ORG-25935 free base | 1147011-84-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: ORG-25935 free base
• 英文别名: 2-[[(1R,2S)-6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl]methyl-methylamino]acetic acid
• CAS: 1147011-84-4
• 化学式: C₂₁H₂₅NO₃
• 分子量: 339.4
• InChiKey: UEBBYLJZCHTLEG-UTKZUKDTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
  申请人：Nlife Therapeutics S.L.

  公开号：EP2380595A1

  公开（公告）日：2011-10-26

  The invention provides a conjugate comprising (i) a nucleic acid which is complementary to a target nucleic acid sequence and which expression prevents or reduces expression of the target nucleic acid and (ii) a selectivity agent which is capable of binding with high affinity to a neurotransmitter transporter. The conjugates of the present invention are useful for the delivery of the nucleuc acid toi cell of interests and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of contrast agents to the cells for diagnostic purposes.

  本发明提供了一种共轭物，该共轭物包含(i)与靶核酸序列互补的核酸，该核酸的表达可防止或减少靶核酸的表达；(ii)能够与神经递质转运体高亲和力结合的选择剂。本发明的共轭物可用于将核酸递送至相关细胞，从而治疗需要下调靶核酸编码蛋白的疾病，也可用于将造影剂递送至细胞以进行诊断。
• AMINOMETHYLCARBOXYLIC ACID DERIVATIVES
  申请人：Akzo Nobel N.V.

  公开号：EP1100769B1

  公开（公告）日：2002-12-04
• GLYCINE REUPTAKE INHIBITORS FOR TREATING DRUG AND ALCOHOL DEPENDENCE
  申请人：N.V. Organon

  公开号：EP1841418A2

  公开（公告）日：2007-10-10
• Glycine reuptake inhibitors for treating drug and alcohol dependence
  申请人：MSD Oss B.V.

  公开号：EP1841418B1

  公开（公告）日：2013-04-17
• COMPOSITIONS AND METHODS FOR SELECTIVE DELIVERY OF OLIGONUCLEOTIDE MOLECULES TO SPECIFIC NEURON TYPES
  申请人：Nlife Therapeutics S.L.

  公开号：EP2560687B1

  公开（公告）日：2017-05-24