3-(丁基氨基)苯酚 | 58494-81-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 3-(丁基氨基)苯酚
• 英文名称: m-(n-Butylamino)phenol
• 英文别名: 3-(N-n-butylamino)phenol；3-(n-Butylamino)phenol；3-(butylamino)phenol
• CAS: 58494-81-8
• 化学式: C₁₀H₁₅NO
• 分子量: 165.235
• InChiKey: SUUUGHXWCICIAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(丁基氨基)苯酚 生成 间苯二酚
  参考文献：
  名称：

  Process for preparing 3-(N,N-disubstituted amino)phenol

  摘要：

  本文披露了一种制备3-(N,N-二取代氨基)苯酚的方法，包括将间苯二酚与式(2)表示的一级胺反应：R1NH2（2），其中R1是烷基、环烷基、烯基、烷氧基烷基、芳基或芳基烷基，当间苯二酚转化率达到50摩尔％或更高且N,N'-二取代-m-苯二胺副产物量为所用间苯二酚量的2摩尔％或更少时终止反应，向所得反应混合物中加入式(3)表示的烷基卤化物：R2X（3），其中R2是烷基或环烷基；X是卤素原子，然后向反应混合物中加入水性碱性溶液以溶解未反应的间苯二酚，用有机溶剂提取3-(N,N-二取代氨基)苯酚，然后从水相中回收未反应的间苯二酚。按照这种方法，可以从间苯二酚中制备高纯度的3-(N,N-二取代氨基)苯酚，产生副产物的生产被抑制。

  公开号：

  US05710335A1
• 作为产物：
  描述：

  N,N-二丁基间氨基苯酚 生成 3-(丁基氨基)苯酚
  参考文献：
  名称：

  Process for preparing 3-(N,N-disubstituted amino)phenol

  摘要：

  本文披露了一种制备3-(N,N-二取代氨基)苯酚的方法，包括将间苯二酚与式(2)表示的一级胺反应：R1NH2（2），其中R1是烷基、环烷基、烯基、烷氧基烷基、芳基或芳基烷基，当间苯二酚转化率达到50摩尔％或更高且N,N'-二取代-m-苯二胺副产物量为所用间苯二酚量的2摩尔％或更少时终止反应，向所得反应混合物中加入式(3)表示的烷基卤化物：R2X（3），其中R2是烷基或环烷基；X是卤素原子，然后向反应混合物中加入水性碱性溶液以溶解未反应的间苯二酚，用有机溶剂提取3-(N,N-二取代氨基)苯酚，然后从水相中回收未反应的间苯二酚。按照这种方法，可以从间苯二酚中制备高纯度的3-(N,N-二取代氨基)苯酚，产生副产物的生产被抑制。

  公开号：

  US05710335A1

文献信息

• QUENCHER
  申请人：Wako Pure Chemical Industries, Ltd.

  公开号：US20170342031A1

  公开（公告）日：2017-11-30

  A quencher is disclosed having a compound represented by the following general formula (1): wherein R 5 each independently represent a halogen atom, an alkyl group, an alkoxy group, an alkylthio group, an amino group having a substituent or not having a substituent, a hydroxy group, an aryl group, an aryloxy group, or an arylalkyl group; R 6 represents a group having a polymerizable unsaturated group, a hydroxy group, or the like; Y 1 represents an oxygen atom, or the like; An − represents an anion; Ar 1 represents a specific ring structure; * and ** represent binding positions; Ar 2 represents a benzene ring, a naphthalene ring, or an anthracene ring; n 1 represents a specific integer; and the following structure (1-10) in the general formula (1) is an asymmetric structure; (wherein R 5 , Y 1 , Ar 1 , Ar 2 , n 1 , * and ** are the same as described above.).

  一种淬灭剂被公开，该淬灭剂具有以下一般公式(1)表示的化合物： 其中R5各自独立代表一个卤素原子、一个烷基团、一个烷氧基团、一个烷硫基团、一个带有或不带有取代基的氨基团、一个羟基、一个芳基团、一个芳氧基团或一个芳烷基团；R6代表一个具有可聚合不饱和基团、一个羟基或类似基团的集团；Y1代表一个氧原子或类似；An代表一个阴离子；Ar1代表一个特定的环结构；*和**代表结合位置；Ar2代表一个苯环、一个萘环或一个蒽环；n1代表一个特定的整数； 并且一般公式(1)中的以下结构(1-10)是一个不对称结构； (其中R5、Y1、Ar1、Ar2、n1、*和**与上述描述相同)。
• The autorecycling oxidation of benzylamine by synthetic 8-hydroxy-5-deazaflavin derivatives
  作者：Ryoichi Hirayama、Masahiro Kawase、Tetsutaro Kimachi、Kiyoshi Tanaka、Fumio Yoneda

  DOI：10.1002/jhet.5570260509

  日期：1989.9

  Various 8-hydroxy-5-deazaflavin derivatives were synthesized as the model compounds of coenzyme F420-These compounds oxidized benzylamine to benzaldehyde more efficiently than the corresponding 8-unsubstituted 5-deazaflavins.

