Pyrrolo[1,2-a]pyrimidine, octahydro-1-(phenylmethyl)- | 515145-31-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并嘧啶类
• 英文名称: Pyrrolo[1,2-a]pyrimidine, octahydro-1-(phenylmethyl)-
• 英文别名: 1-benzyl-3,4,6,7,8,8a-hexahydro-2H-pyrrolo[1,2-a]pyrimidine
• CAS: 515145-31-0
• 化学式: C₁₄H₂₀N₂
• 分子量: 216.32
• InChiKey: HYQWHUCTTYCIAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• MULTI-STEP PROCESS FOR NO PRODUCTION
  申请人：BSN medical GmbH

  公开号：US20180116920A1

  公开（公告）日：2018-05-03

  The present invention relates to a multi-step process for the production of nitrogen monoxide (NO) from a pH-labile NO donor in the presence of at least one antioxidant. The invention also relates to a device for implementation of said process and the use of said device for the treatment of diseases. Moreover, the invention relates to a cosmetic process using said process or said device.

  本发明涉及一种多步骤过程，用于在存在至少一种抗氧化剂的情况下，从pH不稳定的NO供体中生产一氧化氮（NO）。该发明还涉及用于实施该过程的装置以及利用该装置用于治疗疾病的方法。此外，该发明还涉及使用该过程或该装置的化妆过程。
• Photoactivable nitrogen bases
  申请人：——

  公开号：US20040242867A1

  公开（公告）日：2004-12-02

  Compounds of the formula I R7″N—R6 RS—C,N—R4 H C, R′/I R, 3 R 2 (I) in which R, is an aromatic or heteroaromatic radical which is capable of absorbing light in the wave-length range from 200 nm to 650 nm and which is unsubstituted or substituted one or more times by C,—C,8alkyl, C2-C,ealkenyl, C2-C,8alkynyl, C,—C,ehaloalkyl, NO2, NR,OR, CN, OR,2, SR,2, C(O)R,3, C(O)OR,4, halogen or a radical of the formula II R˜—N′ R6 1 R5-C,N.R4 H I C—R3 I R2 (E) and which on absorption brings about a photoelimination which leads to the generation of an amidine group, R2 and R3 independently of one another are hydrogen, C,—C,ealkyl or phenyl which is unsubstituted or is substituted one or more times by C,—C,8alkyl, CN, OR,2, SR,2, halogen or C,—C,ehaloalkyl; R5 is C,—C,ealkyl or NR8R9; R4, R6, R, R8, R9, R,o and R inde-pendently of one another are hydrogen or C,—C,8alkyl; or R4 and R6 together form a C2-C,2alkylene bridge which is unsubstituted or is substituted by one or more C1-C4alkyl radicals; or R5 and R, independently of R4 and R6, together form a C2-C,2alkylene bridge which is unsubstituted or is substituted by one or more C1-C4alkyl radicals; or, if R5 is a radi-cal NR8R9, R, and R9 together form a C2-C,2alkylene bridge which is unsubstituted or is substituted by one or more C1-C4alkyl radicals; and R,2, R,3 and R,4 independently of one another are hydrogen or C,—C,ealkyl; are suitable as photoinitiators for compounds which react under base catalysis. 1

  公式I中的化合物，其中R，是一种芳香或杂芳基团，能够在200nm至650nm的波长范围内吸收光，并且未被取代或被C,-C,8烷基，C2-C,e烯基，C2-C,8炔基，C,-C,卤代烷基，NO2，NR，OR，CN，OR,2，SR,2，C(O)R,3，C(O)OR,4，卤素或公式II R' -N' R6 1 R5-C，N.R4 H I C-R3 I R2（E）取代一次或多次，吸收后引起光消除，导致产生酰胺基团，其中R2和R3独立地是氢，C,-C,e烷基或苯基，未被取代或被C,-C,8烷基，CN，OR,2，SR,2，卤素或C,-C,卤代烷基取代；R5是C,-C,e烷基或NR8R9；R4，R6，R，R8，R9，R,o和R独立地是氢或C,-C,8烷基；或R4和R6共同形成一个未被取代或被一个或多个C1-C4烷基基团取代的C2-C,2烷基桥；或R5和R，独立于R4和R6，共同形成一个未被取代或被一个或多个C1-C4烷基基团取代的C2-C,2烷基桥；或者，如果R5是一个基团NR8R9，R，和R9共同形成一个未被取代或被一个或多个C1-C4烷基基团取代的C2-C,2烷基桥；而R,2，R,3和R,4独立地是氢或C,-C,e烷基；适用于在碱催化下反应的化合物的光引发剂。
• Letter with continuation application
  申请人：Baudin Gisele

  公开号：US20090076200A1

  公开（公告）日：2009-03-19

  Base-polymerizable or base-crosslinkable compositions comprising select bicyclic amines with benzylic substitution undergo photochemically induced, base-catalysed reactions upon photochemical conversion of the benzylically substituted amine to an amidine derivative.

  含有选择的苯基取代双环胺的基团可聚合或交联的组合物，在苯基取代胺光化学转化为酰胺衍生物时，经光化学诱导和碱催化反应。
• PHOTOACTIVABLE NITROGEN BASES
  申请人：Dietliker Kurt

  公开号：US20100105794A1

  公开（公告）日：2010-04-29

  Compounds of the Formula (I), (II) and (III) wherein Ar is for example phenylene, biphenylene or naphthylene, all of which are unsubstituted or substituted by C 1 -C 4 -alkyl, C 2 -C 4 -alkenyl, CN, OR 11 , SR 11 , CH2OR 11 , COOR 12 , CONR 12 R 13 or halogen; R 1 , R 2 , R 7 and R 8 independently of one another other are hydrogen or C 1 -C 6 -alkyl; R 3 and R 5 together and R 4 and R 6 together form a C 2 -C 6 -alkylene bridge which is unsubstituted or substituted by one or more C 1 -C 4 -alkyl; R 11 is hydrogen or C 1 -C 6 -alkyl; R 12 and R 13 independently of one another for example are hydrogen, phenyl, C 1 -C 18 -alkyl, C 1 -C 18 -alkyl which is interrupted by one or more O; n is 1-10; X is O, S or NR 10 ; A and A 1 are suitable linking groups; are suitable as photolatent bases.

  公式(I)、(II)和(III)的化合物，其中Ar可以是苯基、联苯基或萘基，它们都可以是未取代或被C1-C4烷基、C2-C4烯基、CN、OR11、SR11、CH2OR11、COOR12、CONR12R13或卤素取代的；R1、R2、R7和R8独立地是氢或C1-C6烷基；R3和R5在一起，R4和R6在一起形成一个未取代或被一个或多个C1-C4烷基取代的C2-C6烷基桥；R11是氢或C1-C6烷基；R12和R13独立地可以是氢、苯基、C1-C18烷基、被一个或多个O中断的C1-C18烷基；n为1-10；X为O、S或NR10；A和A1是适当的连接基团；它们适用于光致潜基。
• Actinic radiation-curable coating composition
  申请人：Van Den Berg Keimpe Jan

  公开号：US20100285234A1

  公开（公告）日：2010-11-11

  The invention relates to an actinic radiation-curable coating composition comprising a compound having at least two isocyanate groups, a compound having at least two hydroxyl groups, and a photolatent catalyst for the isocyanate-hydroxyl addition reaction, wherein the photolatent catalyst is an organic metal compound comprising a latent catalytically active metal, and wherein the latent catalytically active metal atom in the organic metal compound has no bonds to other metal atoms. The invention further relates to a process for forming a coating on a substrate.

  本发明涉及一种光固化涂料组合物，包括至少具有两个异氰酸酯基团的化合物、至少具有两个羟基团的化合物和一个光潜催化剂，用于异氰酸酯-羟基加成反应，其中光潜催化剂是一种有机金属化合物，包括潜在催化活性金属，其中有机金属化合物中的潜在催化活性金属原子没有与其他金属原子的键合。本发明还涉及一种在基底上形成涂层的方法。