[1-[(2-aminopyrimidin-5-yl)methyl]piperidin-4-yl]-[4-[(E)-N-methoxy-C-pyridin-2-ylcarbonimidoyl]piperidin-1-yl]methanone | 416850-68-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: [1-[(2-aminopyrimidin-5-yl)methyl]piperidin-4-yl]-[4-[(E)-N-methoxy-C-pyridin-2-ylcarbonimidoyl]piperidin-1-yl]methanone
• CAS: 416850-68-5
• 化学式: C₂₃H₃₁N₇O₂
• 分子量: 437.545
• InChiKey: NKSXGQXVMGRMKG-SGWCAAJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-氨基-5-嘧啶甲醛 在 溶剂黄146 N-乙基吗啉 、 lithium hydroxide 、 水 、 1-丙基磷酸酐 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 39.17h， 生成 [1-[(2-aminopyrimidin-5-yl)methyl]piperidin-4-yl]-[4-[(E)-N-methoxy-C-pyridin-2-ylcarbonimidoyl]piperidin-1-yl]methanone
  参考文献：
  名称：

  WO2008/108957

  摘要：

  公开号：

文献信息

• Synthesis of 4-(piperidyl)(2-pyridyl)methanone-(E)-O-methyloxime and salts
  申请人：SCHERING CORPORATION

  公开号：US20030105136A1

  公开（公告）日：2003-06-05

  In one embodiment, the present invention describes the synthesis of 4-(piperidyl) (2-pyridyl)methanone-(E)-O-methyloxime dihydrochloride, monohydrochloride and free base, and similar compounds, in high stereochemical purity.

  在一个实施方案中，本发明描述了高立体化学纯度的 4-(哌啶基) (2-吡啶基)甲酮-(E)-O-甲基肟二盐酸盐、单盐酸盐和游离碱以及类似化合物的合成。
• SYNTHESIS OF 4-(PIPERIDYL) (2-PYRIDYL)METHANONE-(E)-O-METHYLOXIME AND ITS SALTS
  申请人：SCHERING CORPORATION

  公开号：EP1436282A1

  公开（公告）日：2004-07-14
• Combination of an H3 antagonist/inverse agonist and an appetite suppressant
  申请人：van Heek Margaret

  公开号：US20070142369A1

  公开（公告）日：2007-06-21

  The present invention relates to pharmaceutical compositions comprising therapeutic combinations comprising: one or more H 3 antagonists/inverse agonists; one or more appetite suppressants selected from the group consisting of CB 1 antagonists/inverse agonists, sibutramine, phentermine and topiramate; and optionally one or more HMG-CoA reductase inhibitors. The invention also relates to medicaments and kits comprising the pharmaceutical compositions of the present invention, and methods of treating obesity, obesity related disorders and diabetes using the pharmaceutical compositions of the present invention.
• NOVEL NON-IMIDAZOLE COMPOUNDS
  申请人：Aslanian Robert G.

  公开号：US20080119487A1

  公开（公告）日：2008-05-22

  Disclosed are novel compounds of the formula Also disclosed are pharmaceutical compositions comprising the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I. Also disclosed are methods of treating various diseases or conditions, such as, for example, allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of Formula I in combination with a H 1 receptor antagonist.
• PIPERIDINYL-PIPERIDINE AND PIPERAZINYL-PIPERIDINE FOR USE IN THE TREATMENT OF DIABETES OR PAIN
  申请人：Aslanian Robert G.

  公开号：US20100093692A1

  公开（公告）日：2010-04-15

  The present invention relates to Compounds of Formula (I), compositions comprising the compounds, and methods of using the compounds to treat or prevent pain, diabetes, a diabetic complication, impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) in a patient.