4,5,6,7-tetrahydro-1-methyl-4-(2-(morpholin-4-yl)ethyl)-1H-indazole | 878021-44-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4,5,6,7-tetrahydro-1-methyl-4-(2-(morpholin-4-yl)ethyl)-1H-indazole
• 英文别名: 4,5,6,7-Tetrahydro-1-methyl-4-[2-(4-morpholinyl)ethyl]-1H-indazole；4-[2-(1-methyl-4,5,6,7-tetrahydroindazol-4-yl)ethyl]morpholine
• CAS: 878021-44-4
• 化学式: C₁₄H₂₃N₃O
• 分子量: 249.356
• InChiKey: RYOMPQZSKYAHDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  30.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Sigma receptor inhibitors
  申请人：Arjona Corbera Jordi

  公开号：US20060047127A1

  公开（公告）日：2006-03-02

  The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to some pyrazole derivatives, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use therapy and prophylaxis, in particular for the treatment of psychosis or pain.

  本发明涉及具有对sigma受体的药理活性的化合物，更特别地涉及一些吡唑衍生物，制备这些化合物的过程，包含它们的制药组合物，以及它们在治疗和预防中的使用，尤其是用于治疗精神病或疼痛。
• Sigma ligands for use in the prevention and/or treatment of postoperative pain
  申请人：Laboratorios del. Dr. Esteve, S.A.

  公开号：EP2353598A1

  公开（公告）日：2011-08-10

  The invention refers to the use of a sigma ligand, particularly a sigma ligand of formulae (I), (II) or (III) to prevent and/or treat acute and chronic pain developed as a consequence of surgery, especially superficial and/or deep pain secondary to surgical tissue injury, and peripheral neuropathic pain, neuralgia, allodynia, causalgia, hyperalgesia, hyperesthesia, hyperpathia, neuritis or neuropathy secondary to surgical procedure.

  本发明涉及使用sigma配体，特别是公式（I），（II）或（III）的sigma配体，以预防和/或治疗由手术引起的急性和慢性疼痛，特别是手术组织损伤引起的表浅和/或深层疼痛，以及周围神经病理性疼痛，神经痛，触痛，烧伤性痛，痛觉过敏，疼痛过敏，神经炎或手术过程引起的神经病变。
• Sigma Receptor Inhibitors
  申请人：Corbera Arjona Jordi

  公开号：US20070232585A1

  公开（公告）日：2007-10-04

  The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to pyrazole derivatives of formula (I) and to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use therapy and prophylaxis, in particular for the treatment of psychosis or pain.

  本发明涉及具有对sigma受体具有药理活性的化合物，更具体地涉及公式(I)的吡唑衍生物以及制备这些化合物的方法，包括它们的制药组合物，以及它们在治疗和预防中的应用，特别是用于治疗精神病或疼痛。
• SUBSTITUTED PYRAZOLE SIGMA RECEPTOR ANTAGONISTS
  申请人：CORBERA ARJONA Jordi

  公开号：US20110015183A1

  公开（公告）日：2011-01-20

  The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to pyrazole derivatives of formula I and to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use therapy and prophylaxis, in particular for the treatment of psychosis or pain.

  本发明涉及具有对sigma受体具有药理活性的化合物，更具体地涉及公式I的吡唑衍生物以及制备这些化合物的方法，包括它们的制药组合物，以及它们在治疗和预防方面的用途，特别是用于治疗精神病或疼痛。
• Sigma ligands for the prevention or treatment of pain induced by chemotherapy
  申请人：Laboratorios del. Dr. Esteve, S.A.

  公开号：EP2292237A1

  公开（公告）日：2011-03-09

  The invention refers to the use of a sigma ligand of formula (I) to prevent or treat pain induced by a chemotherapeutic agent, especially pain induced by taxanes, vinca alkaloids or platinum derivatives chemotherapeutic drugs.

  本发明是指使用式（I）的σ配体来预防或治疗由化疗药物引起的疼痛，特别是由紫杉类、长春花生物碱或铂衍生物化疗药物引起的疼痛。