1-benzofuran-2-carbaldehyde[4-(2-hydroxy-5-methoxyphenyl)-1,3-thiazol-2-yl]hydrazone | 1427161-68-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 1-benzofuran-2-carbaldehyde[4-(2-hydroxy-5-methoxyphenyl)-1,3-thiazol-2-yl]hydrazone
• 英文别名: 2-[2-[2-(Benzofuran-2-ylmethylene)hydrazino]thiazol-4-yl]-4-methoxy-phenol；2-[2-[2-(1-benzofuran-2-ylmethylidene)hydrazinyl]-1,3-thiazol-4-yl]-4-methoxyphenol
• CAS: 1427161-68-9
• 化学式: C₁₉H₁₅N₃O₃S
• 分子量: 365.412
• InChiKey: SKWVUCORPMGQPR-UHFFFAOYSA-N

物化性质

• 沸点：
  574.9±60.0 °C(predicted)
• 密度：
  1.39±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  苯并[b]呋喃-2-甲醛 在 吡啶 作用下， 以 乙醇 为溶剂， 反应 8.0h， 生成 1-benzofuran-2-carbaldehyde[4-(2-hydroxy-5-methoxyphenyl)-1,3-thiazol-2-yl]hydrazone
  参考文献：
  名称：

  Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives

  摘要：

  Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans species. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.01.039

文献信息

• Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives
  作者：Ludovic T. Maillard、Sébastien Bertout、Ophélie Quinonéro、Gülşen Akalin、Gülhan Turan-Zitouni、Pierre Fulcrand、Fatih Demirci、Jean Martinez、Nicolas Masurier

  DOI：10.1016/j.bmcl.2013.01.039

  日期：2013.3

  Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans species. (C) 2013 Elsevier Ltd. All rights reserved.