3-(N-ethyl-N-isopentylamino)phenol | 112008-26-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-(N-ethyl-N-isopentylamino)phenol
• 英文别名: 3-(N-Ethyl-N-isoamylamino)phenol；N-isopentyl-N-ethyl-m-aminophenol；N-ethyl-N-isoamyl-m-aminophenol；Phenol, 3-[ethyl(3-methylbutyl)amino]-；3-[ethyl(3-methylbutyl)amino]phenol
• CAS: 112008-26-1
• 化学式: C₁₃H₂₁NO
• 分子量: 207.316
• InChiKey: IXTNODIUFUYXQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(N-ethyl-N-isopentylamino)phenol 生成 3-(3-甲基丁基氨基)苯酚
  参考文献：
  名称：

  Process for preparing 3-(N,N-disubstituted amino)phenol

  摘要：

  本文披露了一种制备3-(N,N-二取代氨基)苯酚的方法，包括将间苯二酚与式(2)表示的一级胺反应：R1NH2（2），其中R1是烷基、环烷基、烯基、烷氧基烷基、芳基或芳基烷基，当间苯二酚转化率达到50摩尔％或更高且N,N'-二取代-m-苯二胺副产物量为所用间苯二酚量的2摩尔％或更少时终止反应，向所得反应混合物中加入式(3)表示的烷基卤化物：R2X（3），其中R2是烷基或环烷基；X是卤素原子，然后向反应混合物中加入水性碱性溶液以溶解未反应的间苯二酚，用有机溶剂提取3-(N,N-二取代氨基)苯酚，然后从水相中回收未反应的间苯二酚。按照这种方法，可以从间苯二酚中制备高纯度的3-(N,N-二取代氨基)苯酚，产生副产物的生产被抑制。

  公开号：

  US05710335A1

文献信息

• QUENCHER
  申请人：Wako Pure Chemical Industries, Ltd.

  公开号：US20170342031A1

  公开（公告）日：2017-11-30

  A quencher is disclosed having a compound represented by the following general formula (1): wherein R 5 each independently represent a halogen atom, an alkyl group, an alkoxy group, an alkylthio group, an amino group having a substituent or not having a substituent, a hydroxy group, an aryl group, an aryloxy group, or an arylalkyl group; R 6 represents a group having a polymerizable unsaturated group, a hydroxy group, or the like; Y 1 represents an oxygen atom, or the like; An − represents an anion; Ar 1 represents a specific ring structure; * and ** represent binding positions; Ar 2 represents a benzene ring, a naphthalene ring, or an anthracene ring; n 1 represents a specific integer; and the following structure (1-10) in the general formula (1) is an asymmetric structure; (wherein R 5 , Y 1 , Ar 1 , Ar 2 , n 1 , * and ** are the same as described above.).

  一种淬灭剂被公开，该淬灭剂具有以下一般公式(1)表示的化合物： 其中R5各自独立代表一个卤素原子、一个烷基团、一个烷氧基团、一个烷硫基团、一个带有或不带有取代基的氨基团、一个羟基、一个芳基团、一个芳氧基团或一个芳烷基团；R6代表一个具有可聚合不饱和基团、一个羟基或类似基团的集团；Y1代表一个氧原子或类似；An代表一个阴离子；Ar1代表一个特定的环结构；*和**代表结合位置；Ar2代表一个苯环、一个萘环或一个蒽环；n1代表一个特定的整数； 并且一般公式(1)中的以下结构(1-10)是一个不对称结构； (其中R5、Y1、Ar1、Ar2、n1、*和**与上述描述相同)。
• ベンゾフェノン誘導体の製造方法
  申请人：三井化学株式会社

  公开号：JP2005298458A

  公开（公告）日：2005-10-27

  PROBLEM TO BE SOLVED: To provide a method for producing a benzophenone derivative low in rhodamine-type dye content and having asymmetric alkyl groups.

  SOLUTION: The method for producing the benzophenone derivative of the general formula(2) comprises the following process: A reaction is carried out between a compound of the general formula(1) and phthalic anhydride in the presence of an organic solvent, the resultant reaction liquid is charged with water to adjust the reaction liquid to pH4.0-7.0, an organic solvent layer obtained by separating the reaction liquid in two is charged with water to adjust the organic solvent layer to pH8.0-14.0, and an aqueous layer obtained by separating the organic solvent layer in two is mixed with a water-miscible organic solvent to deposit crystal, which is then separated by filtration. In the general formulas(1) and (2), R1 and R2 are each an alkyl, cycloalkyl, alkoxyalkyl, benzyl or (substituted) phenyl group, wherein R1 and R2 are not the same as each other.

