1-(1-Isopropylcyclopropyl)methanamine | 1015846-33-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(1-Isopropylcyclopropyl)methanamine
• 英文别名: (1-propan-2-ylcyclopropyl)methanamine
• CAS: 1015846-33-9
• 化学式: C₇H₁₅N
• mdl: MFCD09971226
• 分子量: 113.2
• InChiKey: AGGHXCYXDNEQQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Purinone Derivatives as Tyrosine Kinase Inhibitors
  申请人：Principia Biopharma Inc.

  公开号：US20140142099A1

  公开（公告）日：2014-05-22

  The present disclosure provides compounds and pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, TEC, BTK, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as autoimmune diseases, cancer and inflammatory diseases. Also provided are pharmaceutical compositions containing such compounds and pharmaceutically acceptable salts thereof and processes for preparing such compounds and pharmaceutically acceptable salts thereof.

  本公开提供了一些酪氨酸激酶抑制剂及其药用盐，特别是BLK、BMX、EGFR、HER2、HER4、ITK、TEC、BTK和TXK，因此适用于治疗通过抑制酪氨酸激酶可治疗的疾病，如自身免疫疾病、癌症和炎症性疾病。还提供了含有这些化合物和药用盐的药物组合物，以及制备这些化合物和药用盐的方法。
• COMBINATION PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
  申请人：Liu Yi

  公开号：US20140357651A1

  公开（公告）日：2014-12-04

  The present invention provides for methods and pharmaceutical compositions for treating proliferative disorders. In one aspect, the method comprises administration of two cell-cycle suppressors having a synergistic effect. In another aspect, two cell-cycle suppressors having a synergistic effect are provided in a pharmaceutical composition.

  本发明提供了用于治疗增殖性疾病的方法和药物组合物。在一个方面，该方法包括给予具有协同作用的两种细胞周期抑制剂。在另一个方面，一种药物组合物中提供了具有协同作用的两种细胞周期抑制剂。
• Benzoxazole kinase inhibitors and methods of use
  申请人：Ren Pingda

  公开号：US20100184760A1

  公开（公告）日：2010-07-22

  The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as PI3 kinase. Also provided in the present invention are methods of using these compositions to modulate activities of one or more of these kinases, especially for therapeutic applications.

  本发明提供了一些化学实体或化合物及其制药组合物，这些实体或化合物能够调节某些蛋白激酶，例如mTor、酪氨酸激酶和/或脂质激酶，例如PI3激酶。本发明还提供了使用这些组合物来调节这些激酶中的一个或多个活性的方法，特别是用于治疗应用。
• HCV NS3 PROTEASE INHIBITORS
  申请人：BARA Thomas

  公开号：US20140057836A1

  公开（公告）日：2014-02-27

  The present invention relates to hepatitis C virus (HCV) NS3 protease inhibitors containing a spirocyclic moeity, uses of such compounds, and synthesis of such compounds.

  本发明涉及含有螺环结构的丙肝病毒（HCV）NS3蛋白酶抑制剂，以及这些化合物的用途和合成方法。
• TYROSINE KINASE INHIBITORS
  申请人：Principia Biopharma Inc.

  公开号：US20140303190A1

  公开（公告）日：2014-10-09

  The present disclosure provides compounds and pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, TEC, BTK, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer and inflammatory diseases such as arthritis, and the like. Also provided are pharmaceutical compositions containing such compounds and pharmaceutically acceptable salts thereof and processes for preparing such compounds and pharmaceutically acceptable salts thereof.

  本公开提供化合物及其药学上可接受的盐，它们是酪氨酸激酶抑制剂，特别是BLK、BMX、EGFR、HER2、HER4、ITK、TEC、BTK和TXK，因此可用于治疗通过抑制酪氨酸激酶治疗的疾病，如癌症和炎症性疾病，如关节炎等。还提供含有这些化合物及其药学上可接受的盐的药物组合物和制备这些化合物及其药学上可接受的盐的方法。