(1R,2R)-N1-cyclohexylcyclohexane-1,2-diamine | 1204751-24-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1R,2R)-N1-cyclohexylcyclohexane-1,2-diamine
• 英文别名: (1R,2R)-2-N-cyclohexylcyclohexane-1,2-diamine
• CAS: 1204751-24-5
• 化学式: C₁₂H₂₄N₂
• 分子量: 196.336
• InChiKey: WPHMAFXLKAGEKZ-VXGBXAGGSA-N

物化性质

• 沸点：
  280.6±8.0 °C(Predicted)
• 密度：
  0.96±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1R,2R)-N1-cyclohexylcyclohexane-1,2-diamine 以 水 为溶剂， 反应 30.0h， 生成
  参考文献：
  名称：

  Synthesis and biological evaluation of platinum(II) complexes containing (1R,2R)-N1-alkyl-1,2-diaminocyclohexane and D-(+)-camphorate ligands

  摘要：

  Five platinum(II) complexes with N-monoalkyl derivatives of 1R,2R-diaminocyclohexane as ligands and D-(+)-camphorate anion as leaving group have been synthesized and characterized by elemental analysis, IR, H-1 NMR, ESI-MS, and HRMS spectra. All complexes were evaluated for their in vitro cytotoxicity against four human tumor cell lines and most of them showed promising cytotoxic activity, especially compounds 3 and 4 with branched alkyl substituent at one of nitrogen atoms. Preliminary mechanism study by flow cytometry and agarose gel electrophoresis was also carried out in comparison with cisplatin and oxaliplatin. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.10.011
• 作为产物：
  描述：

  在 盐酸 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 10.0h， 以2.29 g的产率得到(1R,2R)-N1-cyclohexylcyclohexane-1,2-diamine
  参考文献：
  名称：

  Enamine-Iminium Ion Nazarov Cyclization of α-Ketoenones

  摘要：

  The mono-triflate salts of some chiral nonracemic 1,2-diamines react with alpha-ketoenones in a stoichiometric reaction to form products of the Nazarov cyclization in high enantiomeric ratios. The mechanism appears to involve rearrangement of an enamine-iminium ion.

  DOI：

  10.1021/ol9025765
• 作为试剂：
  描述：

  4-Methyl-5-phenylpent-4-ene-2,3-dione 在 (1R,2R)-N1-cyclohexylcyclohexane-1,2-diamine 作用下， 生成 (S)-2-hydroxy-3-methyl-4-phenyl-cyclopent-2-enone 、 (R)-2-hydroxy-3-methyl-4-phenyl-cyclopent-2-enone
  参考文献：
  名称：

  Enamine-Iminium Ion Nazarov Cyclization of α-Ketoenones

  摘要：

  The mono-triflate salts of some chiral nonracemic 1,2-diamines react with alpha-ketoenones in a stoichiometric reaction to form products of the Nazarov cyclization in high enantiomeric ratios. The mechanism appears to involve rearrangement of an enamine-iminium ion.

  DOI：

  10.1021/ol9025765