4-Quinazolinamine, 6-(3-aminopropoxy)-N-(3-chlorophenyl)-7-methoxy- | 655247-74-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-Quinazolinamine, 6-(3-aminopropoxy)-N-(3-chlorophenyl)-7-methoxy-
• 英文别名: 6-(3-aminopropoxy)-N-(3-chlorophenyl)-7-methoxyquinazolin-4-amine
• CAS: 655247-74-8
• 化学式: C₁₈H₁₉ClN₄O₂
• 分子量: 358.8
• InChiKey: KNNJJBGOAKBCKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  82.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Medium and method for enriching, purifying or depleting atp binding proteins from a pool of proteins
  申请人：Godl Klaus

  公开号：US20060105445A1

  公开（公告）日：2006-05-18

  The present invention relates to a medium and a method for enriching ATP binding proteins, e.g. proteinkinases, from a pool of proteins, like a proteome. The medium of the present invention comprises specific inhibitors, e.g. at least one of the compounds 4-[4-(4-fluoro-phenyl)-5-pyridine-4-yl-1H-imidazole-2-yl]-benzylamine, 2-[4-(2-Amino-ethoxy)-phenylamino]-6-(2,6-dichloro-phenyl)-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one, 2-[1-(3-aminopropyl)-1H-indole-3-yl)maleinmide, 3-[1-(3-Aminopropyl)-1H-indol-3-yl]-3-(1H-indol 3-yl)-maleinmide, 3-[1-(3-Aminopropyl)-1H-indol-3-yl]4-(1-methyl-1H-indol-3-yl) maleinimide, 3-(8-Aminomethyl-6,7,8,9-tetrahydropyrido-[1,2-a]-indol-10-yl) (1-methyl-1H-indol -3-yl)-maleinmide, [6-(3-Amino-propoxy)-methoxy-quinazolin-4-yl]-(3-chloro-phenyl)-amine, 6-(3-Amino-propoxy)-7-methoxy-quinazolin-4-yl-(3-chloro-4-fluoro-phenyl)-amine, 6-(3Amino-propoxy)-7-methoxy-quinazolin-4-yl]-(3-bromo-phenyl)-amine and 4-[4-(4-Amino-butyl)-piperazin-1-yl-methyl]-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide immobilized on a support material. According to the method of the present invention the above-mentioned immobilized compounds are used to selectively bind protein kinases from a pool of heterogeneous proteins.

  本发明涉及一种从蛋白质池（如蛋白质组）中富集ATP结合蛋白质（如蛋白激酶）的介质和方法。本发明的介质包括特定的抑制剂，例如以下至少一种化合物：4-[4-(4-氟苯基)-5-吡啶基-4-基]-1H-咪唑-2-基]苯甲胺，2-[4-(2-氨基乙氧基)-苯基氨基]-6-(2,6-二氯苯基)-8-甲基-8H-吡啶[2,3-d]嘧啶-7-酮，2-[1-(3-氨丙基)-1H-吲哚-3-基]马来酰亚胺，3-[1-(3-氨丙基)-1H-吲哚-3-基]-3-(1H-吲哚-3-基)-马来酰亚胺，3-[1-(3-氨丙基)-1H-吲哚-3-基]4-(1-甲基-1H-吲哚-3-基)马来酰亚胺，3-(8-氨甲基-6,7,8,9-四氢吡啶[1,2-a]-吲哚-10-基)(1-甲基-1H-吲哚-3-基)-马来酰亚胺，[6-(3-氨基丙氧基)-甲氧基喹唑啉-4-基]-(3-氯苯基)-胺，6-(3-氨基丙氧基)-7-甲氧基喹唑啉-4-基-(3-氯-4-氟苯基)-胺，6-(3-氨基丙氧基)-7-甲氧基喹唑啉-4-基]-(3-溴苯基)-胺和4-[4-(4-氨基丁基)-哌嗪-1-基甲基]-N-[4-甲基-3-(4-吡啶-3-基-嘧啶-2-基氨基)-苯基]-苯甲酰胺，这些化合物被固定在支持材料上。根据本发明的方法，上述固定化化合物被用于从杂多蛋白质池中选择性地结合蛋白激酶。
• METHOD FOR ISOLATING ATP BINDING PROTEINS BY MEANS OF IMMOBILIZED PROTEIN INHIBITORS
  申请人：Axxima Pharmaceuticals AG

  公开号：EP1527345A2

  公开（公告）日：2005-05-04
• [EN] MEDIUM AND METHOD FOR ENRICHING, PURIFYING OR DEPLETING ATP BINDING PROTEINS FROM A POOL OF PROTEINS<br/>[FR] MILIEU ET METHODE D'ENRICHISSEMENT, DE PURIFICATION OU D'APPAUVRISSEMENT DE PROTEINES DE LIAISON A L'ATP A PARTIR D'UN RESERVOIR DE PROTEINES
  申请人：AXXIMA PHARMACEUTICALS AG

  公开号：WO2004013633A2

  公开（公告）日：2004-02-12

  The present invention relates to a medium and a method for enriching ATP binding proteins, e.g. proteinkinases, from a pool of proteins, like a proteome. The medium of the present invention comprises specific inhibitors, e.g. at least one of the compounds 4-[4-(4-fluoro­-phenyl)-5-pyridine-4-yl-lH-imidazole-2-yl]-benzylamine, 2-[4-(2-Amino-ethoxy)­- phenylamino]-6-(2,6-dichloro-phenyl)-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one, 2-[1-(3­-aminopropyl)-1H-indole-3-yl)maleimide, 3-[1-(3-Aminopropyl)-1H-indol-3-yl]-3-(1H-indol­ 3-yl)-maleinmide, 3-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-lH-indol-3-yl) maleinimide, 3-(8-Aminomethyl-6,7,8,9-tetrahydropyrido-[1,2-a]-indol-10-yl)-4-(1-methyl-lH-indol -3-y1)-maleinmide, [6-(3-Amino-propoxy)-methoxy-quinazolin-4-yl]-(3-chloro-phenyl)-amine, 6-(3-Amino-propoxy)-7-methoxy-quinazolin-4-yl-(3-chloro-4-fluoro-phenyl)-amine, 6-(3­Amino-propoxy)-7-methoxy-quinazolin-4-yl]-(3-bromo-phenyl)-amine and 4-[4-(4-Amino-butyl)-piperazin-l-yl-methyl]-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide immobilized on a support material. According to the method of the present invention the above-mentioned immobilized compounds are used to selectively bind protein kinases (e.g. p38, JNK1, JNK2, CK18, RICK, GAK) from a pool of heterogeneous proteins.