3,3-Dimethyl-1,4-dioxane-2,5-dione | 57321-97-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 3,3-Dimethyl-1,4-dioxane-2,5-dione
• CAS: 57321-97-8
• 化学式: C₆H₈O₄
• 分子量: 144.12
• InChiKey: LLZIQIHXYWEQCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  、 间氯过氧苯甲酸 在 乙酸乙酯 作用下， 以 二氯甲烷 为溶剂， 反应 40.0h， 以3.9 g of analytically pure, 3,3-dimethyl-2,5-dioxane-1,4-dione are thus obtained的产率得到3,3-Dimethyl-1,4-dioxane-2,5-dione
  参考文献：
  名称：

  Method for synthesis of 2,5-dioxane-1,4-diones

  摘要：

  本发明涉及一种合成2,5-二氧杂环戊二酮（式I）的新方法，包括氧化具有式II的环状化合物的酮基，其中R1、R2、R3和R4分别独立地表示氢原子、卤素、（C2-C6）烯基、（C3-C7）环烷基、环己烯基和具有式—（CH2）m—V—W的基团。

  公开号：

  US07504524B2

文献信息

• Method for Synthesis of 2,5-Dioxane-1,4-Diones
  申请人：Bourissou Didier

  公开号：US20080004453A1

  公开（公告）日：2008-01-03

  The invention relates to a novel method for the synthesis of 2,5-dioxane-1,4-diones having formula (I), comprising the oxidation of the ketone function of a cyclic compound having formula (II), wherein R 1 , R 2 , R 3 and R 4 independently represent the hydrogen atom, halo, (C 2 -C 6 ) alkenyl, (C 3 -C 7 )cycloalkyl, cyclohexenyl and a radical having formula —(CH 2 ) m —V—W.

  本发明涉及一种合成2,5-二氧杂环戊二酮（式（I））的新方法，包括氧化具有式（II）的环状化合物的酮基，其中R1、R2、R3和R4独立地表示氢原子、卤素、（C2-C6）烯基、（C3-C7）环烷基、环己烯基和具有式-（CH2）m-V-W的基团。
• [EN] COVALENT MODIFICATION AND CONTROLLED DELIVERY OF MU OPIOID RECEPTOR ANTAGONISTS<br/>[FR] MODIFICATION COVALENTE ET ADMINISTRATION CONTRÔLÉE D'ANTAGONISTES DES RÉCEPTEURS OPIOÏDES DE TYPE MU
  申请人：ALLEGHENY SINGER RES INSTITUTE

  公开号：WO2020205537A1

  公开（公告）日：2020-10-08

  Polymer conjugates comprising a hydrophobic biodegradable polymer covalently attached to a mu opioid receptor (MOR) antagonist are described. Biodegradable covalent nanoparticles comprising the hydrophobic biodegradable polymer covalently attached to a MOR antagonist are provided as a vehicle for the sustained delivery of the MOR antagonist. The described MOR antagonist delivery system may be used to more effectively prevent or overcome the toxic effects of synthetic opioids.

  本文描述了由疏水生物可降解聚合物共价连接至μ-阿片受体（MOR）拮抗剂的聚合物共轭物。提供了由疏水生物可降解聚合物共价连接至MOR拮抗剂的生物可降解共价纳米粒子，作为MOR拮抗剂持续释放的载体。所述的MOR拮抗剂释放系统可用于更有效地预防或克服合成阿片类药物的毒性作用。
• Surgical sutures of unsymmetrically substituted 1,4-dioxane-2,5-diones
  申请人：American Cyanamid Company

  公开号：US03960152A1

  公开（公告）日：1976-06-01

  Unsymmetrically 3,6-substituted 1,4-dioxane-2,5-diones may be polymerized to give living-tissue absorbable, hydrolytically degradable surgically useful polymers. These polymers have predominantly regular rather than random spacings of side chains, may be stereoregular and tend toward higher crystallinity than randomly sequenced polymers. A polymer of 3-methyl-1,4-dioxane-2,5-dione has the same empirical formula as an equimolecular copolymer of lactic and glycolic acid but has unique physical properties resulting from its more regular steric configuration. Polymers and copolymers of 3- and 3,6-unsymmetrically substituted 1,4-dioxane-2,5-diones have surgically useful mechanical properties. On implantation, in living mammalian tissue, the polymers are absorbed, and replaced by living tissue.

