4-(6-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-ylmethyl)-phenol | 835916-92-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(6-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-ylmethyl)-phenol
• 英文别名: 4-[(6-Phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl]phenol
• CAS: 835916-92-2
• 化学式: C₁₇H₁₃N₅O
• 分子量: 303.323
• InChiKey: KJLXDZHLCUBLIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  76.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Triazolotriazine compounds and uses thereof
  申请人：Zhang Fang-Jie

  公开号：US20050075340A1

  公开（公告）日：2005-04-07

  The present invention relates to compounds of the Formula (I), and their pharmaceutically acceptable salts. These compounds modulate the activity of c-Met and are therefore expected to be useful in the prevention and treatment of c-Met related disorders such as cancer.

  本发明涉及式(I)化合物及其药学上可接受的盐。这些化合物调节c-Met的活性，因此预计在预防和治疗与c-Met相关的疾病，如癌症方面有用。
• METHODS AND GENE EXPRESSION SIGNATURE FOR ASSESSING GROWTH FACTOR SIGNALING PATHWAY REGULATION STATUS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2265943A2

  公开（公告）日：2010-12-29
• METHODS AND GENE EXPRESSION SIGNATURE FOR ASSESSING RAS PATHWAY ACTIVITY
  申请人：Loboda Andrey

  公开号：US20100280987A1

  公开（公告）日：2010-11-04

  Methods, biomarkers, and expression signatures are disclosed for assessing the regulation status of RAS pathway signaling in a cell sample or subject. More specifically, several aspects of the invention provide a set of genes which can be used as biomarkers and gene signatures for evaluating RAS pathway deregulation status in a sample; classifying a cell sample as having a deregulated or regulated RAS signaling pathway; determining whether an agent modulates the RAS signaling pathway in sample; predicting response of a subject to an agent that modulates the RAS signaling pathway; assigning treatment to a subject; and evaluating the pharmacodynamic effects of cancer therapies designed to regulate RAS pathway signaling.
• Compositions and Methods for Treating Cancer
  申请人：Chemo-Enchanced LLC

  公开号：US20160051500A1

  公开（公告）日：2016-02-25

  The present invention provides, in part, compositions and methods for treating cancer using a combination of C6-ceramide and other anti-cancer agents in certain vesicles.
• US7122548B2
  申请人：——

  公开号：US7122548B2

  公开（公告）日：2006-10-17