雄器素 | 22263-79-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 雄器素
• 英文名称: Antheridiol
• 英文别名: (2R)-2-[(1S,2S)-1-hydroxy-2-[(3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-7-oxo-1,2,3,4,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]propyl]-3-propan-2-yl-2H-furan-5-one
• CAS: 22263-79-2
• 化学式: C₂₉H₄₂O₅
• 分子量: 470.6
• InChiKey: CJKCBJGFGMXLOO-VYTMURAFSA-N

物化性质

• 熔点：
  250-255°

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Polypeptide that interacts with heat shock proteins
  申请人：Board of Regents, The University of Texas System

  公开号：US20020177212A1

  公开（公告）日：2002-11-28

  An isolated polypeptide having negative regulating activity for a heat shock protein is provided. Also provided is an isolated nucleic acid encoding the polypeptide of the invention, methods for identifying inhibitors of the polypeptide and recombinant preparation of the polypeptide. Also provided are compositions such as inhibitor compositions.

  本发明提供了一种具有热休克蛋白负调控活性的分离多肽。还提供了编码本发明多肽的分离核酸、鉴定本发明多肽抑制剂的方法以及本发明多肽的重组制备方法。还提供了抑制剂组合物等组合物。
• Nucleic acid amplification with direct sequencing
  申请人：——

  公开号：US20030143553A1

  公开（公告）日：2003-07-31

  This invention provides methods of amplifying a sequence of interest present within a nucleic acid molecule. In addition, this invention provides a method of determining the nucleotide sequence of a sequence of interest present within a nucleic acid molecule (e.g. GAWTS and RAWTS) which can be used to sequence tissue specific genes (e.g. tsRAWTS) and genes accross species (e.g. zooRAWTS). In addition, this invention provides a method of synthesizing a polypeptide encoded for by a nucleic acid molecule (RAWIT). Further, the subject invention provides a method of determining an internal nucleotide sequence present within a nucleic acid molecule, and a method of determining a terminal nucleotide sequence present within a nucleic acid molecule (e.g. PLATS). Also provided for is a method of determining the nucleotide sequence of sequences present within a nucleic acid molecule which are adjacent to areas of known sequence (e.g ASWATS) and a method of determining the nucleotide sequence of sequences present within a nucleic acid molecule and a method of detecting point mutation or polymorphism (e.g. PASA) which can be used in low cost methods of carrier testing and prenatal diagnosis. Lastly, this invention provides methods for determining the exonic nucleotide sequence of a gene as well as methods of detecting genomic mutations.

  本发明提供了扩增核酸分子中存在的感兴趣序列的方法。此外，本发明还提供了一种确定核酸分子（如 GAWTS 和 RAWTS）中存在的感兴趣序列的核苷酸序列的方法，该方法可用于组织特异性基因（如 TSRAWTS）和跨物种基因（如 zooRAWTS）的测序。 此外，本发明还提供了一种合成由核酸分子（RAWIT）编码的多肽的方法。此外，本发明还提供了一种确定核酸分子内部核苷酸序列的方法，以及一种确定核酸分子末端核苷酸序列的方法（如 PLATS）。 本发明还提供了一种确定核酸分子内存在的与已知序列区域相邻的序列的核苷酸序列的方法（如 ASWATS），以及一种确定核酸分子内存在的序列的核苷酸序列的方法和一种检测点突变或多态性的方法（如 PASA），这些方法可用于低成本的携带者检测和产前诊断方法。 最后，本发明提供了确定基因外显子核苷酸序列的方法以及检测基因组突变的方法。
• HUMAN CANCER ASSOCIATED GENE SEQUENCES AND POLYPEPTIDES
  申请人：HUMAN GENOME SCIENCES, INC.

  公开号：EP1163358A1

  公开（公告）日：2001-12-19
• USE OF A STEROID FOR ENHANCEMENT OF SKIN PERMEABILITY
  申请人：Novartis AG

  公开号：EP1773336A1

  公开（公告）日：2007-04-18
• Compounds exhibiting efflux inhibitor activity and composition and uses thereof
  申请人：Wempe Fitzpatrick Michael

  公开号：US20070254859A1

  公开（公告）日：2007-11-01

  At least one compound chosen from compounds of Formula I: a pharmaceutically acceptable salt or ester thereof, a solvate thereof, a chelate thereof, a non-covalent complex thereof, a prodrug thereof, and mixtures of any of the foregoing, wherein: n is a number from 1 to 900, wherein the individual units may be the same or different; W is chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; each of R 2 , R 3 , R 4 and R 5 is independently chosen from —H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; Z′ is chosen from —O—, —N—, —NO—, —NR 4 —, —S—, —SO— and —SO 2 —, wherein R 4 is defined as above; each of X, X′, Y and Z is independently chosen from —CR 4 R 5 —, —NH—, —NR 4 —, —NO—, —O—, —NOR 4 —, —S—, —SO—, —SO 2 —, wherein R 4 and R 5 are defined as above; R 1 is chosen from a tocopherol, a steroid and a flavonoid; and R 6 is chosen from any R 1 , alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl.