2-cyano-4-methylquinazoline | 37920-78-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-cyano-4-methylquinazoline
• 英文别名: 2-Cyan-4-methylchinazolin；4-methyl-quinazoline-2-carbonitrile；4-Methylquinazoline-2-carbonitrile
• CAS: 37920-78-8
• 化学式: C₁₀H₇N₃
• 分子量: 169.186
• InChiKey: FXPWVOJXMFYQHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  49.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-[N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)]acetophenone 在 titanium(III) chloride 、 盐酸羟胺 作用下， 以 吡啶 、 甲醇 为溶剂， 反应 72.67h， 生成 2-cyano-4-methylquinazoline
  参考文献：
  名称：

  A Facile Synthesis of N-Arylcyanoformamidoximes, 4-Aryl-3-cyano-1,2,4-oxadiazin-5(6H)-ones, 2-Cyanoquinazoline-3-oxides, and 2-Cyanoquinazolines via 5-Arylimino-4-chloro-5H-1,2,3-dithiazoles

  摘要：

  DOI：

  10.3987/com-99-8666

文献信息

• Preparation of Heteroarenecarbonitriles by Reaction of Heteroarene N-Oxides with Trimethylsilyl Cyanide in the Presence of DBU
  作者：Akira Miyashita、Touru Kawashima、Chihoko Iijima、Takeo Higashino

  DOI：10.3987/com-91-s12

  日期：——

  Several heteroarenecarbonitriles were prepared from the corresponding heteroarene N-oxides by treatment with trimethylsilyl cyanide (TMSCN) in the presence of a base in tetrahydrofuran (THF). 1,8-Diazabicyclo[5.4.0]-7-undecene (DBU) was found to be an effective base for the cyanation.
• NITROGEN-CONTAINING CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING SAME
  申请人：LG CHEM, LTD.

  公开号：US20170213984A1

  公开（公告）日：2017-07-27

  The present specification provides a nitrogen-containing condensed cyclic compound of chemical formula 1 and an organic light emitting device comprising the same.
• [EN] INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF<br/>[FR] INHIBITEURS DE PROTÉASES À CYSTÉINE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：PARDES BIOSCIENCES INC

  公开号：WO2021212039A1

  公开（公告）日：2021-10-21

  The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.
• A Facile Synthesis of N-Arylcyanoformamidoximes, 4-Aryl-3-cyano-1,2,4-oxadiazin-5(6H)-ones, 2-Cyanoquinazoline-3-oxides, and 2-Cyanoquinazolines via 5-Arylimino-4-chloro-5H-1,2,3-dithiazoles
  作者：Kyongtae Kim、Yong-Goo Chang

  DOI：10.3987/com-99-8666

  日期：——