testosterone pelargonate | 57525-67-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: testosterone pelargonate
• 英文别名: [(8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] nonanoate
• CAS: 57525-67-4
• 化学式: C₂₈H₄₄O₃
• 分子量: 428.656
• InChiKey: TZZDYDXNNUTGHU-FEZCWRLCSA-N

物化性质

• 熔点：
  101.4-102.8 °C
• 沸点：
  527.6±50.0 °C(Predicted)
• 密度：
  1.05±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• STEROID HORMONE DELIVERY SYSTEMS AND METHODS OF PREPARING THE SAME
  申请人：MonoSol Rx, LLC

  公开号：EP2744482A1

  公开（公告）日：2014-06-25
• US20140255473A1
  申请人：——

  公开号：US20140255473A1

  公开（公告）日：2014-09-11
• [EN] STEROID HORMONE DELIVERY SYSTEMS AND METHODS OF PREPARING THE SAME<br/>[FR] SYSTÈMES D'ADMINISTRATION D'HORMONE STÉROÏDE ET PROCÉDÉS DE PRÉPARATION DE CEUX-CI
  申请人：MONOSOL RX LLC

  公开号：WO2013026002A1

  公开（公告）日：2013-02-21

  The present invention is directed to steroid hormone delivery systems and methods of preparing the same. In particular, the steroid hormone delivery systems provided include a primary construct having one or more hydrophobic steroid hormone esters in the form of a liposome, a lipid particle, a micelle, an emulsion or a niosome which is then formulated into a secondary construct for administration. Exemplary secondary constructs include a film for sublingual or buccal administration.
• [EN] STEROID HORMONE DELIVERY SYSTEMS AND METHODS OF PREPARING THE SAME<br/>[FR] SYSTÈMES D'ADMINISTRATION D'HORMONES STÉROÏDES ET PROCÉDÉS DE PRÉPARATION DE CEUX-CI
  申请人：MONOSOL RX LLC

  公开号：WO2014144366A1

  公开（公告）日：2014-09-18

  The present invention is directed to film dosage compositions for delivery of testosterone esters. In particular, a film dosage composition is provided that includes: a) a polymeric matrix and b) a plurality of particles including: i) a testosterone ester and ii) a surfactant. A film dosage composition is also provided that includes: a) a first region including: i) a first polymeric matrix and ii) a first plurality of particles including: 1) a first testosterone ester and 2) a first surfactant; and b) a second region including: i) a second polymeric matrix and ii) a second plurality of particles including: 1) a second testosterone ester and 2) a second surfactant.