(Z,3S)-N-[[[(Z,3S)-2,6-dimethylhept-4-en-3-yl]amino]-ethenylphosphoryl]-2,6-dimethylhept-4-en-3-amine | 281658-59-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: (Z,3S)-N-[[[(Z,3S)-2,6-dimethylhept-4-en-3-yl]amino]-ethenylphosphoryl]-2,6-dimethylhept-4-en-3-amine
• CAS: 281658-59-1
• 化学式: C₂₀H₃₉N₂OP
• 分子量: 354.516
• InChiKey: RNUXJFJVFQLSRL-JVANIMHPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (Z,3S)-N-[[[(Z,3S)-2,6-dimethylhept-4-en-3-yl]amino]-ethenylphosphoryl]-2,6-dimethylhept-4-en-3-amine 在 Grubbs catalyst first generation 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 生成 ((Z)-(S)-1-Isopropyl-4-methyl-pent-2-enyl)-((2R,5S)-5-isopropyl-2-oxo-2,5-dihydro-1H-2λ⁵-[1,2]azaphosphol-2-yl)-amine
  参考文献：
  名称：

  Diastereotopic Differentiation on Phosphorus Templates via the Ring-Closing Metathesis Reaction

  摘要：

  [GRAPHICS]A strategy is described in which the ring-closing metathesis reaction is utilized to desymmetrize a number of pseudo-CL-symmetric phosphorus templates 1-3. These reactions give excellent levels of selectivity (12-15:1) with vinyl phosphonamides containing a (E)-Ph group on the diastereotopic olefins. This approach is being developed as an effective method of obtaining P-chiral phosphonamides and phosphonates.

  DOI：

  10.1021/ol005952o
• 作为产物：
  描述：

  (Z)-2,6-dimethylhept-4-en-3-amine 、 乙烯基膦酰氯 在 三乙胺 作用下， 以 甲苯 为溶剂， 以60.5%的产率得到(Z,3S)-N-[[[(Z,3S)-2,6-dimethylhept-4-en-3-yl]amino]-ethenylphosphoryl]-2,6-dimethylhept-4-en-3-amine
  参考文献：
  名称：

  Diastereotopic Differentiation on Phosphorus Templates via the Ring-Closing Metathesis Reaction

  摘要：

  [GRAPHICS]A strategy is described in which the ring-closing metathesis reaction is utilized to desymmetrize a number of pseudo-CL-symmetric phosphorus templates 1-3. These reactions give excellent levels of selectivity (12-15:1) with vinyl phosphonamides containing a (E)-Ph group on the diastereotopic olefins. This approach is being developed as an effective method of obtaining P-chiral phosphonamides and phosphonates.

  DOI：

  10.1021/ol005952o

文献信息

• Diastereotopic Differentiation on Phosphorus Templates via the Ring-Closing Metathesis Reaction
  作者：Diana S. Stoianova、Paul R. Hanson

  DOI：10.1021/ol005952o

  日期：2000.6.1

  [GRAPHICS]A strategy is described in which the ring-closing metathesis reaction is utilized to desymmetrize a number of pseudo-CL-symmetric phosphorus templates 1-3. These reactions give excellent levels of selectivity (12-15:1) with vinyl phosphonamides containing a (E)-Ph group on the diastereotopic olefins. This approach is being developed as an effective method of obtaining P-chiral phosphonamides and phosphonates.