  COPYRIGHT: (C)2006,JPO&NCIPI

  解决的问题：提供一种生产低于罗丹明型染料含量和具有不对称烷基的苯甲酮衍生物的方法。 解决方案：生产通式(2)的苯甲酮衍生物的方法包括以下步骤：在有机溶剂存在下，化合物通式(1)与邻苯二甲酸酐反应，将反应产物液体加入水中，以将反应液体调节至pH4.0-7.0，将分离出的有机溶剂层加入水中，以将有机溶剂层调节至pH8.0-14.0，然后将分离出的水层与水溶性有机溶剂混合，沉淀晶体，然后通过过滤分离。在通式(1)和(2)中，R1和R2分别是烷基、环烷基、烷氧基烷基、苯甲基或（取代）苯基，其中R1和R2不相同。 版权所有：(C)2006，JPO&NCIPI
• Process for preparing N-alkylaminophenols and N,N-dialkylaminophenols
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0427572A1

  公开（公告）日：1991-05-15

  To prepare an N-alkylaminophenol an aminophenol is subjected to reductive alkylation with an aliphatic or cyclic aldehyde or ketone in the presence of an organic solvent (e.g. an alcohol), hydrogen, and a reduction catalyst comprising platinum or palladium and at least one metal element selected from the IB, IIB, IVB, VB and VIB group of the Periodic Table, either supported on activated carbon, or which has been contact treated with a solution containing at least one said metal element. The preferred amount of the metal in the catalyst is 0.001 to 0.5 part by weight. The preferred amount of the catalyst is 0.0001 to 0.02 part by weight as Pt or Pd per part of the aminophenol. The catalyst can be recovered and reused. The preparation of the catalyst is described.

  为制备 N-烷基氨基苯酚，氨基苯酚在有机溶剂（如醇）、氢和还原催化剂的存在下，与脂族或环族醛或酮进行还原烷基化反应，还原催化剂由铂或钯和至少一种选自元素周期表 IB、IIB、IVB、VB 和 VIB 族的金属元素组成。 按重量计，催化剂中的金属量最好为 0.001 至 0.5 份。催化剂的优选量为每份氨基苯酚含 0.0001 至 0.02 份重量的铂或钯。 催化剂可以回收和重复使用。 催化剂的制备方法已作说明。
• Process for preparing N-alkyl-substituted aminophenols
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0411817A2

  公开（公告）日：1991-02-06

  A process for preparing an N-alkyl-substituted amino­phenol comprises continuously feeding an aldehyde or a ketone to a reaction system containing an organic solvent, e.g., methanol or ethanol, a catalyst for reduction (e.g., Pt or Pd), hydrogen, and an aminophenol to conduct a reductive alkylation reaction, wherein said reductive alkylation react­ion is carried our while continuously adding an organic carboxylic acid (e.g. a mono or di-carboxylic or hydroxy­carboxylic acid of up to 8 carbon atoms), in amount of 0.05 to 5 wt % of the aminophenol, diluted with said solvent. The aldehyde or ketone can first be added to the system apart from the acid, which is added continuously when hydrogen absorption has begun. The process attains a high yield even when the catalyst is repeatedly reused, and does not cause corrosion of equipment.

  一种制备 N-烷基取代氨基苯酚的工艺包括：向含有有机溶剂（如甲醇或乙醇）、还原催化剂（如铂或钯）、氢和氨基苯酚的反应体系中连续加入醛或酮，以进行还原烷基化反应、其中，在进行还原烷基化反应的同时，不断加入用所述溶剂稀释的有机羧酸（例如，碳原子数不超过 8 的单羧酸或二羧酸或羟基羧酸），其用量为氨基苯酚的 0.05 至 5 wt %。醛或酮可以先与酸分开加入体系中，当开始吸氢时再继续加入。 即使催化剂重复使用，该工艺也能达到很高的产量，而且不会对设备造成腐蚀。
• Method of producing keto acids
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0511019A2

  公开（公告）日：1992-10-28

  A keto acid of the general formula wherein R¹ and R² independently represent alkyl of 1-6 carbons or cycloalkyl of 4-8 carbons is produced by reacting a m-aminophenol of the general formula of wherein R¹ and R² are as hereindefined, with phthalic anhydride, in the presence of a controlled amount of an organic solvent to deposit the resultant keto acid in the solvent while effecting the reaction in a slurry.

  通式为 其中 R¹ 和 R² 分别代表 1-6 个碳原子的烷基或 4-8 个碳原子的环烷基。 其中 R¹ 和 R² 如下定义）的间氨基苯酚与邻苯二甲酸酐反应，在有控制量的有机溶剂存在下，将生成的酮酸沉积在溶剂中，同时在浆液中进行反应。