N-hydroxy-N-(1-benzo[b]thien-2-ylethyl) N'-ethylurea | 118564-77-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: N-hydroxy-N-(1-benzo[b]thien-2-ylethyl) N'-ethylurea
• 英文别名: 1-[1-(1-Benzothiophen-2-YL)ethyl]-3-ethyl-1-hydroxyurea
• CAS: 118564-77-5
• 化学式: C₁₃H₁₆N₂O₂S
• 分子量: 264.348
• InChiKey: QECDFJOPYQTXGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  80.8
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a lipoxygenase inhibitor for treatment of asthma or chronic obstructive pulmonary disease
  申请人：Robinson B. Cynthia

  公开号：US20050090455A1

  公开（公告）日：2005-04-28

  A pharmaceutical or veterinary composition, comprises a first active agent selected from a dehydroepiandrosterone and/or dehydroepiandrosterone-sulfate, or a salt thereof, and a second active agent comprising a lipoxygenase inhibitor for the treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases.

  一种药物或兽药组合物，包括从去氢表雄酮和/或去氢表雄酮硫酸盐中选择的第一活性成分，以及包括一种脂氧合酶抑制剂的第二活性成分，用于治疗哮喘、慢性阻塞性肺病或其他呼吸系统疾病。该组合物以各种配方形式提供，并以套装形式提供。该专利的产品用于预防和治疗哮喘、慢性阻塞性肺病或其他呼吸系统疾病。
• Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
  申请人：ABBOTT LABORATORIES

  公开号：EP0279263B1

  公开（公告）日：1993-08-04
• US4873259A
  申请人：——

  公开号：US4873259A

  公开（公告）日：1989-10-10
• [EN] COMBINATION OF DEHYDROEPIANDROSTERONE OR DEHYDROEPIANDROSTERONE-SULFATE WITH A LIPOXYGENASE IHIBITOR FOR TREATMENT OF ASTHMA OR CHRONIC OBSTRUCTIVE PULMONARY DISEASE<br/>[FR] COMBINAISON DE DESHYDROEPIANDROSTERONE OU DE SULFATE DE DESHYDROEPIANDROSTERONE AVEC UN INHIBITEUR DE LA LIPOXYGENASE POUR LE TRAITEMENT DE L'ASTHME OU DE LA BRONCHOPNEUMOPATHIE OBSTRUCTIVE CHRONIQUE
  申请人：EPIGENESIS PHARMACEUTICALS LLC

  公开号：WO2005011613A2

  公开（公告）日：2005-02-10

  A pharmaceutical or veterinary composition, comprises a first active agent selected from a dehydroepiandrosterone and/or dehydroepiandrosterone-sulfate, or a salt thereof, and a second active agent comprising a lipoxygenase inhibitor for the treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases.