7-Amino-4,5-dimethyl-phenoxazon-(2) | 53669-97-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 7-Amino-4,5-dimethyl-phenoxazon-(2)
• 英文别名: 3H-Phenoxazin-3-one, 7-amino-1,9-dimethyl-；7-amino-1,9-dimethylphenoxazin-3-one
• CAS: 53669-97-9
• 化学式: C₁₄H₁₂N₂O₂
• 分子量: 240.261
• InChiKey: WZBUNYZYALKMCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  64.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Complex formed by N-linked glycoproteins (SIBLINGS) and Factor H
  申请人：Fisher W. Larry

  公开号：US20060078945A1

  公开（公告）日：2006-04-13

  The invention provides methods and compositions for exploiting the discovery that members of the small integrin-binding ligand, n-linked glycoproteins family termed SIBLINGS bind to complement Factor H, and moreover that SIBLINGS proteins, such as BSP, exist in relatively acidic forms. The methods provided can be used to detect SIBLINGS proteins in samples from subjects that are suspected of having tumors or abnormal bone turnover. The invention also provides methods of using SIBLINGS proteins to protect cells from complement mediated lysis. Finally, the discovery allows for the creation of specific binding agents that facilitate the detection of SIBLINGS proteins when they are associated with Factor H.

  本发明提供了利用以下发现的方法和组合物：被称为 SIBLINGS 的小整合素结合配体、n-连接糖蛋白家族的成员与补体因子 H 结合，而且 SIBLINGS 蛋白，如 BSP，以相对酸性的形式存在。本发明提供的方法可用于检测怀疑患有肿瘤或骨质异常的受试者样本中的 SIBLINGS 蛋白。本发明还提供了使用 SIBLINGS 蛋白保护细胞免受补体介导的裂解的方法。最后，本发明还提供了特异性结合剂，当 SIBLINGS 蛋白与 H 因子结合时，这种结合剂有助于检测 SIBLINGS 蛋白。
• COMPLEX FORMED BY N-LINKED GLYCOPROTEINS (SIBLINGS) AND FACTOR H
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：EP1169642B1

  公开（公告）日：2006-01-04
• NEUE ARZNEIMITTEL UND DIAGNOSTISCHE ZUSAMMENSETZUNGEN F R BE HANDLUNG UND DIAGNOSE VON NEURODEGENERATIVEN ERKRANKUNGEN UND AMYLOID-KRANKHEITEN
  申请人：MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN

  公开号：EP1713457A2

  公开（公告）日：2006-10-25
• Novel pharmaceutical and diagnostic compositions for use in the treatment and diagnosis of neurodegenerative diseases or amyloid diseases
  申请人：Wanker Erich

  公开号：US20090117040A1

  公开（公告）日：2009-05-07

  The present invention relates to pharmaceutical and diagnostic compositions as well as to the use of the active substances contained therein for preparing a pharmaceutical or a diagnostic composition for the treatment or diagnosis of neurodegenerative disorders or amyloid diseases.
• US6995018B1
  申请人：——

  公开号：US6995018B1

  公开（公告）日：2006-02-07