(S)-N-[2-(Benzo[b]thiophen-5ylmethanesulfonyl)-1-(4-carboxyphenyl)ethyl]-N-hydroxyformamide | 376387-38-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: (S)-N-[2-(Benzo[b]thiophen-5ylmethanesulfonyl)-1-(4-carboxyphenyl)ethyl]-N-hydroxyformamide
• 英文别名: 4-[(1S)-2-(1-benzothiophen-5-ylmethylsulfonyl)-1-[formyl(hydroxy)amino]ethyl]benzoic acid
• CAS: 376387-38-1
• 化学式: C₁₉H₁₇NO₆S₂
• 分子量: 419.479
• InChiKey: UIICVPHNZXGQJX-QGZVFWFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  149
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (S)-N-[2-(Benzo[b]thiophen-5-ylmethanesulfonyl)-1-(4-ethoxycarbonylphenyl)ethyl]-N-hydroxyformamide 、 disodium;sulfide 生成 (S)-N-[2-(Benzo[b]thiophen-5ylmethanesulfonyl)-1-(4-carboxyphenyl)ethyl]-N-hydroxyformamide
  参考文献：
  名称：

  Bicyclyl or heterobicyclylmethanesulfonylamino-substituted n-hydroxyformamides

  摘要：

  式(I)的化合物：其中1R是氢、烷基、烯基、炔基、芳基、杂芳基或杂环基；而R1是双环或杂双环基，对于治疗和预防由s-CD23介导的疾病是有用的。

  公开号：

  US20040024066A1

文献信息

• Bicyclyl or heterobicyclylmethanesulfonylanimo-substituted N-hydroxyformamides
  申请人：Best John Desmond

  公开号：US20050288376A1

  公开（公告）日：2005-12-29

  Compounds of formula (I): R is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl or heterocyclyl; and R 1 is bicyclyl or heterobicyclyl, are useful in the treatment and prophylaxis of conditions mediated by s-CD23.

  式(I)的化合物： 其中R为氢、烷基、烯基、炔基、芳基、杂芳基或杂环基； R1为双环或杂双环基， 可用于治疗和预防由s-CD23介导的疾病。
• BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP1289980A1

  公开（公告）日：2003-03-12
• [EN] BICYCLYL OR HETEROBICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED N-HYDROXYFORMAMIDES<br/>[FR] N-HYDROXYFORMAMIDES A SUBSTITUTION BICYCLYLE OU HETEROBICYCLYLMETHANESULFONYLAMINO
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2001090100A1

  公开（公告）日：2001-11-29

  Compounds of formula (I): R is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl or heterocyclyl; and R1 is bicyclyl or heterobicyclyl, are useful in the treatment and prophylaxis of conditions mediated by s-CD23.
• Bicyclyl or heterobicyclylmethanesulfonylamino-substituted n-hydroxyformamides
  申请人：——

  公开号：US20040024066A1

  公开（公告）日：2004-02-05

  Compounds of formula (I): 1 R is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl or heterocyclyl; and R 1 is bicyclyl or heterobicyclyl, are useful in the treatment and prophylaxis of conditions mediated by s-CD23.

  式(I)的化合物：1R是氢，烷基，烯基，炔基，芳基，杂芳基或杂环烷基；和R1是双环烷基或杂双环烷基，对由s-CD23介导的疾病的治疗和预防具有用处。