2-amino-hexane-1,6-diol | 98961-85-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-amino-hexane-1,6-diol
• 英文别名: 2-Amino-hexan-1,6-diol；2-Aminohexane-1,6-diol
• CAS: 98961-85-4
• 化学式: C₆H₁₅NO₂
• mdl: MFCD19206216
• 分子量: 133.191
• InChiKey: GBNLFZXEMQBLJZ-UHFFFAOYSA-N

物化性质

• 沸点：
  135-145 °C(Press: 0.4 Torr)
• 密度：
  1.051±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-amino-hexane-1,6-diol 在 盐酸 、 乙醇 、 氯仿 、 三氯氧磷 作用下， 生成 (5-chloro-1-chloromethyl-pentyl)-(2-chloro-ethyl)-phosphoramidic acid dichloride
  参考文献：
  名称：

  New Nitrogen Mustards for “Toxagenic” Anti-cancer Agents^1a,b

  摘要：

  DOI：

  10.1021/ja01599a036
• 作为产物：
  描述：

  2-溴己二酸二乙酯 在 lithium aluminium tetrahydride 、 乙醚 、 乙醇 、 sodium nitrite 作用下， 生成 2-amino-hexane-1,6-diol
  参考文献：
  名称：

  The irradiation history of the Ghubara (L5) regolith breccia

  摘要：

  Abstract— We measured cosmic‐ray products—noble gases, radionuclides, thermoluminescence, and nuclear tracks—and trace element contents and mineralogy of samples of three orthogonal and mutually intersecting cores (41–46 cm long) of a 101.6 kg Ghubara individual (1958,805) at The Natural History Museum, London. The xenoliths, like the host, have high concentrations of trapped solar gases and are heavily shocked. While contents of noble gases and degree of shock‐loading in this individual and three others differ somewhat, the data indicate that Ghubara is a two‐generation regolith breccia. Contents of cosmogenic 26Al and 10Be and low track densities indicate that the Ghubara individuals were located more than 15 cm below the surface of an 85 cm meteoroid. Because of its large size, Ghubara's cosmic‐ray exposure age is poorly defined to be 15–20 Ma from cosmogenic nuclides. Ghubara's terrestrial age, based on 14C data, is 2–3 ka. Not only is Ghubara the first known case of a two‐generation regolith breccia on the macroscale, it also has a complicated thermal and irradiation history.

  DOI：

  10.1111/j.1945-5100.2002.tb00819.x

文献信息

• [EN] 3-OXO-2,6-DIPHENYL-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES<br/>[FR] 3-OXO-2,6-DIPHÉNYL-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES
  申请人：BAYER PHARMA AG

  公开号：WO2017202816A1

  公开（公告）日：2017-11-30

  The present invention covers 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.

  本发明涵盖了一般式(I)的3-氧代-2,6-二苯基-2,3-二氢吡啶嗪-4-羧酰胺化合物：其中R1、R2、R3、R4、R5和R6如本文所定义，制备所述化合物的方法，用于制备所述化合物的有用中间体化合物，包括所述化合物的药物组合物和组合物，以及利用所述化合物制造用于治疗或预防疾病的药物组合物，特别是癌症或与异常AHR信号传导相关的疾病，或与10种不规则免疫反应或其他与异常AHR信号传导相关的疾病的情况，作为单一药剂或与其他活性成分结合使用。
• BIOLOGICAL SYNTHESIS OF DIFUNCTIONAL HEXANES AND PENTANES FROM CARBOHYDRATE FEEDSTOCKS
  申请人：Celexion, LLC

  公开号：US20140212934A1

  公开（公告）日：2014-07-31

  Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.

  本文提供了一种在微生物中生产双官能基烷烃的方法。还提供了编码这种酶的酶和核酸，与微生物中从碳水化合物饲料中生产双官能基烷烃相关。本发明还提供了重组微生物和代谢途径，用于生产双官能基烷烃。
• ETHYLENICALLY UNSATURATED GROUP-CONTAINING ISOCYANATE COMPOUND AND PROCESS FOR PRODUCING THE SAME, AND REACTIVE MONOMER, REACTIVE (METH)ACRYLATE POLYMER AND ITS USE
  申请人：SHOWA DENKO K.K.

  公开号：EP1812381B1

  公开（公告）日：2011-02-16
• 3-OXO-2,6-DIPHENYL-2,3-DIHYDROPYRIDAZINE-4-CARBOXAMIDES
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：EP3464248A1

  公开（公告）日：2019-04-10
• Ethylenically Unsaturated Group-Containing Isocyanate Compound and Process for Producing the Same, and Reactive Monomer, Reactive (Meth) Acrylate Polymer and its Use
  申请人：Nozawa Kaneo

  公开号：US20080132597A1

  公开（公告）日：2008-06-05

  There are provided a novel ethylenically unsaturated group-containing isocyanate compound, a process for producing the same, and a reactive monomer produced from the isocyanate compound, a reactive polymer and its use. The ethylenically unsaturated group-containing isocyanate compound according to the present invention is represented by formula (I).