  不对称的3,6-取代的1,4-二噁烷-2,5-二酮可以聚合成可吸收活体组织、水解降解的手术有用聚合物。这些聚合物具有主要是侧链间隔规则而不是随机的特点，可能是立体规则的，倾向于比随机序列的聚合物具有更高的结晶度。3-甲基-1,4-二噁烷-2,5-二酮的聚合物与乳酸和甘醇酸的等分子共聚物具有相同的经验式，但由于其更规则的立体构型而具有独特的物理特性。3-和3,6-不对称取代的1,4-二噁烷-2,5-二酮的聚合物和共聚物具有手术有用的机械性能。在植入到活体哺乳动物组织中后，这些聚合物会被吸收并被活体组织所取代。
• Polymers of unsymmetrically substituted 1,4-dioxane-2,5-diones
  申请人：American Cyanamid Company

  公开号：US04033938A1

  公开（公告）日：1977-07-05

  Unsymmetrically 3,6-substituted 1,4-dioxane-2,5-diones may be polymerized to give living-tissue absorbable, hydrolytically degradable surgically useful polymers. These polymers have predominantly regular rather than random spacings of side chains, may be stereoregular and tend toward higher crystallinity than randomly sequenced polymers. A polymer of 3-methyl-1,4-dioxane-2,5-dione has the same empirical formula as an equimolecular copolymer of lactic and glycolic acid but has unique physical properties resulting from its more regular steric configuration. Polymers and copolymers of 3- and 3,6-unsymmetrically substituted 1,4-dioxane-2,5-diones have surgically useful mechanical properties. On implantation, in living mammalian tissue, the polymers are absorbed, and replaced by living tissue.

  非对称的3,6-取代1,4-二噁烷-2,5-二酮可以聚合成可被生物吸收、水解降解的手术用聚合物。这些聚合物具有主要是侧链具有规则而不是随机间距的特点，可能是立体规则的，且倾向于比随机序列聚合物具有更高的结晶度。3-甲基-1,4-二噁烷-2,5-二酮的聚合物与乳酸和甘醇酸的等分子共聚物具有相同的经验式，但由于其更规则的空间构型而具有独特的物理特性。3-和3,6-非对称取代的1,4-二噁烷-2,5-二酮的聚合物和共聚物具有手术上有用的机械性能。在植入到活体哺乳动物组织中后，聚合物会被吸收并被活体组织所取代。
• METHODS FOR PRODUCING LACTIDE WITH RECYCLE OF MESO-LACTIDE
  申请人：Benson Richard Douglas

  公开号：US20110306749A1

  公开（公告）日：2011-12-15

  An S, S- and R,R-lactide stream suitable for polymerization is prepared by producing a low molecular weight poly(lactic acid), depolymerizing the low molecular weight poly(lactic acid) to form a mixture of S, S-, R,R- and meso-lactide, and separating meso-lactide from this mixture to form an S, S- and R,R-lactide stream. Meso-lactide is recycled into the process, and shifts the mole fractions of the lactides in the lactide mixture that is produced.

  一种适用于聚合的S，S-和R，R-乳酸酯流的制备方法，包括制备低分子量聚乳酸，将低分子量聚乳酸解聚以形成S，S-，R，R-和meso-乳酸酯的混合物，并从该混合物中分离出meso-乳酸酯以形成S，S-和R，R-乳酸酯流。将meso-乳酸酯回收到过程中，并改变所产生的乳酸酯混合物中的乳酸酯摩尔分数。