currents, attenuation factor of light, and temperature in the surface layer of the northwest part of the Black Sea
  作者：E. A. Agafonov、S. T. Kaminsky、A. S. Kukushkin、Yu. A. Prokhorenko

  DOI：10.1007/bf02519306

  日期：2000.7