2-[5-(4-phenylpiperidin-4-yl)-tetrazol-2-yl]-acetamide | 862287-83-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-[5-(4-phenylpiperidin-4-yl)-tetrazol-2-yl]-acetamide
• 英文别名: 2-[5-(4-Phenylpiperidin-4-yl)tetrazol-2-yl]acetamide
• CAS: 862287-83-0
• 化学式: C₁₄H₁₈N₆O
• 分子量: 286.337
• InChiKey: CZBDXAWWOXTMMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  98.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-[5-(4-phenylpiperidin-4-yl)-tetrazol-2-yl]-acetamide 、 3,3-二苯基四氢呋喃-2-亚基二甲基溴化胺 在 sodium carbonate 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 生成 4-[4-(2-carbamoylmethyl-2H-tetrazol-5-yl)-4-phenyl-piperidin-1-yl]-N,N-dimethyl-2-2-diphenyl-butyramide
  参考文献：
  名称：

  [EN] METHODS FOR MAKING 4-TETRAZOLYL-4-PHENYLPIPERIDINE COMPOUNDS
  [FR] PROCEDES D'ELABORATION DE COMPOSES DE 4-TETRAZOLYL-4-PHENYLPIPERIDINE

  摘要：

  公开号：

  WO2005075455A3
• 作为产物：
  描述：

  2-[5-(1-benzyl-4-phenylpiperidin-4-yl)-tetrazol-2-yl]-acetamide 在 palladium 10% on activated carbon 氢气 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 2-[5-(4-phenylpiperidin-4-yl)-tetrazol-2-yl]-acetamide
  参考文献：
  名称：

  [EN] METHODS FOR MAKING 4-TETRAZOLYL-4-PHENYLPIPERIDINE COMPOUNDS
  [FR] PROCEDES D'ELABORATION DE COMPOSES DE 4-TETRAZOLYL-4-PHENYLPIPERIDINE

  摘要：

  公开号：

  WO2005075455A3

文献信息

• METHODS FOR MAKING 4-TETRAZOLYL-4-PHENYLPIPERIDINE COMPOUNDS
  申请人：EURO-CELTIQUE S.A.

  公开号：EP1709029A2

  公开（公告）日：2006-10-11
• Methods for making 4-tetrazolyl-4-phenylpiperidine compounds
  申请人：Brown Kevin

  公开号：US20070072909A1

  公开（公告）日：2007-03-29

  Methods, composition, and intermediates are disclosed that are useful for making 4-Tetrazolyl-4-phenylpiperidine Compounds according to Formula I, where Ar 1 is —C 3 -C 8 cycloalkyl, phenyl, naphthyl, anthryl, phenanthryl or -(5-7-membered) heteroaryl, each being unsubstituted or substituted with one or more R 2 groups; Ar 2 is phenyl, naphthyl, anthryl, phenanthryl or -(5-7-membered) heteroaryl, each being unsubstituted or substituted with one or more R 2 groups; Z 1 and Z 2 are each independently a —(C 1 -C 4 alkyl) group; R 1 is —(CH 2 ) n C(O)N(R 3 )(R 4 ) where R 3 and R 4 are each independently H or —(C 1 -C 4 alkyl); R 2 is halogen, —C 1 -C 3 alkyl, —O—(C 1 -C 3 alkyl), —NH(C 1 -C 3 alkyl) or —N(C 1 -C 3 alkyl) 2 ; n is an integer ranging from 1 to 4; m is an integer ranging from 0 to 4; and, in certain embodiments, the phenyl moiety attached to the 4-position of the piperidine ring of a compound according to Formula I can be optionally substituted with one or more R 2 groups.
• US7557219B2
  申请人：——

  公开号：US7557219B2

  公开（公告）日：2009-07-07
• US8039636B2
  申请人：——

  公开号：US8039636B2

  公开（公告）日：2011-10-18
• [EN] METHODS FOR MAKING 4-TETRAZOLYL-4-PHENYLPIPERIDINE COMPOUNDS<br/>[FR] PROCEDES D'ELABORATION DE COMPOSES DE 4-TETRAZOLYL-4-PHENYLPIPERIDINE
  申请人：EURO CELTIQUE SA

  公开号：WO2005075455A3

  公开（公告）日：2005-12-15