7-Chloro-4-(1-ethylpiperidin-4-yl)-3-methylisoquinolin-1(2H)-one | 702709-38-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 7-Chloro-4-(1-ethylpiperidin-4-yl)-3-methylisoquinolin-1(2H)-one
• 英文别名: 7-chloro-4-(1-ethylpiperidin-4-yl)-3-methyl-2H-isoquinolin-1-one
• CAS: 702709-38-4
• 化学式: C₁₇H₂₁ClN₂O
• 分子量: 304.8
• InChiKey: AMDFFHFXVWPBCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Isoquinoline compounds and medicinal use thereof
  申请人：Fujio Masakazu

  公开号：US20060094743A1

  公开（公告）日：2006-05-04

  The present invention relates to an isoquinoline compound represented by the following formula (I) or (II), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction.

  本发明涉及一种由以下式(I)或(II)表示的异喹啉化合物，其光学活性形式，其药学上可接受的盐，其水加合物，其水合物和其溶剂化物，以及一种含有该化合物的用于预防和/或治疗由多聚(ADP-核糖)聚合酶过度反应引起的疾病的药剂，以及一种含有该化合物的多聚(ADP-核糖)聚合酶抑制剂。此外，该化合物对于预防和/或治疗脑梗死非常有用，特别是对于预防和/或治疗急性脑梗死。
• ISOQUINOLINE COMPOUNDS AND MEDICINAL USE THEREOF
  申请人：Mitsubishi Pharma Corporation

  公开号：EP1566380A1

  公开（公告）日：2005-08-24

  The present invention relates to an isoquinoline compound represented by the following formula (I) or (II), an optically active form thereof, a pharmaceutically acceptable salt thereof, a water adduct thereof, a hydrate thereof and a solvate thereof, as well as an agent for the prophylaxis and/or treatment of a disease caused by hyperreactivity of poly(ADP-ribose)polymerase, containing the compound, and a poly(ADP-ribose)polymerase inhibitor containing the compound. In addition, this compound is useful as an agent for the prophylaxis and/or treatment of cerebral infarction, particularly as an agent for the prophylaxis and/or treatment of acute cerebral infarction.

  本发明涉及下式(I)或(II)代表的异喹啉化合物、其光学活性形式、其药学上可接受的盐、其水加成物、其水合物和其溶解物，以及含有该化合物的预防和/或治疗由聚(ADP-核糖)聚合酶高反应性引起的疾病的制剂和含有该化合物的聚(ADP-核糖)聚合酶抑制剂。此外，该化合物还可作为预防和/或治疗脑梗塞的药物，特别是作为预防和/或治疗急性脑梗塞的药物。
• US7501412B2
  申请人：——

  公开号：US7501412B2

  公开（公告）日：2009-03-10