salicyl naphth-1-ylamine | 5343-69-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: salicyl naphth-1-ylamine
• 英文别名: 2-hydroxy-N-naphthalen-1-yl-benzamide；N-[1]naphthyl-salicylamide；N-[1]Naphthyl-salicylamid；2-Oxy-benzoesaeure-α-naphthylamid；Salicylsaeure-α-naphthylamid；N-(1-Naphthyl)-2-hydroxy-benzamid；N-1-Naphthylsalicylamide；2-hydroxy-N-naphthalen-1-ylbenzamide
• CAS: 5343-69-1
• 化学式: C₁₇H₁₃NO₂
• 分子量: 263.296
• InChiKey: KNDXRSHNJYVDFS-UHFFFAOYSA-N

物化性质

• 熔点：
  179-180 °C
• 沸点：
  391.8±25.0 °C(Predicted)
• 密度：
  1.310±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  salicyl naphth-1-ylamine 、 氯甲酸乙酯 在 吡啶 作用下， 生成 3-naphthalen-1-yl-benzo[e][1,3]oxazine-2,4-dione
  参考文献：
  名称：

  Wagner; Singer; Weuffen, Pharmazie, 1966, vol. 21, # 3, p. 161 - 166

  摘要：

  DOI：
• 作为产物：
  描述：

  1-萘胺 、 水杨酰氯 在 苯 作用下， 生成 salicyl naphth-1-ylamine
  参考文献：
  名称：

  Versuche zur Gewinnung einiger neuer Azofarbstoffe

  摘要：

  DOI：

  10.1007/bf01532301

文献信息

• Boron trichloride catalyzed ortho carbonylation of phenols:
  作者：Oreste Piccolo、Lucio Filippini、Laura Tinucci、Ermanno Valoti、Attilio Citterio

  DOI：10.1016/s0040-4020(01)87495-0

  日期：1986.1

  In the presence of equimolar quantity of BCl3, phenols 1 react with isocyanates and acyl chlorides to give, usually with good-excellent yields, 2-hydroxy-aryl-carboxy-amides 2 and 2-hydroxy-aryl-ketones 3 respectively. A distinctive behaviour of BCl3 in comparison with other Lewis acids is observed.

  在等摩尔量的BCl 3的存在下，酚1与异氰酸酯和酰氯反应，通常以优异的产率分别得到2-羟基-芳基-羧基酰胺2和2-羟基-芳基酮3。与其他路易斯酸相比，观察到BCl 3的独特行为。
• INFLAMMATORY CYTOKINE RELEASE INHIBITOR
  申请人：MUTO Susumu

  公开号：US20090192122A2

  公开（公告）日：2009-07-30

  A medicament having inhibitory activity against NF-κB activation, which comprises a compound represented by the following general formula (I) or a pharmacologically acceptable salt as an active ingredient: wherein X represents a connecting group, A represents hydrogen atom or acetyl group, E represents an aryl group or a heteroaryl group, and ring X represents an arene or a heteroarene.

  一种具有抑制NF-κB激活活性的药物，其包括以下通式(I)所表示的化合物或其药理学上可接受的盐作为活性成分：其中X代表连接基，A代表氢原子或乙酰基，E代表芳基或杂芳基，环X代表芳烃或杂芳烃。
• Inhibitors against the production and release of inflammatory cytokines
  申请人：——

  公开号：US20040259877A1

  公开（公告）日：2004-12-23

  A medicament having inhibitory activity against NF-&kgr;B activation, which comprises a compound represented by the following general formula (I) or a pharmacologically acceptable salt as an active ingredient: 1 wherein X represents a connecting group, A represents hydrogen atom or acetyl group, E represents an aryl group or a heteroaryl group, and ring X represents an arene or a heteroarene.

  一种具有抑制NF-&kgr;B激活活性的药物，其包括以下通式（I）所表示的化合物或其药学上可接受的盐作为活性成分：1其中X表示连接基，A表示氢原子或乙酰基，E表示芳基或杂芳基，环X表示芳烃或杂芳烃。
• INHIBITORS AGAINST THE PRODUCTION AND RELEASE OF INFLAMMATORY CYTOKINES
  申请人：Institute of Medicinal Molecular Design, Inc.

  公开号：EP1352650A1

  公开（公告）日：2003-10-15

  A medicament having inhibitory activity against NF- κ B activation, which comprises a compound represented by the following general formula (I) or a pharmacologically acceptable salt as an active ingredient: wherein X represents a connecting group, A represents hydrogen atom or acetyl group, E represents an aryl group or a heteroaryl group, and ring X represents an arene or a heteroarene.

  一种对 NF-κ B 活化具有抑制活性的药物，其活性成分包括下通式(I)所代表的化合物或药理学上可接受的盐： 其中，X 代表连接基团，A 代表氢原子或乙酰基，E 代表芳基或杂芳基，环 X 代表芳炔或杂芳炔。
• One-Pot Synthesis of Salicylanilides by Direct Amide Bond Formation from Salicyclic Acid Under Microwave Irradiation
  作者：Cheng-Rong Lu、Bei Zhao、Ying-Peng Jiang、Hao Ding、Sheng Yang

  DOI：10.1080/00397911.2010.481745

  日期：2011.4.5

  [image omitted] A highly efficient protocol for the preparation of aromatic amides is described by the direct reactions between salicyclic acid and aromatic amines in the presence of phosphorous trichloride under microwave irradiation. The method has several advantages over the conventional methods, including operational simplicity, good yield, and reduced reaction time.