6-Chloro-benzo[e][1,3]oxazine-2-thione | 647849-60-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 6-Chloro-benzo[e][1,3]oxazine-2-thione
• 英文别名: 2H-1,3-Benzoxazine-2-thione, 6-chloro-；6-chloro-1,3-benzoxazine-2-thione
• CAS: 647849-60-3
• 化学式: C₈H₄ClNOS
• 分子量: 197.645
• InChiKey: KOYINAOGILQYOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  [(Z)-(5-chloro-2-hydroxyphenyl)methylideneamino]thiourea 在 montmorillonite K-10 作用下， 反应 0.17h， 以92%的产率得到6-Chloro-benzo[e][1,3]oxazine-2-thione
  参考文献：
  名称：

  Mineral supported syntheses of benzoxazine-2-thiones under microwave irradiation

  摘要：

  An original montmorillonite K-10 clay catalysed cycloisomerisation of salicylaldehyde 4-arylthiosemicarbazones yields 3,4-dihydro-4-hydrazino-2H-benz[e]-1,3-oxazine-2-thiones, which on reductive dehydrazination on alumina-supported copper(II) sulfate readily furnish 3,4-dihydro-2H-benz[e]-1,3-oxazine-2-thiones under solvent-free microwave irradiation. Under the same conditions salicylaldehyde thiosemicarbazones undergo cyclodehydrazination to yield 2H-benz[e]-1,3-oxazine-2-thiones. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2003.10.085

文献信息

• Mineral supported syntheses of benzoxazine-2-thiones under microwave irradiation
  作者：Lal Dhar S. Yadav、Beerendra S. Yadav、Suman Dubey

  DOI：10.1016/j.tet.2003.10.085

  日期：2004.1

  An original montmorillonite K-10 clay catalysed cycloisomerisation of salicylaldehyde 4-arylthiosemicarbazones yields 3,4-dihydro-4-hydrazino-2H-benz[e]-1,3-oxazine-2-thiones, which on reductive dehydrazination on alumina-supported copper(II) sulfate readily furnish 3,4-dihydro-2H-benz[e]-1,3-oxazine-2-thiones under solvent-free microwave irradiation. Under the same conditions salicylaldehyde thiosemicarbazones undergo cyclodehydrazination to yield 2H-benz[e]-1,3-oxazine-2-thiones. (C) 2003 Elsevier Ltd. All rights reserved.