cis-(1S,4S)-4-phenyl-1,2,3,4-tetrahydro-1-naphthol | 146075-73-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: cis-(1S,4S)-4-phenyl-1,2,3,4-tetrahydro-1-naphthol
• 英文别名: (1S,4S)-4-phenyl-1,2,3,4-tetrahydronaphthalen-1-ol
• CAS: 146075-73-2
• 化学式: C₁₆H₁₆O
• 分子量: 224.302
• InChiKey: DHEQKGXJWLRXTA-BBRMVZONSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-phenyl-3,4-dihydronaphthalen-1(2H)-one 反应 8.0h， 生成 trans-(1S,4R)-4-phenyl-1,2,3,4-tetrahydro-1-naphthol 、 cis-(1S,4S)-4-phenyl-1,2,3,4-tetrahydro-1-naphthol
  参考文献：
  名称：

  Begue, Jean-Pierre; Cerceau, Claude; Dogbeavou, Anukwadey, Journal of the Chemical Society. Perkin transactions I, 1992, # 22, p. 3141 - 3144

  摘要：

  DOI：

文献信息

• Asymmetric reduction of substituted indanones and tetralones catalyzed by chiral dendrimer and its application to the synthesis of (+)-sertraline
  作者：Guangyin Wang、Changwu Zheng、Gang Zhao

  DOI：10.1016/j.tetasy.2006.07.010

  日期：2006.8

  A recoverable dendrimeric supported prolinol was used as a catalyst in the asymmetric reduction of indanones and tetralones to give separable cis and trans isomers up to 97% ee. This method was also applied in the enantio selective synthesis of the antidepressant drug (+)-sertraline. (c) 2006 Elsevier Ltd. All rights reserved.
• Begue, Jean-Pierre; Cerceau, Claude; Dogbeavou, Anukwadey, Journal of the Chemical Society. Perkin transactions I, 1992, # 22, p. 3141 - 3144
  作者：Begue, Jean-Pierre、Cerceau, Claude、Dogbeavou, Anukwadey、Mathe, Laurence、Sicsic, Sames

  DOI：——

  日期：——