  合成了多种8-羟基-5-脱氮黄素衍生物作为辅酶F 420的模型化合物。这些化合物比相应的8-未取代的5-脱氮黄素更有效地将苄胺氧化为苯甲醛。
• Polyadducts produced from nonlinear-optically active copolymers and polymerizable nonlinear-optically active monomers
  申请人：Siemens Aktiengesellschaft

  公开号：US20010053818A1

  公开（公告）日：2001-12-20

  The present invention relates to nonlinear-optically active copolymers which are composed of a chromophore acrylate, a glycidyl-functional acrylate, and a further acrylate unit, and to polyadducts produced from them by crosslinking with a carboxyl-functional polyester. The nonlinear-optical copolymers of the present invention, and the polyadducts prepared from them, possess an orientation stability in the crosslinked state, and a thermal stability, which makes them highly suitable for producing electrooptical and photonic components.

  本发明涉及由色团丙烯酸酯、环氧基丙烯酸酯和另一丙烯酸酯单元组成的非线性光学活性共聚物，以及通过与羧基功能聚酯交联而产生的聚加物。本发明的非线性光学共聚物以及由其制备的聚加物，在交联状态下具有取向稳定性和热稳定性，使其非常适合用于制造电光和光子元件。
• 7-Alkylaminocoumarin-4-acetic acids as fluorescent probe for studies of drug-binding sites on human serum albumin.
  作者：Mitsuru IRIKURA、Akira TAKADATE、Shujiro GOYA、Masaki OTAGIRI

  DOI：10.1248/cpb.39.724

  日期：——

  7-Alkylaminocoumarin-4-acetic acids I-IX having alkylamino groups different in alkylchain length were synthesized as fluorescence probes for characterization of drug-binding sites on human serum albumin (HSA). The fluorescences of I-IX were quenched or enhanced in the presence of HSA with shifts of the emission maxima to shorter wavelength. The binding constants and the number of binding sites were determined by the spectral changes of the probes I-IX bound to HSA through analysis of Scatchard's and Job's plots. The primary binding sites of the tested probes were found to be site 2 (diazepam site) on HSA from the results of competitive displacement studies. The polarity of site 2 was estimated from the relationship between the emission maximum of the probe of IV and Z-values, and was found to be comparable to that of acetonitrile. Simple attempts to estimate the site 2 region from the molecular size of the probe of VIII obtained using the Corey-Pauling-Koltun molecular model suggest that the hydrophobic cleft at site 2 is about 21-25 Å in depth. The distance between the lone tryptophan residue in HSA and probes bound to site 2 was estimated to be 15-17 Å using Forster's equation on the basis of fluorescence energy transfer. The present data suggest that I-IX are useful as fluorescence probes for the characterization of site 2 on HSA.

  合成了9种具有不同烷基链长度的7-烷基氨基香豆酸-4-乙酸（I-IX），作为人血清白蛋白（HSA）药物结合位点特征化的荧光探针。在HSA存在下，I-IX的荧光被猝灭或增强，发射最大值向短波长移动。通过分析Scatchard和Job图，确定了与HSA结合的探针I-IX的结合常数和结合位点数量。竞争位移研究的结果表明，测试的探针的主要结合位点为HSA的位点2（地西泮位点）。利用探针IV的发射最大值与Z值之间的关系估算了位点2的极性，发现其与乙腈的极性相当。根据使用Corey-Pauling-Koltun分子模型获得的探针VIII的分子大小，简单尝试估算位点2区域，表明位点2的疏水裂缝深度约为21-25 Å。结合福斯特公式，基于荧光能量转移，估算HSA中孤立的色氨酸残基与结合在位点2的探针之间的距离为15-17 Å。目前的数据表明，I-IX作为荧光探针用于HSA位点2的特征化是有用的。
• Production of aminophenols
  申请人：Ciba Specialty Chemicals Corporation

  公开号：US05908961A1

  公开（公告）日：1999-06-01

  A method of producing N,N-disubstituted aminophenols of the general formula ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents a saturated or unsaturated aliphatic hydrocarbyl, cycloalkyl, aralkyl, the phenyl ring of which may be further substituted, alkoxyalkyl, or a cycloalkylalkyl, except that R.sub.1 and R.sub.2 are not simultaneously methyl and R' represents hydrogen, halogen, nitro, cyano, alkyl or alkoxy, which comprises reacting an aminophenol of general formula ##STR2## wherein R.sub.3 represents hydrogen or R.sub.1, and R' is as defined above, with an organic halide species of general formula R.sub.2 X wherein R.sub.2 is as defined above and X is halogen under aqueous acidic conditions with the periodic addition of an acid trapping agent in such a way that continuous monitoring of pH is not required.

  一种生产一般式为##STR1##的N,N-二取代氨基酚的方法，其中R.sub.1和R.sub.2相同或不同，每个代表饱和或不饱和的脂肪烃基、环烷基、芳基烷基，其苯环可能进一步取代、烷氧基烷基或环烷基烷基，但R.sub.1和R.sub.2不能同时是甲基，R'代表氢、卤素、硝基、氰基、烷基或烷氧基，包括在水性酸性条件下与一般式为R.sub.2 X的有机卤代物种反应，其中R.sub.2如上定义，X为卤素，并定期添加酸捕获剂，以使不需要连续监测pH。