1,5-Dimethyl-1H-indazole-3-carbonitrile | 1015846-71-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 1,5-Dimethyl-1H-indazole-3-carbonitrile
• 英文别名: 1,5-dimethylindazole-3-carbonitrile
• CAS: 1015846-71-5
• 化学式: C₁₀H₉N₃
• mdl: MFCD09971305
• 分子量: 171.2
• InChiKey: WWGCSCSQWJXPNB-UHFFFAOYSA-N

物化性质

• 沸点：
  335.8±22.0 °C(Predicted)
• 密度：
  1.16±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  41.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] NOVEL INDAZOLE COMPOUNDS AND A PROCESS FOR THE PREPARATION THEREOF<br/>[FR] NOUVEAUX COMPOSÉS D'INDAZOLE ET LEUR PROCEDE DE PREPARATION
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2015015519A1

  公开（公告）日：2015-02-05

  The patent discloses novel indazole compounds of general formula1 and analogues thereof, use thereof for the treatment of diabetes, diabetic complications, cardiovascular dysfuntion or related diseases, pharmaceutical compositions comprising them and processes for their preparation.

  该专利披露了一种一般式1的新型吲唑类化合物及其类似物，以及它们用于治疗糖尿病、糖尿病并发症、心血管功能障碍或相关疾病的用途，包括它们的药物组合物和制备过程。
• PEPTIDE COMPOUND AND METHOD FOR PRODUCING SAME, COMPOSITION FOR SCREENING USE, AND METHOD FOR SELECTING PEPTIDE COMPOUND
  申请人：FUJIFILM Corporation

  公开号：EP3604326A1

  公开（公告）日：2020-02-05

  An object of the present invention is to provide a novel cyclic peptide compound excellent in cell membrane permeability, a method for producing the same, a composition for screening use, and a method for selecting a cyclic peptide compound that binds to a target substance. According to the present invention, a peptide compound represented by Formula (1) or a salt thereof is provided. In the formula, the symbols have the meanings as defined in the specification of the present application.

  本发明的目的是提供一种细胞膜渗透性极佳的新型环肽化合物、一种生产该化合物的方法、一种用于筛选的组合物以及一种选择与目标物质结合的环肽化合物的方法。根据本发明，提供了一种由式（1）表示的多肽化合物或其盐。式中的符号具有本申请说明书中定义的含义。
• Peptide compound and method for producing same, composition for screening use, and method for selecting peptide compound
  申请人：FUJIFILM Corporation

  公开号：US11319347B2

  公开（公告）日：2022-05-03

  An object of the present invention is to provide a novel cyclic peptide compound excellent in cell membrane permeability, a method for producing the same, a composition for screening use, and a method for selecting a cyclic peptide compound that binds to a target substance. According to the present invention, a peptide compound represented by Formula (1) or a salt thereof is provided. In the formula, the symbols have the meanings as defined in the specification of the present application.

  本发明的目的是提供一种细胞膜渗透性极佳的新型环肽化合物、一种生产该化合物的方法、一种用于筛选的组合物以及一种选择与目标物质结合的环肽化合物的方法。根据本发明，提供了一种由式（1）表示的多肽化合物或其盐。式中的符号具有本申请说明书中定义的含义。
• NOVEL INDAZOLE COMPOUNDS AND A PROCESS FOR THE PREPARATION THEREOF
  申请人：Council of Scientific & Industrial Research

  公开号：EP3027605B1

  公开（公告）日：2017-11-08
• THERAPEUTIC COMPOUNDS AND USES THEREOF
  申请人：Genentech, Inc.

  公开号：EP3204360B1

  公开（公告）日：2020-08-26