Leu(OH)P | 119012-04-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: Leu(OH)P
• 英文别名: (+/-)-(1-Hydroxy-3-methylbutyl)phosphonic acid；1-hydroxy-3-methylbutanephosphonic acid；(1-hydroxy-3-methyl-butyl)-phosphonic acid；(1-Hydroxy-3-methyl-butyl)-phosphonsaeure；(α-Hydroxyisopentyl)-phosphonsaeure；α-Oxyisoamyl-phosphinsaeure；Phosphonic acid, (1-hydroxy-3-methylbutyl)-；(1-hydroxy-3-methylbutyl)phosphonic acid
• CAS: 119012-04-3
• 化学式: C₅H₁₃O₄P
• mdl: MFCD30335726
• 分子量: 168.13
• InChiKey: AIJCQEYSBDDMHQ-UHFFFAOYSA-N

物化性质

• 沸点：
  331.1±44.0 °C(Predicted)
• 密度：
  1.308±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Leu(OH)P 、 氢碘酸 生成 Isoamyl phosphonate
  参考文献：
  名称：

  Marie, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1903, vol. 136, p. 48

  摘要：

  DOI：
• 作为产物：
  描述：

  异戊醛 在 亚磷酸 作用下， 生成 Leu(OH)P
  参考文献：
  名称：

  Marie, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1903, vol. 136, p. 48

  摘要：

  DOI：

文献信息

• A Simple, Efficient Synthesis of Dibenzyl and Di-<i>p</i>-nitrobenzyl 1-Hydroxyalkanephosphonates
  作者：Maria Hoffmann

  DOI：10.1055/s-1988-33434

  日期：——

  Dibenzyl and di-p-nitrobenzyl 1-hydroxyalkanephosphonates 3a-i are prepared by alkylation of 1-hydroxyalkanephosphonic acids 1 with O-benzyl and O-(p-nitrobenzyl)-N,N′-dicyclohexylisoureas 2.

  二苯基和二对硝基苯基1-羟基烷基磷酸酯3a-i是通过将1-羟基烷基磷酸一酸1与O-苄基和O-(对硝基苯基)-N,N′-二环己基异脲2进行烷基化反应制备的。
• Deamination of 1-Aminoalkylphosphonic Acids: Reaction Intermediates and Selectivity
  作者：Anna Brol、Tomasz K. Olszewski

  DOI：10.3390/molecules27248849

  日期：——

  acids in the reaction with HNO2 (generated "in situ" from NaNO2) yields a mixture of substitution products (1-hydroxyalkylphosphonic acids), elimination products (vinylphosphonic acid derivatives), rearrangement and substitution products (2-hydroxylkylphosphonic acids) as well as H3PO4. The variety of formed reaction products suggests that 1-phosphonoalkylium ions may be intermediates in such deamination

  1-氨基烷基膦酸在与 HNO2 的反应中脱氨（从 NaNO2“原位”生成）产生取代产物（1-羟基烷基膦酸）、消除产物（乙烯基膦酸衍生物）、重排和取代产物（2-羟基烷基膦酸）的混合物) 以及 H3PO4。形成的各种反应产物表明 1-phosphonoalkylium 离子可能是此类脱氨反应的中间体。
• Reactions of Chiral Phosphorous Acid Diamides: The Asymmetric Synthesis of Chiral .alpha.-Hydroxy Phosphonamides, Phosphonates, and Phosphonic Acids
  作者：Vincent J. Blazis、Kevin J. Koeller、Christopher D. Spilling

  DOI：10.1021/jo00109a025

  日期：1995.2

  Addition of aldehydes to the anions of chiral phosphorous acid diamides in THF solution gave a-hydroxy phosphonamides in good yield. The diastereoselectivity was strongly dependent upon the diamide used and ranged from poor to good. The phosphorous acid diamides 2a and 2b (R(1) = -(CH2)4-,R(2) = CH(2)Ph and CH(2)CMe(3), respectively) gave the best selectivity, and their reactions with a range of aldehydes were studied. Diamide 2b consistently gave good selectivities, whereas diamide 2a was only moderately selective. Aromatic, aliphatic, and unsaturated aldehydes are tolerated under the reaction conditions. The phosphonamides were hydrolyzed with aqueous HCl in dioxane to give a-hydroxy phosphonic acids. While direct methanolysis of the phosphonamides was unsuccessful, methylation of the phosphonic acids with diazomethane gave alpha-hydroxy dimethylphosphonates.
• Kuskow et al., Doklady Akademii Nauk SSSR, 1958, vol. 120, p. 786
  作者：Kuskow et al.

  DOI：——

  日期：——
• Hoffmann, Maria, Polish Journal of Chemistry, 1982, vol. 56, # 7/8/9, p. 1191 - 1194
  作者：Hoffmann, Maria

  DOI：——

  日期：——