甲氧基-X04 | 863918-78-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 甲氧基-X04
• 中文别名: 甲氧基X04
• 英文名称: methoxy-X04
• 英文别名: 4-[(E)-2-[4-[(E)-2-(4-hydroxyphenyl)ethenyl]-3-methoxyphenyl]ethenyl]phenol
• CAS: 863918-78-9
• 化学式: C₂₃H₂₀O₃
• 分子量: 344.41
• InChiKey: FGYNZFHVGOFCMD-KHVHPYDTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,4-bis(bromomethyl)-2-methoxybenzene 在 四丁基氟化铵 、 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 48.0h， 生成 甲氧基-X04
  参考文献：
  名称：

  Polyfluorinated bis-styrylbenzenes as amyloid-β plaque binding ligands

  摘要：

  Detection of cerebral beta-amyloid (A beta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential A beta imaging agents. To further explore their potency as F-19 MRI contrast agents we synthetized several novel fluorinated bis-styrylbenzenes and studied their fluorescent properties and amyloid-beta binding characteristics. The compounds showed a high affinity for Ab plaques on murine and human brain sections. Interestingly, competitive binding experiments demonstrated that they bound to a different binding site than chrysamine G. Despite their high logP values, many bis-styrylbenzenes were able to enter the brain and label murine amyloid in vivo. Unfortunately initial post-mortem F-19 NMR studies showed that these compounds as yet do not warrant further MRI studies due to the reduction of the 19F signal in the environment of the brain. (C) 2014 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2014.02.054

文献信息

• [EN] MRI IMAGING OF AMYLOID PLAQUE USING LIPOSOMES<br/>[FR] IMAGERIE IRM DE LA PLAQUE AMYLOÏDE AU MOYEN DE LIPOSOMES
  申请人：TEXAS CHILDREN S HOSPTIAL

  公开号：WO2016057812A1

  公开（公告）日：2016-04-14

  Provided are aromatic compounds, phospholipid-polymer-aromatic conjugates comprising the aromatic compounds, and liposome compositions including the phospholipid- polymer-aromatic conjugates. The liposomal compositions may be useful for imaging of Alzheimer's Disease, for example, imaging of the amyloid-β plaque deposits characteristic of Alzheimer's Disease.

  提供了含芳香化合物的磷脂-聚合物-芳香族共轭物，以及包括这些磷脂-聚合物-芳香族共轭物的脂质体组合物。这些脂质体组合物可能用于阿尔茨海默病的成像，例如成像阿尔茨海默病特征性的淀粉样蛋白β斑块沉积物。
• Methods of preparing ophthalmic formulations and uses of same
  申请人：Cognoptix, Inc.

  公开号：US10350309B2

  公开（公告）日：2019-07-16

  The present invention relates to a process for preparing an ointment comprising subjecting a mixture of a fluorescent molecular rotor compound, mineral oil, and grinding media to ball milling agitation and combining this mixture with a hydrophobic vehicle for an ointment. The invention also relates to an ophthalmic formulation comprising a pharmaceutically acceptable carrier and a compound of the following structural Formula (I), or a pharmaceutically acceptable salt thereof: Values and preferred values of the variables in structural Formula (I) are described herein.

  本发明涉及一种制备软膏的工艺，包括将荧光分子转子化合物、矿物油和研磨介质的混合物进行球磨搅拌，并将该混合物与软膏的疏水性载体结合。本发明还涉及一种眼科制剂，该制剂包含一种药学上可接受的载体和一种结构式（I）如下的化合物或其药学上可接受的盐： 结构式（I）中各变量的值和优选值在此描述。
• MRI imaging of amyloid plaque using liposomes
  申请人：Texas Children's Hospital

  公开号：US11141495B2

  公开（公告）日：2021-10-12

  Provided are aromatic compounds, phospholipid-polymer-aromatic conjugates comprising the aromatic compounds, and liposome compositions including the phospholipid-polymer-aromatic conjugates. The liposomal compositions may be useful for imaging of Alzheimer's Disease, for example, imaging of the amyloid-β plaque deposits characteristic of Alzheimer's Disease.

  本文提供了芳香族化合物、包含芳香族化合物的磷脂-聚合物-芳香族共轭物以及包含磷脂-聚合物-芳香族共轭物的脂质体组合物。 脂质体组合物可用于阿尔茨海默病的成像，例如阿尔茨海默病特有的淀粉样β斑块沉积的成像。
• LIPID-BASED NANOPARTICLES
  申请人：Board of Regents of the University of Texas System

  公开号：EP2694116B1

  公开（公告）日：2018-06-13
• METHODS OF PREPARING OPHTHALMIC FORMULATIONS AND USES OF SAME
  申请人：Cognoptix, Inc.

  公开号：EP3062821A1

  公开（公告）日：2016-09-07