5-nitro-naphthalene-2-sulfonyl chloride | 123091-55-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-nitro-naphthalene-2-sulfonyl chloride
• 英文别名: 5-Nitro-naphthalin-2-sulfonylchlorid；5-nitronaphthalen-2-ylsulfonyl chloride；5-Nitronaphthalene-2-sulfonyl chloride
• CAS: 123091-55-4
• 化学式: C₁₀H₆ClNO₄S
• 分子量: 271.681
• InChiKey: DBRNMMTUEGQIFD-UHFFFAOYSA-N

物化性质

• 熔点：
  109-145 °C
• 沸点：
  446.8±25.0 °C(Predicted)
• 密度：
  1.579±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-nitro-naphthalene-2-sulfonyl chloride 在 肼 作用下， 反应 2.0h， 生成 5-nitro-naphthalene-2-sulfonic acid-(D-ribo-2,6-dideoxy-hexitol-1-ylidenehydrazide)
  参考文献：
  名称：

  Westphal et al., Biochemische Zeitschrift, 1954, vol. 326, p. 139,145

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 五氯化磷 作用下， 生成 5-nitro-naphthalene-2-sulfonyl chloride
  参考文献：
  名称：

  Cleve, 1876, # 7, p. 53

  摘要：

  DOI：

文献信息

• [EN] NOVEL PRECURSORS OF GLUTAMATE DERIVATIVES<br/>[FR] NOUVEAUX PRÉCURSEURS DE DÉRIVÉS DU GLUTAMATE
  申请人：BAYER PHARMA AG

  公开号：WO2012150204A1

  公开（公告）日：2012-11-08

  This invention relates to novel precursors suitable for 18F radiolabeling of glutamate derivatives, methods for preparing such compounds and its intermediates, compositions comprising such compounds, kits comprising such compounds or compositions and methods for 18F radiolabeling of glutamate derivatives wherein the obtained 18F radiolabeled glutamate derivatives are suitable for diagnostic imaging by Positron Emission Tomography (PET) of proliferative diseases e.g. tumor in mammals.

  本发明涉及适用于谷氨酸衍生物18F放射标记的新型前体，制备这种化合物及其中间体的方法，包含这种化合物的组合物，包含这种化合物或组合物的试剂盒，以及18F放射标记谷氨酸衍生物的方法，其中获得的18F放射标记谷氨酸衍生物适用于通过正电子发射断层扫描（PET）对哺乳动物中的增殖性疾病（如肿瘤）进行诊断成像。
• Novel precursors of glutamate derivatives
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：EP2520557A1

  公开（公告）日：2012-11-07

  This invention relates to novel precursors suitable for 18F radiolabeling of glutamate derivatives, methods for preparing such compounds and its intermediates, compositions comprising such compounds, kits comprising such compounds or compositions and methods for 18F radiolabeling of glutamate derivatives wherein the obtained 18F radiolabeled glutamate derivatives are suitable for diagnostic imaging by Positron Emission Tomography (PET) of proliferative diseases e.g. tumor in mammals.

  本发明涉及适用于18F标记谷氨酸衍生物的新型前体，制备这种化合物及其中间体的方法，包含这种化合物的组合物，包含这种化合物或组合物的试剂盒，以及用于18F标记谷氨酸衍生物的方法。所得的18F标记谷氨酸衍生物适用于通过正电子发射断层扫描（PET）对哺乳动物的增殖性疾病，如肿瘤进行诊断成像。
• Hydantoin derivatives
  申请人：Mochida Pharmaceutical Co., Ltd.

  公开号：US05004751A1

  公开（公告）日：1991-04-02

  The present invention relates to novel hydantoin derivatives, processes for producing said hydantoin derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives as aldose reductase inhibitors and novel intermediate compounds in the synthesis of said hydantoin derivatives. The present invention is based on the selection of a hydantoin which is bonded by a sulfonyl group to various substituents at the 1-position of the hydantoin skeleton. The compounds of the present invention have a strong inhibitory activity against aldose reductase. These compounds are extremely useful for the treatment and/or prevention of various forms of diabetic complications based on the accumulation of polyol metabolites.

  本发明涉及新型咪唑烷酮衍生物，生产所述咪唑烷酮衍生物的方法，含有至少一种所述咪唑烷酮衍生物作为醛糖还原酶抑制剂的药物组合物，以及在合成所述咪唑烷酮衍生物中的新型中间化合物。本发明基于选择一种咪唑烷酮，该咪唑烷酮通过磺酰基与咪唑烷酮骨架的1位上的各种取代基结合。本发明的化合物对醛糖还原酶具有强烈的抑制活性。这些化合物对于治疗和/或预防基于多元醇代谢产物积累的各种糖尿病并发症非常有用。
• NOVEL PRECURSORS OF GLUTAMATE DERIVATIVES
  申请人：Hultsch Christina

  公开号：US20140243532A1

  公开（公告）日：2014-08-28

  This invention relates to novel precursors suitable for 18 F radiolabeling of glutamate derivatives, methods for preparing such compounds and its intermediates, compositions comprising such compounds, kits comprising such compounds or compositions and methods for 18 F radiolabeling of glutamate derivatives wherein the obtained 18 F radiolabeled glutamate derivatives are suitable for diagnostic imaging by Positron Emission Tomography (PET) of proliferative diseases e.g. tumor in mammals.

  本发明涉及适用于18F标记谷氨酸衍生物的新型前体，制备这种化合物及其中间体的方法，包含这种化合物的组合物，包含这种化合物或组合物的试剂盒以及18F标记谷氨酸衍生物的方法，其中所得的18F标记谷氨酸衍生物适用于通过正电子发射断层扫描（PET）对哺乳动物中的增生性疾病例如肿瘤进行诊断成像。
• Hydantoin derivatives, process for their preparation and pharmaceutical compositions containing the same as well as their use
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP0305947A1

  公开（公告）日：1989-03-08

  The present invention relates to novel hydantoin derivatives, processes for producing said hydantoin 'derivatives, pharmaceutical compositions containing at least one of said hydantoin derivatives as aldose reductase inhibitors and novel intermediate compounds in the synthesis of said hydantoin derivatives. The present invention is based on the selection of a hydantoin which is bonded by a sulfonyl group to various substituents at the 1-position of the hydantoin skeleton. The compounds of the present invention have a strong inhibitory activity against aldose reductase. These compounds are extremely useful for the treatment and/or prevention of various forms of diabetic complications based on the accumulation of polyol metabolites.

  本发明涉及新型海因衍生物、生产所述海因'衍生物的工艺、含有至少一种所述海因衍生物作为醛糖还原酶抑制剂的药物组合物以及合成所述海因衍生物的新型中间化合物。 本发明的基础是选择一种通过磺酰基键合在海因骨架 1 位上的各种取代基上的海因。 本发明的化合物对醛糖还原酶具有很强的抑制活性。这些化合物对于治疗和/或预防基于多元醇代谢产物积累的各种糖尿病并发症极为有用。